GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | increases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Chlordecone results in increased expression of HSPA5 mRNA; Chlordecone results in increased expression of HSPA5 protein | PMID:17640991 | Hspa5 | increases response to substance | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | HSPA5 protein results in increased susceptibility to Chlordecone | PMID:17640991 | Hspa5 | multiple interactions | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | [Chlordecone co-treated with fulvestrant] results in increased expression of HSPA5 protein; Chlordecone promotes the reaction [ESR1 protein binds to HSPA5 protein]; ESR1 protein affects the reaction [HSPA5 protein results in increased susceptibility to Chlordecone] | PMID:17640991 | |
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