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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases response to substanceISOHSPA5 (Homo sapiens)6480464CTDHSPA5 results in decreased susceptibility to BortezomibPMID:20546536
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDBortezomib results in increased expression of HSPA5 mRNAPMID:15509775
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDBortezomib results in increased expression of HSPA5; Bortezomib results in increased expression of HSPA5 mRNA; Bortezomib results in increased expression of HSPA5 proteinPMID:15141013 PMID:15509775 PMID:16024631 PMID:16357177 PMID:18723477 PMID:20110775 PMID:20546536 PMID:20977926 PMID:21762082 PMID:24291039
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDBortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Bortezomib inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Bortezomib promotes the reaction [gambogic acid results in increased expression of HSPA5 protein]; Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; gambogic acid promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]; MYC protein promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]PMID:15141013 PMID:16357177 PMID:18641367 PMID:18723477 PMID:24291039
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