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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,4-dichlorophenol
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Accession:CHEBI:16738 term browser browse the term
Definition:A dichlorophenol that is phenol carrying chloro substituents at positions 2 and 4.
Synonyms:related_synonym: Formula=C6H4Cl2O;   InChI=1S/C6H4Cl2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H;   InChIKey=HFZWRUODUSTPEG-UHFFFAOYSA-N;   SMILES=Oc1ccc(Cl)cc1Cl
 alt_id: CHEBI:11440;   CHEBI:19350;   CHEBI:909
 xref: CAS:120-83-2;   Gmelin:261170;   HMDB:HMDB0004811;   KEGG:C02625
 xref_mesh: MESH:C004762
 xref: MetaCyc:24-DICHLOROPHENOL;   PMID:10633543;   Reaxys:742467;   UM-BBD_compID:c0289;   Wikipedia:2\,4-Dichlorophenol


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2,4-dichlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO 2,4-dichlorophenol affects the activity of AHR protein CTD PMID:18294747 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor affects activity
multiple interactions		 ISO 2,4-dichlorophenol affects the activity of AR protein
2,4-dichlorophenol inhibits the reaction [Androgens binds to AR protein]; 2,4-dichlorophenol promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein]		 CTD PMID:16107550 PMID:18294747 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgef37 Rho guanine nucleotide exchange factor 37 increases methylation ISO 2,4-dichlorophenol results in increased methylation of ARHGEF37 gene CTD PMID:34523531 NCBI chr18:54,935,256...55,001,017
Ensembl chr18:54,949,110...55,000,669 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO 2,4-dichlorophenol results in increased expression of ATF6 mRNA; 2,4-dichlorophenol results in increased expression of ATF6 protein CTD PMID:25160872 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Casp3 caspase 3 increases activity ISO 2,4-dichlorophenol results in increased activity of CASP3 protein CTD PMID:25160872 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity ISO 2,4-dichlorophenol results in decreased activity of CAT protein CTD PMID:11023648 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Crh corticotropin releasing hormone decreases secretion ISO 2,4-dichlorophenol results in decreased secretion of CRH protein CTD PMID:30940137 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 affects binding ISO 2,4-dichlorophenol binds to CYP11A1 protein CTD PMID:32278787 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects binding ISO 2,4-dichlorophenol binds to CYP1B1 protein CTD PMID:32278787 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of DDIT3 mRNA]
2,4-dichlorophenol results in increased expression of DDIT3 mRNA; 2,4-dichlorophenol results in increased expression of DDIT3 protein		 CTD PMID:25160872 PMID:27853103 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
increases expression		 ISO 2,4-dichlorophenol results in increased phosphorylation of EIF2S1 protein
Enzyme Inhibitors promotes the reaction [2,4-dichlorophenol results in increased expression of EIF2S1 protein modified form]		 CTD PMID:25160872 PMID:27853103 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO 2,4-dichlorophenol results in increased expression of ERN1 mRNA CTD PMID:25160872 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO 2,4-dichlorophenol binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gng11 G protein subunit gamma 11 increases methylation ISO 2,4-dichlorophenol results in increased methylation of GNG11 gene CTD PMID:34523531 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO 2,4-dichlorophenol results in increased expression of HSPA5 mRNA; 2,4-dichlorophenol results in increased expression of HSPA5 protein
ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 protein]		 CTD PMID:25160872 PMID:27853103 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Irf7 interferon regulatory factor 7 increases methylation ISO 2,4-dichlorophenol results in increased methylation of IRF7 gene CTD PMID:34523531 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions EXP 2,4-dichlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein] CTD PMID:16617682 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO 2,4-dichlorophenol results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Serpine1 serpin family E member 1 affects binding ISO 2,4-dichlorophenol binds to SERPINE1 protein CTD PMID:32278787 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO 2,4-dichlorophenol results in increased splicing of XBP1 mRNA CTD PMID:25160872 PMID:27853103 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
prothiofos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [prothiophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO prothiophos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO prothiophos results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [prothiophos results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO prothiophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO prothiophos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO prothiophos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      molecular entity 19896
        polyatomic entity 19848
          heteroatomic molecular entity 19806
            halide 18685
              organohalogen compound 18549
                halophenol 2537
                  chlorophenol 1215
                    dichlorophenol 27
                      2,4-dichlorophenol 25
                        prothiofos 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                carbocyclic compound 18601
                                  benzenoid aromatic compound 18028
                                    benzenes 17893
                                      chlorobenzenes 15061
                                        chlorophenol 1215
                                          dichlorophenol 27
                                            2,4-dichlorophenol 25
                                              prothiofos 7
paths to the root