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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843 Species: Rattus norvegicus RGD Object: Gene Symbol: Hspa5 Name: heat shock protein 5

Acc ID: CHEBI:20993 Term: aldehydo-D-glucosamine Definition: The open-chain form of D-glucosamine. CasRN: 3416-24-8 Chemical ID: MESH:D005944

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736447	6480464	CTD	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA] tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	PMID:20165829
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 mRNA	PMID:19383982 PMID:16380481 PMID:20165829
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 protein	PMID:15618547 PMID:16380481 PMID:19383982
decreases expression	ISO	RGD:10742	6480464	CTD	Glucosamine results in decreased expression of HSPA5 mRNA	PMID:17178593
increases expression	EXP		6480464	CTD	Glucosamine results in increased expression of HSPA5 mRNA	PMID:20165829
multiple interactions	EXP		6480464	CTD	tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA] 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	PMID:20165829
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 mRNA	PMID:16380481 PMID:20165829 PMID:19383982
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 protein	PMID:16380481 PMID:19383982 PMID:15618547
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 mRNA	PMID:16380481 PMID:19383982 PMID:20165829
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 protein	PMID:16380481 PMID:15618547 PMID:19383982
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 mRNA	PMID:19383982 PMID:20165829 PMID:16380481
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 protein	PMID:15618547 PMID:16380481 PMID:19383982 PMID:22020377
increases expression	ISO	RGD:736447	6480464	CTD	Glucosamine results in increased expression of HSPA5 mRNA	PMID:16380481 PMID:19383982 PMID:20165829 PMID:22020377