Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5affects bindingEXP 6480464CTDlead acetate binds to HSPA5 proteinPMID:10702365
Hspa5affects expressionEXP 6480464CTDlead acetate affects the expression of HSPA5 mRNAPMID:15111246
Hspa5affects localizationEXP 6480464CTDlead acetate affects the localization of HSPA5 proteinPMID:21815057
Hspa5increases expressionEXP 6480464CTDlead acetate results in increased expression of HSPA5 mRNA; lead acetate results in increased expression of HSPA5 proteinPMID:10702365 PMID:17915553 PMID:22811615 PMID:25088297 PMID:30445054
Hspa5multiple interactionsEXP 6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of HSPA5 mRNA; ATP7A protein modified form inhibits the reaction [lead acetate binds to HSPA5 protein]; Cycloheximide inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; lead acetate inhibits the reaction [HSPA5 protein binds to FOS enhancer]; lead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer]; lead acetate results in increased expression of and results in increased activity of HSPA5 protein; Nickel inhibits the reaction [lead acetate binds to HSPA5 protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]; Zinc inhibits the reaction [lead acetate binds to HSPA5 protein]PMID:10702365 PMID:15111246 PMID:17915553 PMID:25088297 PMID:36642386
Go Back to source page   Continue to Ontology report