GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | decreases expression | EXP | | 6480464 | CTD | Acetylcysteine results in decreased expression of HSPA5 protein | PMID:27484784 | Hspa5 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein] | PMID:21145380 PMID:21198628 PMID:24291486 PMID:27484784 PMID:28296042 PMID:30633982 | Hspa5 | increases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in increased expression of HSPA5 protein | PMID:19722195 | Hspa5 | multiple interactions | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] | PMID:20493918 PMID:21533816 PMID:21911445 PMID:24157283 PMID:25451595 PMID:31330229 | Hspa5 | multiple interactions | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | 4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ethylmercury Compounds affects the expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [hesperetin results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]] | PMID:24802810 PMID:25341683 PMID:25950987 PMID:26772155 PMID:27511942 PMID:27784618 PMID:27816613 PMID:28754437 PMID:30502353 PMID:31276663 PMID:32506763 PMID:32590070 PMID:34687772 PMID:37148176 PMID:37487865 | | ||||||||||||||||||||||
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