Hspa5 (heat shock protein family A (Hsp70) member 5) - Rat Genome Database

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Gene: Hspa5 (heat shock protein family A (Hsp70) member 5) Rattus norvegicus
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Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
RGD ID: 2843
Description: Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and luteolysis. Acts upstream of or within response to endoplasmic reticulum stress. Located in several cellular components, including dendritic shaft; neuronal cell body; and smooth endoplasmic reticulum. Biomarker of post-traumatic stress disorder; steatotic liver disease (multiple); transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 78 kDa glucose-regulated protein; BIP; endoplasmic reticulum chaperone BiP; GRP 78; GRP-78; GRP78; heat shock 70 kDa protein 5; Heat shock 70kD protein 5; heat shock 70kDa protein 5 (glucose-regulated protein); heat shock protein 5; heat shock protein 70 family protein 5; heat shock protein family A member 5; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; steroidogenesis-activator polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,453,016 - 38,457,475 (+)NCBIGRCr8
mRatBN7.2318,055,507 - 18,059,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,055,405 - 18,059,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,123,611 - 21,128,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,708,632 - 29,713,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0327,962,245 - 27,966,702 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
RH 3.4 Map3151.7RGD
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-gambogic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,S)-Scoulerine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1-bromopropane  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-tert-butylhydroquinone  (ISO)
20-hydroxyecdysone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9H-xanthine  (EXP)
abamectin  (EXP)
acetylsalicylic acid  (ISO)
aconitic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
alcohol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxan  (ISO)
Aloe emodin  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-phellandrene  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
antimony(0)  (ISO)
antimycin A  (EXP,ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atorvastatin  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
aucubin  (ISO)
baicalein  (EXP)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
benomyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
boric acid  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP)
bufalin  (ISO)
bupropion  (ISO)
buspirone  (EXP)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calix[6]arene  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cantharidin  (EXP,ISO)
capsaicin  (ISO)
captan  (ISO)
carbaryl  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-V  (ISO)
chlordecone  (ISO)
chlorhexidine  (ISO)
chlormequat chloride  (EXP)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
Chloroacetonitrile  (ISO)
chlorobenzene  (ISO)
chloroethene  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cidofovir anhydrous  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
cobicistat  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP,ISO)
corilagin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytochalasin B  (EXP)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (EXP,ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
Dibromoacetonitrile  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
dicoumarol  (ISO)
Dienochlor  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
dihydrocapsaicin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
Dinitramine  (ISO)
dioscin  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
dizocilpine maleate  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental carbon  (ISO)
emodin  (EXP)
empagliflozin  (EXP)
endosulfan  (EXP,ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fangchinoline  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
fisetin  (ISO)
flavokawain B  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
formetanate  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furazolidone  (ISO)
Fusarenone X  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
gallium nitrate  (ISO)
gedunin  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
Glucogallin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine  (ISO)
glycine betaine  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
Guanabenz  (EXP,ISO)
GW 4064  (ISO)
hesperetin  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
ibuprofen  (EXP,ISO)
Ibutilide  (EXP)
icosanoid  (EXP)
imidacloprid  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
iodide salt  (EXP)
ionomycin  (ISO)
iprodione  (ISO)
iron dichloride  (ISO)
isoflavones  (EXP)
isoliquiritigenin  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketamine  (EXP,ISO)
KN-93  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-glutamine  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lanthanum atom  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
Licochalcone A  (ISO)
licoricidin  (ISO)
linagliptin  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
losartan  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
meglumine amidotrizoate  (EXP)
melatonin  (EXP)
menadione  (ISO)
menaquinone  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methomyl  (ISO)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
