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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5affects expressionEXP 6480464CTDLead affects the expression of HSPA5 mRNAPMID:15111246
Hspa5affects localizationEXP 6480464CTDLead affects the localization of HSPA5 proteinPMID:24431214
Hspa5increases expressionEXP 6480464CTDLead results in increased expression of HSPA5 proteinPMID:19161237 PMID:20020935 PMID:24431214
Hspa5multiple interactionsEXP 6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of HSPA5 mRNA; HSPA5 protein affects the reaction [Lead results in decreased expression of OCLN protein]; HSPA5 protein affects the reaction [Lead results in increased phosphorylation of SRC protein]; Lead inhibits the reaction [HSPA5 protein binds to FOS enhancer]; Lead inhibits the reaction [HSPA5 protein binds to HRAS enhancer]; Lead results in increased expression of and results in increased activity of HSPA5 proteinPMID:15111246 PMID:24431214 PMID:36642386
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDLead results in increased expression of HSPA5 mRNAPMID:11032763
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