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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ginkgolide A
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Accession:CHEBI:5355 term browser browse the term
Definition:A diterpene lactone that has formula C20H24O9.
Synonyms:related_synonym: Formula=C20H24O9;   InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17?,18?,19-,20-/m1/s1;   InChIKey=FPUXKXIZEIDQKW-TVPHMGRTSA-N;   SMILES=C[C@@H]1C(=O)O[C@H]2CC34[C@H]5C[C@@H](C(C)(C)C)C33C(O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
 xref: CAS:15291-75-5;   KEGG:C07601;   KNApSAcK:C00003429
 xref_mesh: MESH:C477042


show annotations for term's descendants           Sort by:
Ginkgolide A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO ginkgolide A results in increased expression of ABCB1 mRNA CTD PMID:19034627 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ginkgolide A results in increased expression of ABCC2 mRNA CTD PMID:19034627 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:31697926 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Alb albumin multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:31697926 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of CALCA protein] CTD PMID:31697926 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression		 EXP ginkgolide A results in increased activity of CYP1A2 protein
ginkgolide A results in increased expression of CYP1A2 mRNA		 CTD PMID:18421621 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO ginkgolide A results in increased expression of CYP2B6 mRNA CTD PMID:19034627 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP ginkgolide A results in increased expression of CYP3A18 mRNA CTD PMID:16258077 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP
ISO		 ginkgolide A results in increased expression of CYP3A2 mRNA
ginkgolide A results in increased expression of CYP3A4 mRNA		 CTD PMID:16258077 PMID:19034627 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity
increases expression		 EXP ginkgolide A results in increased activity of CYP3A23-3A1 protein
ginkgolide A results in increased expression of CYP3A23-3A1 mRNA		 CTD PMID:16258077 PMID:17045319 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:31697926 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ginkgolide A affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] CTD PMID:31697926 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] CTD PMID:31697926 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of LBP protein] CTD PMID:31697926 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein] CTD PMID:31697926 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO ginkgolide A results in increased activity of NR1I2 protein
ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NR1I2 protein]		 CTD PMID:19034627 PMID:31697926 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ocln occludin multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of OCLN protein] CTD PMID:31697926 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:31697926 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of TJP1 protein] CTD PMID:31697926 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein] CTD PMID:31697926 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:31697926 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ginkgolide A results in increased expression of UGT1A1 mRNA CTD PMID:19034627 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19893
    chemical entity 19891
      atom 19891
        nonmetal atom 19814
          carbon atom 19767
            organic molecular entity 19767
              isoprenoid 14081
                terpenoid 13781
                  diterpenoid 13045
                    diterpene lactone 259
                      Ginkgolide A 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19893
    subatomic particle 19891
      composite particle 19891
        hadron 19891
          baryon 19891
            nucleon 19891
              atomic nucleus 19891
                atom 19891
                  main group element atom 19830
                    p-block element atom 19830
                      carbon group element atom 19771
                        carbon atom 19767
                          organic molecular entity 19767
                            heteroorganic entity 19525
                              organochalcogen compound 19286
                                organooxygen compound 19202
                                  ester 17478
                                    carboxylic ester 16771
                                      lactone 13314
                                        terpene lactone 2189
                                          diterpene lactone 259
                                            Ginkgolide A 23
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