metyrapone  (ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
minocycline  (EXP)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
morusin  (ISO)
mycophenolic acid  (ISO)
myriocin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naloxone  (ISO)
naltrexone  (ISO)
naphthalene  (ISO)
naringin  (EXP)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nilotinib  (ISO)
nitric oxide  (ISO)
Nivalenol  (ISO)
nocodazole  (EXP)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP)
Norbinaltorphimine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleuropein  (EXP)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
oxycodone  (EXP,ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirimicarb  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(guanylic acid)  (EXP)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
proanthocyanidin  (EXP)
procaine  (ISO)
procymidone  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
Repaglinide  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
rimonabant  (ISO)
Roridin A  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
salvianolic acid B  (EXP)
saquinavir  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopoletin  (EXP)
selenomethionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
SNX-2112  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium disulfite  (EXP)
sodium fluoride  (EXP,ISO)
sorafenib  (ISO)
SR 144528  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP,ISO)
sunitinib  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
taurine  (ISO)
taurodeoxycholic acid  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
TEMPO  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
transplatin  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP,ISO)
U-73122  (ISO)
umbelliferone  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)
vemurafenib  (ISO)
vildagliptin  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
vitexin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
xylitol  (ISO)
Z-Val-Phe-H  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to antibiotic  (IEP)
cellular response to calcium ion  (IEP)
cellular response to cAMP  (IEP)
cellular response to gamma radiation  (IEP)
cellular response to glucose starvation  (IEA,ISO)
cellular response to interleukin-4  (IEA,ISO)
cellular response to manganese ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebellar Purkinje cell layer development  (IEA,ISO)
cerebellum structural organization  (IEA,ISO)
chaperone cofactor-dependent protein refolding  (IBA)
chromatin looping  (IEA)
chromatin remodeling  (IEA)
endoplasmic reticulum unfolded protein response  (IBA,IEA,ISO)
ER overload response  (IEA,ISO)
ERAD pathway  (IBA)
IRE1-mediated unfolded protein response  (ISO)
luteolysis  (IEP)
maintenance of protein localization in endoplasmic reticulum  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of IRE1-mediated unfolded protein response  (ISS)
negative regulation of PERK-mediated unfolded protein response  (IEA,ISO)
negative regulation of protein-containing complex assembly  (ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
neuron apoptotic process  (IEP)
neuron differentiation  (IEP)
positive regulation of cell migration  (IEA,ISO,ISS)
positive regulation of neuron projection development  (IMP)
positive regulation of protein ubiquitination  (IEA,ISO)
post-translational protein targeting to membrane, translocation  (IEA,ISO,ISS)
protein folding  (IEA)
protein refolding  (IBA)
proteolysis involved in protein catabolic process  (IEA,ISO)
response to cocaine  (IEP)
response to endoplasmic reticulum stress  (IDA,IEP)
response to methamphetamine hydrochloride  (IEP)
stress response to metal ion  (IEP)
substantia nigra development  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Ahn SM, etal., Psychopharmacology (Berl). 2007 Dec;195(3):407-14. Epub 2007 Sep 13.
2. Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons. Aoki T, etal., J Biochem. 1997 Jan;121(1):122-7.
3. The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Blass S, etal., Arthritis Rheum. 2001 Apr;44(4):761-71.
4. [Effect of electroacupuncture pretreatment on apoptotic neurons and expression of GRP 78 and GADD 153 in the hippocampus in rats with global cerebral ischemia/reperfusion injury]. Chen HL, etal., Zhen Ci Yan Jiu. 2014 Dec;39(6):431-6.
5. Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells. Cho YM, etal., Exp Mol Med. 2009 Jun 30;41(6):440-52. doi: 10.3858/emm.2009.41.6.049.
6. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Chouchani ET, etal., Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633.
7. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
8. Proteomic and PROTEOMEX profiling of mammary cancer progression in a HER-2/neu oncogene-driven animal model system. Croci S, etal., Proteomics. 2010 Nov;10(21):3835-53.
9. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Deuring JJ, etal., Biochem J. 2012 Jan 1;441(1):87-93.
10. Activation profiles of HSPA5 during the glomerular mesangial cell stress response to chemical injury. Falahatpisheh H, etal., Cell Stress Chaperones. 2007 Autumn;12(3):209-18.
11. Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment. Faure JJ, etal., Metab Brain Dis. 2009 Dec;24(4):685-700. doi: 10.1007/s11011-009-9167-0. Epub 2009 Oct 14.
12. [Protective effect of adenosine preconditioning against spinal cord ischemia-reperfusion injury in rats]. Fu Q, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jan;34(1):92-5.
