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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dichlorophenol
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Accession:CHEBI:23702 term browser browse the term
Definition:Any chlorophenol carrying chloro substituents.
Synonyms:xref: Wikipedia:Dichlorophenol

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2,4-dichlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO 2,4-dichlorophenol affects the activity of AHR protein CTD PMID:18294747 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ar androgen receptor affects activity
multiple interactions		 ISO 2,4-dichlorophenol affects the activity of AR protein
2,4-dichlorophenol inhibits the reaction [Androgens binds to AR protein]; 2,4-dichlorophenol promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein]		 CTD PMID:16107550 PMID:18294747 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO 2,4-dichlorophenol results in increased expression of ATF6 mRNA; 2,4-dichlorophenol results in increased expression of ATF6 protein CTD PMID:25160872 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Casp3 caspase 3 increases activity ISO 2,4-dichlorophenol results in increased activity of CASP3 protein CTD PMID:25160872 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase decreases activity ISO 2,4-dichlorophenol results in decreased activity of CAT protein CTD PMID:11023648 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 affects binding ISO 2,4-dichlorophenol binds to CYP11A1 protein CTD PMID:32278787 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects binding ISO 2,4-dichlorophenol binds to CYP1B1 protein CTD PMID:32278787 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of DDIT3 mRNA]
2,4-dichlorophenol results in increased expression of DDIT3 mRNA; 2,4-dichlorophenol results in increased expression of DDIT3 protein		 CTD PMID:25160872 PMID:27853103 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
increases expression		 ISO 2,4-dichlorophenol results in increased phosphorylation of EIF2S1 protein
Enzyme Inhibitors promotes the reaction [2,4-dichlorophenol results in increased expression of EIF2S1 protein modified form]		 CTD PMID:25160872 PMID:27853103 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO 2,4-dichlorophenol results in increased expression of ERN1 mRNA CTD PMID:25160872 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO 2,4-dichlorophenol binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO 2,4-dichlorophenol results in increased expression of HSPA5 mRNA; 2,4-dichlorophenol results in increased expression of HSPA5 protein
ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 protein]		 CTD PMID:25160872 PMID:27853103 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions EXP 2,4-dichlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein] CTD PMID:16617682 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987 		JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO 2,4-dichlorophenol results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140 		JBrowse link
G Serpine1 serpin family E member 1 affects binding ISO 2,4-dichlorophenol binds to SERPINE1 protein CTD PMID:32278787 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO 2,4-dichlorophenol results in increased splicing of XBP1 mRNA CTD PMID:25160872 PMID:27853103 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
3,4-Dichlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rxrb retinoid X receptor beta increases activity ISO 3,4-dichlorophenol results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140 		JBrowse link
prothiofos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [prothiophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO prothiophos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO prothiophos results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [prothiophos results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO prothiophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO prothiophos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    chemical entity 19840
      molecular entity 19838
        polyatomic entity 19754
          heteroatomic molecular entity 19681
            halide 18104
              organohalogen compound 17857
                halophenol 1793
                  chlorophenol 1182
                    dichlorophenol 20
                      2,4-dichlorophenol + 20
                      2,5-dichlorophenol 0
                      2,6-dichlorophenol 0
                      3,4-Dichlorophenol 1
                      3,5-dichlorophenol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic molecule 19555
                              organic cyclic compound 19364
                                carbocyclic compound 18278
                                  benzenoid aromatic compound 17322
                                    benzenes 17065
                                      chlorobenzenes 13535
                                        chlorophenol 1182
                                          dichlorophenol 20
                                            2,4-dichlorophenol + 20
                                            2,5-dichlorophenol 0
                                            2,6-dichlorophenol 0
                                            3,4-Dichlorophenol 1
                                            3,5-dichlorophenol 0
paths to the root