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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prothiofos
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Accession:CHEBI:38873 term browser browse the term
Definition:An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid.
Synonyms:exact_synonym: O-(2,4-dichlorophenyl) O-ethyl S-propyl phosphorodithionate
 related_synonym: Dichlorpropaphos;   Formula=C11H15Cl2O2PS2;   InChI=1S/C11H15Cl2O2PS2/c1-3-7-18-16(17,14-4-2)15-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3;   InChIKey=FITIWKDOCAUBQD-UHFFFAOYSA-N;   O-(2,4-dichlorophenyl) O-ethyl S-propyl dithiophosphate;   Prothiophos;   SMILES=CCCSP(=S)(OCC)Oc1ccc(Cl)cc1Cl
 xref: Beilstein:1998314;   CAS:34643-46-4;   KEGG:C18405
 xref_mesh: MESH:C032072
 xref: PMID:10384797;   PMID:11337831;   PMID:11347620;   PMID:12842175;   PMID:17287007;   PMID:17592615;   PMID:19737786;   PMID:20390940;   PMID:21744237;   PMID:3192132;   PPDB:560;   Reaxys:1998314


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prothiofos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [prothiophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO prothiophos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO prothiophos results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [prothiophos results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO prothiophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO prothiophos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO prothiophos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        agrochemical 16289
          prothiofos 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      chalcogen 19534
                        oxygen atom 19509
                          oxygen molecular entity 19509
                            hydroxides 19320
                              oxoacid 18744
                                pnictogen oxoacid 13224
                                  phosphorus oxoacid 12429
                                    phosphoric acids 11430
                                      phosphoric acid 11430
                                        phosphoric acid derivative 11239
                                          phosphate 11238
                                            organic phosphate 11238
                                              organic thiophosphate 8622
                                                prothiofos 7
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