13. Different early ER-stress responses in the CLN8(mnd) mouse model of neuronal ceroid lipofuscinosis. Galizzi G, etal., Neurosci Lett. 2011 Jan 25;488(3):258-62. Epub 2010 Nov 19.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Hayashi T and Su TP, Cell. 2007 Nov 2;131(3):596-610.
17. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Inokuchi Y, etal., Invest Ophthalmol Vis Sci. 2009 Jan;50(1):334-44. doi: 10.1167/iovs.08-2123. Epub 2008 Aug 29.
18. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
19. Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase. Kim CH, etal., J Biol Chem. 2011 Mar 18;286(11):9196-204. Epub 2011 Jan 5.
20. Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. Kuznetsov G, etal., J Biol Chem. 1994 Sep 16;269(37):22990-5.
21. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
22. Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. Li N, etal., Scand Cardiovasc J. 2019 Feb;53(1):42-47. doi: 10.1080/14017431.2018.1516891.
23. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
24. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
25. Immunization with Ovarian Autoantigens leads to Reduced Fertility in Mice following Follicular dysfunction. Mande PV, etal., Reproduction. 2011 Dec 5.
26. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. Mantuano E, etal., J Neurosci. 2011 Sep 21;31(38):13376-85.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Oligomerization properties of ERp29, an endoplasmic reticulum stress protein. Mkrtchian S, etal., FEBS Lett. 1998 Jul 24;431(3):322-6.
29. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
30. An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Munro S and Pelham HR, Cell 1986 Jul 18;46(2):291-300.
31. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura S, etal., J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Cloning and characterization of a novel GRP78-binding protein in the rat brain. Oh-hashi K, etal., J Biol Chem 2003 Mar 21;278(12):10531-7. Epub 2003 Jan 3.
34. Deletion of the Pro-Apoptotic Endoplasmic Reticulum Stress Response Effector CHOP Does Not Result in Improved Locomotor Function after Severe Contusive Spinal Cord Injury. Ohri SS, etal., J Neurotrauma. 2011 Nov 21.
35. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Penas C, etal., Cell Death Differ. 2011 Oct;18(10):1617-27. doi: 10.1038/cdd.2011.24. Epub 2011 Mar 25.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. Ravindran S, etal., J Biol Chem. 2008 Oct 31;283(44):29658-70. doi: 10.1074/jbc.M800786200. Epub 2008 Aug 28.
39. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, etal., J Neurosci. 2009 May 27;29(21):6883-96. doi: 10.1523/JNEUROSCI.4723-08.2009.
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells. Rosengren V, etal., J Cell Biochem. 2012 May;113(5):1635-44. doi: 10.1002/jcb.24032.
44. Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex. Sargsyan E, etal., J Biol Chem 2002 May 10;277(19):17009-15.
45. Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor. Satoh T, etal., J Neurochem. 2000 Sep;75(3):1092-102.
46. Hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver. Shi FH, etal., J Pharm Pharmacol. 2013 Jun;65(6):916-27. doi: 10.1111/jphp.12051. Epub 2013 Mar 25.
47. 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP. Srinivasan K and Sharma SS, Life Sci. 2012 Jan 16;90(3-4):154-60. Epub 2011 Oct 29.
48. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
49. Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis. Sukumaran V, etal., Int J Biol Sci. 2011;7(8):1077-92. Epub 2011 Sep 8.
50. ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Sun HL, etal., Exp Clin Endocrinol Diabetes. 2009 Jul;117(7):336-44. Epub 2009 Mar 19.
51. Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
52. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
53. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells. Tiwari A, etal., J Cell Sci. 2013 May 1;126(Pt 9):1962-8. doi: 10.1242/jcs.117374. Epub 2013 Feb 26.
54. Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis. Torres-Gonzalez E, etal., Am J Respir Cell Mol Biol. 2012 Jan 6.
55. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
56. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Wey S, etal., Blood. 2012 Jan 19;119(3):817-25. doi: 10.1182/blood-2011-06-357384. Epub 2011 Sep 21.
57. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
58. Association between glucose-regulated protein and neutrophil apoptosis in severe acute pancreatitis. Xu LT, etal., Int J Clin Exp Pathol. 2015 Aug 1;8(8):9300-6. eCollection 2015.
59. Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia. Yamaguchi A, etal., J Biol Chem 2002 Jan 4;277(1):623-9.
60. [Effects of acupuncture intervention on expression of glucose-regulated protein 78 and C/EBP homologous protein in hippocampal CA 1 region in rats with hyperspasmia]. Yang F, etal., Zhen Ci Yan Jiu. 2014 Aug;39(4):267-71.
61. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
62. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
63. Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons. Yu B, etal., BMC Neurosci. 2014 Oct 21;15:115. doi: 10.1186/s12868-014-0115-5.
64. ER stress induced by ionising radiation in IEC-6 cells. Zhang B, etal., Int J Radiat Biol. 2010 Jun;86(6):429-35. doi: 10.3109/09553001003668014.
65. Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways. Zhang LH, etal., Brain Res. 2011 Jan 31;1371:23-31. Epub 2010 Nov 25.
66. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Zhang XM, etal., Cell Res. 2015 Jul;25(7):818-36. doi: 10.1038/cr.2015.75. Epub 2015 Jun 19.
67. LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats. Zhao Q, etal., Heart Vessels. 2014 Sep;29(5):667-78. doi: 10.1007/s00380-013-0418-y. Epub 2013 Oct 16.
68. [Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats]. Zhao Y, etal., Zhonghua Yi Xue Za Zhi. 2014 Oct 21;94(38):3024-8.
69. Glucose regulated protein 78 is potentially an important player in the development of nonalcoholic steatohepatitis. Zhou X, etal., Gene. 2017 Dec 30;637:138-144. doi: 10.1016/j.gene.2017.09.051. Epub 2017 Sep 23.
Additional References at PubMed
PMID:3468506   PMID:3563495   PMID:7679955   PMID:8666824   PMID:8889548   PMID:9006956   PMID:9798653   PMID:10085239   PMID:10760948   PMID:11181571   PMID:11854325   PMID:11943137  
PMID:12065409   PMID:12411443   PMID:12475965   PMID:12646573   PMID:12665508   PMID:12826667   PMID:14960307   PMID:15166316   PMID:15294975   PMID:15308636   PMID:15452145   PMID:15489334  
PMID:15665855   PMID:15838258   PMID:16223484   PMID:16433633   PMID:16906134   PMID:17634366   PMID:17854840   PMID:17991893   PMID:18400946   PMID:18787714   PMID:18850735   PMID:18923430  
PMID:18953869   PMID:19056867   PMID:19103594   PMID:19199708   PMID:19218986   PMID:19363290   PMID:19411306   PMID:19503733   PMID:19720107   PMID:19769458   PMID:19816510   PMID:19946888  
PMID:20167237   PMID:20235454   PMID:20335166   PMID:20458337   PMID:21187406   PMID:21289099   PMID:21423176   PMID:21429313   PMID:21494687   PMID:21630459   PMID:21970967   PMID:22083547  
PMID:22206666   PMID:22342161   PMID:22460328   PMID:22589549   PMID:22640899   PMID:22689054   PMID:22783020   PMID:22837305   PMID:22926577   PMID:23106098   PMID:23174603   PMID:23175774  
PMID:23215692   PMID:23349634   PMID:23376485   PMID:23716698   PMID:23787763   PMID:23816873   PMID:23913443   PMID:23921388   PMID:23926254   PMID:23975754   PMID:23979707   PMID:23990668  
PMID:24030972   PMID:24334118   PMID:24475200   PMID:24508390   PMID:24625528   PMID:24643222   PMID:24768185   PMID:24880098   PMID:25279841   PMID:25468996   PMID:25863526   PMID:25885223  
PMID:26316108   PMID:26376412   PMID:26438849   PMID:26464674   PMID:26582200   PMID:26655470   PMID:26729625   PMID:27905509   PMID:28275724   PMID:29476059   PMID:29719251   PMID:29958740  
PMID:30155775   PMID:30217942   PMID:30431062   PMID:30486828   PMID:30895947   PMID:31904090   PMID:32357304   PMID:32657424   PMID:32794050   PMID:34597900   PMID:34767993   PMID:34898378  
PMID:35305213   PMID:35320827   PMID:35352799   PMID:37499993   PMID:38050647   PMID:38105649   PMID:39002476  


Genomics

Comparative Map Data
Hspa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,453,016 - 38,457,475 (+)NCBIGRCr8
mRatBN7.2318,055,507 - 18,059,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,055,405 - 18,059,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,123,611 - 21,128,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,708,632 - 29,713,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0327,962,245 - 27,966,702 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
RH 3.4 Map3151.7RGD
Cytogenetic Map3p11NCBI
