GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | affects binding | EXP | | 6480464 | CTD | lead acetate binds to HSPA5 protein | PMID:10702365 | Hspa5 | affects expression | EXP | | 6480464 | CTD | lead acetate affects the expression of HSPA5 mRNA | PMID:15111246 | Hspa5 | affects localization | EXP | | 6480464 | CTD | lead acetate affects the localization of HSPA5 protein | PMID:21815057 | Hspa5 | increases expression | EXP | | 6480464 | CTD | lead acetate results in increased expression of HSPA5 mRNA; lead acetate results in increased expression of HSPA5 protein | PMID:10702365 PMID:17915553 PMID:22811615 PMID:25088297 PMID:30445054 | Hspa5 | multiple interactions | EXP | | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in decreased expression of HSPA5 mRNA; ATP7A protein modified form inhibits the reaction [lead acetate binds to HSPA5 protein]; Cycloheximide inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; lead acetate inhibits the reaction [HSPA5 protein binds to FOS enhancer]; lead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer]; lead acetate results in increased expression of and results in increased activity of HSPA5 protein; Nickel inhibits the reaction [lead acetate binds to HSPA5 protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]; Zinc inhibits the reaction [lead acetate binds to HSPA5 protein] | PMID:10702365 PMID:15111246 PMID:17915553 PMID:25088297 PMID:36642386 | |
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