GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of HSPA5 mRNA | PMID:30261314 | Hspa5 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of HSPA5 protein | PMID:28495616 PMID:34392583 PMID:35152301 | Hspa5 | multiple interactions | EXP | | 6480464 | CTD | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein] | PMID:28495616 PMID:34392583 PMID:35152301 | Hspa5 | affects expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the expression of HSPA5 protein | PMID:29385562 | Hspa5 | increases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of HSPA5 mRNA | PMID:17680992 PMID:29803840 | Hspa5 | multiple interactions | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] | PMID:16298333 | |
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