HSPA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389125,234,853 - 125,241,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9125,234,853 - 125,241,382 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,997,132 - 128,003,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369127,036,953 - 127,043,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 349125,076,687 - 125,083,163NCBI
Celera998,645,114 - 98,651,649 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,609,713 - 97,616,253 (-)NCBIHuRef
CHM1_19128,146,874 - 128,153,413 (-)NCBICHM1_1
T2T-CHM13v2.09137,433,170 - 137,439,661 (-)NCBIT2T-CHM13v2.0
Hspa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,662,102 - 34,666,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,661,982 - 34,667,559 (+)EnsemblGRCm39 Ensembl
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,771,970 - 34,777,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBIMGSCv36mm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.94NCBI
Hspa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,055,420 - 3,062,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,055,420 - 3,060,208 (+)NCBIChiLan1.0ChiLan1.0
HSPA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,121,462 - 14,127,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1914,124,169 - 14,129,621 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0996,351,645 - 96,356,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19124,865,211 - 124,870,458 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,865,211 - 124,870,458 (-)Ensemblpanpan1.1panPan2
HSPA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1957,850,870 - 57,855,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl957,850,922 - 57,855,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,050,544 - 57,055,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0958,771,363 - 58,776,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl958,771,414 - 58,776,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1957,529,524 - 57,534,454 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0957,846,243 - 57,851,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0957,936,913 - 57,941,842 (+)NCBIUU_Cfam_GSD_1.0
Hspa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947193,579,938 - 193,584,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648713,348,465 - 13,352,717 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648713,348,465 - 13,352,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
HSPA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11212,920,705 - 12,925,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660793,184,743 - 3,190,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247609,986,656 - 9,995,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247609,986,529 - 9,991,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hspa5
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:48
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000025067
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
11528620Bss113Bone structure and strength QTL 1139.752e-10femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)31649064819241681Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
D2Wsu141e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,059,686 - 18,059,895 (+)MAPPERmRatBN7.2
Rnor_6.0313,842,481 - 13,842,689NCBIRnor6.0
Rnor_5.0319,162,051 - 19,162,259UniSTSRnor5.0
RGSC_v3.4313,787,796 - 13,788,004UniSTSRGSC3.4
Celera312,780,831 - 12,781,039UniSTS
Cytogenetic Map3p11UniSTS
RH94472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,059,718 - 18,059,876 (+)MAPPERmRatBN7.2
Rnor_6.0313,842,513 - 13,842,670NCBIRnor6.0
Rnor_5.0319,162,083 - 19,162,240UniSTSRnor5.0
RGSC_v3.4313,787,828 - 13,787,985UniSTSRGSC3.4
Celera312,780,863 - 12,781,020UniSTS
RH 3.4 Map3151.7UniSTS
Cytogenetic Map3p11UniSTS
D2Wsu17e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,059,658 - 18,059,863 (+)MAPPERmRatBN7.2
Rnor_6.0313,842,453 - 13,842,657NCBIRnor6.0
Rnor_5.0319,162,023 - 19,162,227UniSTSRnor5.0
RGSC_v3.4313,787,768 - 13,787,972UniSTSRGSC3.4
Celera312,780,803 - 12,781,007UniSTS
Cytogenetic Map3p11UniSTS
Hspa5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,059,672 - 18,059,805 (+)MAPPERmRatBN7.2
Rnor_6.0313,842,467 - 13,842,599NCBIRnor6.0
Rnor_5.0319,162,037 - 19,162,169UniSTSRnor5.0
