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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Calpeptin
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Accession:CHEBI:3330 term browser browse the term
Definition:An amino acid amide that has formula C20H30N2O4.
Synonyms:related_synonym: Formula=C20H30N2O4;   InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1;   InChIKey=PGGUOGKHUUUWAF-ROUUACIJSA-N;   N-Cbz-leu-nleu-al;   SMILES=CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
 xref: CAS:117591-20-5;   KEGG:C11256;   LINCS:LSM-2570
 xref_mesh: MESH:C071482



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Calpeptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases cleavage
ISO calpeptin inhibits the reaction [Arsenic Trioxide results in increased cleavage of BAX protein]; calpeptin inhibits the reaction [sodium arsenite results in increased cleavage of BAX protein]
calpeptin results in decreased cleavage of BAX protein
CTD PMID:15131059 PMID:34861471 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Capn1 calpain 1 multiple interactions ISO
EXP
calpeptin inhibits the reaction [CAPN1 protein results in increased degradation of MFN2 protein]; calpeptin inhibits the reaction [Paraquat results in increased activity of CAPN1 protein]
calpeptin inhibits the reaction [Acrylamide results in increased expression of CAPN1 protein]
CTD PMID:24509835 PMID:25416777 PMID:30096436 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of CAPN2 protein] CTD PMID:29524570 PMID:30096436 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
calpeptin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
calpeptin inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; calpeptin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]
CTD PMID:21683092 PMID:25947082 PMID:29111403 PMID:35525317 PMID:36640868 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO calpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO calpeptin results in decreased expression of CCNE2 protein CTD PMID:22432027 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of CDK5 protein] CTD PMID:30096436 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO calpeptin inhibits the reaction [arsenite metabolite results in increased cleavage of CDK5R1 protein]; calpeptin inhibits the reaction [Calcium results in increased cleavage of CDK5R1 protein] CTD PMID:18242949 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO calpeptin results in increased expression of CDKN1A protein CTD PMID:22432027 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO calpeptin results in decreased expression of CDKN1B protein modified form CTD PMID:22432027 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO calpeptin affects the reaction [Acetaminophen affects the phosphorylation of DNM1L protein]; calpeptin inhibits the reaction [Acetaminophen results in increased expression of and results in increased cleavage of DNM1L protein] CTD PMID:35713544 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO calpeptin inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:35713544 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsdme gasdermin E multiple interactions ISO calpeptin inhibits the reaction [Cisplatin results in increased cleavage of GSDME protein] CTD PMID:35525317 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO calpeptin inhibits the reaction [dehydroeburicoic acid affects the localization of MAP1LC3B protein]; calpeptin inhibits the reaction [dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine]] CTD PMID:19848398 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in decreased expression of MAP2 protein]; calpeptin inhibits the reaction [Acrylamide results in increased expression of MAP2 protein] CTD PMID:29524570 PMID:30096436 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of MAPT protein] CTD PMID:30096436 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO
EXP
calpeptin inhibits the reaction [Acetaminophen results in decreased expression of and results in increased cleavage of MFN2 protein]; calpeptin inhibits the reaction [CAPN1 protein results in increased degradation of MFN2 protein]
calpeptin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein]
CTD PMID:25416777 PMID:35713544 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP calpeptin inhibits the reaction [Calcium results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
calpeptin inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein]
calpeptin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:25947082 PMID:29111403 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 decreases phosphorylation
multiple interactions
ISO calpeptin results in decreased phosphorylation of PTPN11 protein
LM11A-31 inhibits the reaction [calpeptin results in decreased phosphorylation of PTPN11 protein]
CTD PMID:25277379 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rhoa ras homolog family member A increases activity
multiple interactions
ISO calpeptin results in increased activity of RHOA protein
LM11A-31 inhibits the reaction [calpeptin results in increased activity of RHOA protein]
CTD PMID:25277379 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Snca synuclein alpha multiple interactions ISO calpeptin inhibits the reaction [Paraquat results in increased expression of SNCA protein alternative form] CTD PMID:24509835 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions ISO calpeptin inhibits the reaction [dehydroeburicoic acid results in increased degradation of SPTAN1 protein]
calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]
CTD PMID:19848398 PMID:21683092 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO calpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form] CTD PMID:21516125 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of TUBB protein]; calpeptin inhibits the reaction [Acrylamide results in increased expression of TUBB5 protein] CTD PMID:29524570 PMID:30096436 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases degradation ISO calpeptin results in decreased degradation of XIAP protein CTD PMID:16223472 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      atom 19839
        nonmetal atom 19777
          nitrogen atom 18962
            nitrogen molecular entity 18962
              organonitrogen compound 18812
                carboxamide 17548
                  amino acid amide 1459
                    Calpeptin 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              amino acid amide 1459
                                                Calpeptin 26
paths to the root