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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDOzone results in increased expression of HSPA5 proteinPMID:29956773
Hspa5increases phosphorylationEXP 6480464CTDOzone results in increased phosphorylation of HSPA5 proteinPMID:33146391
Hspa5multiple interactionsEXP 6480464CTD[Ozone co-treated with Chlorine] results in decreased expression of HSPA5 mRNAPMID:18636392
Hspa5decreases expressionISOHSPA5 (Homo sapiens)6480464CTDOzone results in decreased expression of HSPA5 mRNAPMID:23033980
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDOzone results in increased expression of HSPA5 mRNAPMID:21543283
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