RGSC_v3.4313,787,782 - 13,787,914UniSTSRGSC3.4
Celera312,780,817 - 12,780,949UniSTS
Cytogenetic Map3p11UniSTS
RH125368  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,059,164 - 18,059,437 (+)MAPPERmRatBN7.2
Rnor_6.0313,841,959 - 13,842,231NCBIRnor6.0
Rnor_5.0319,161,529 - 19,161,801UniSTSRnor5.0
RGSC_v3.4313,787,274 - 13,787,546UniSTSRGSC3.4
Celera312,780,309 - 12,780,581UniSTS
Cytogenetic Map3p11UniSTS
UniSTS:259180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,056,171 - 18,056,705 (+)MAPPERmRatBN7.2
Rnor_6.0313,838,969 - 13,839,502NCBIRnor6.0
Rnor_5.0319,158,539 - 19,159,072UniSTSRnor5.0
RGSC_v3.4313,784,284 - 13,784,817UniSTSRGSC3.4
Celera312,777,319 - 12,777,852UniSTS
Cytogenetic Map3p11UniSTS
HSPA5_988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,059,084 - 18,059,880 (+)MAPPERmRatBN7.2
Rnor_6.0313,841,879 - 13,842,674NCBIRnor6.0
Rnor_5.0319,161,449 - 19,162,244UniSTSRnor5.0
RGSC_v3.4313,787,194 - 13,787,989UniSTSRGSC3.4
Celera312,780,229 - 12,781,024UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025067   ⟹   ENSRNOP00000025064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,055,405 - 18,059,891 (+)Ensembl
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)Ensembl
RefSeq Acc Id: NM_013083   ⟹   NP_037215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,453,016 - 38,457,475 (+)NCBI
mRatBN7.2318,055,507 - 18,059,969 (+)NCBI
Rnor_6.0313,838,304 - 13,842,763 (+)NCBI
Rnor_5.0319,157,874 - 19,162,333 (+)NCBI
RGSC_v3.4313,783,825 - 13,788,022 (+)RGD
Celera312,776,654 - 12,781,113 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037215 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40817 (Get FASTA)   NCBI Sequence Viewer  
  AAH62017 (Get FASTA)   NCBI Sequence Viewer  
  EDL93169 (Get FASTA)   NCBI Sequence Viewer  
  EDL93170 (Get FASTA)   NCBI Sequence Viewer  
  EDL93171 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025064.5
GenBank Protein P06761 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037215   ⟸   NM_013083
- Peptide Label: precursor
- UniProtKB: P06761 (UniProtKB/Swiss-Prot),   A6JUC7 (UniProtKB/TrEMBL),   A0A8L2QDI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025064   ⟸   ENSRNOT00000025067

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06761-F1-model_v2 AlphaFold P06761 1-654 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692006
Promoter ID:EPDNEW_R2531
Type:single initiation site
Name:Hspa5_1
Description:heat shock protein family A member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0313,838,329 - 13,838,389EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2843 AgrOrtholog
BioCyc Gene G2FUF-50081 BioCyc
Ensembl Genes ENSRNOG00000018294 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025067.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621611 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIP_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25617 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72275 IMAGE-MGC_LOAD
NCBI Gene 25617 ENTREZGENE
PANTHER ENDOPLASMIC RETICULUM CHAPERONE BIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa5 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018294 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QDI1 ENTREZGENE, UniProtKB/TrEMBL
  A6JUC7 ENTREZGENE, UniProtKB/TrEMBL
  A6JUC8_RAT UniProtKB/TrEMBL
  BIP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Hspa5  heat shock protein family A (Hsp70) member 5  Hspa5  heat shock protein family A member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hspa5  heat shock protein family A member 5  Hspa5  heat shock protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Hspa5  heat shock protein 5  Hspa5  heat shock 70kDa protein 5 (glucose-regulated protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hspa5  heat shock 70kDa protein 5 (glucose-regulated protein)    heat shock 70kD protein 5  Name updated 1299863 APPROVED
2002-11-06 Hspa5  heat shock 70kD protein 5    Heat shock 70kD protein 5  Name updated 625702 APPROVED
2002-06-10 Hspa5  Heat shock 70kD protein 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization secreted into the endoplasmic reticulum 729154
gene_regulation released from antibody heavy chains by ATP 729154