Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2843
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Hspa5
Name:	heat shock protein family A (Hsp70) member 5

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Hspa5	affects expression	EXP		6480464	CTD	Cisplatin affects the expression of HSPA5 protein	PMID:20071420
Hspa5	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of HSPA5 mRNA; Cisplatin results in increased expression of HSPA5 protein	PMID:23603837 PMID:37561086
Hspa5	multiple interactions	EXP		6480464	CTD	[Cisplatin co-treated with isoliquiritigenin] results in increased expression of HSPA5 mRNA; Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA]; Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of HSPA5 protein]	PMID:23603837 PMID:37561086
Hspa5	decreases expression	ISO	Hspa5 (Mus musculus)	6480464	CTD	Cisplatin results in decreased expression of HSPA5 mRNA	PMID:21151649
Hspa5	decreases expression	ISO	HSPA5 (Homo sapiens)	6480464	CTD	Cisplatin results in decreased expression of HSPA5 mRNA	PMID:11099651 PMID:25596134 PMID:27594783
Hspa5	increases expression	ISO	Hspa5 (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of HSPA5 mRNA	PMID:32567747
Hspa5	increases expression	ISO	HSPA5 (Homo sapiens)	6480464	CTD	Cisplatin results in increased expression of HSPA5 mRNA; Cisplatin results in increased expression of HSPA5 protein	PMID:16357177 PMID:19561079
Hspa5	multiple interactions	ISO	Hspa5 (Mus musculus)	6480464	CTD	Linagliptin inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA]	PMID:32567747
Hspa5	multiple interactions	ISO	HSPA5 (Homo sapiens)	6480464	CTD	[Cisplatin co-treated with Quercetin] results in increased expression of HSPA5 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of HSPA5 mRNA; HSPA5 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; HSPA5 protein affects the reaction [Cisplatin results in increased cleavage of PARP1 protein]	PMID:27234046 PMID:27514524 PMID:30871063

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