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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5affects expressionEXP 6480464CTDT-2 Toxin affects the expression of HSPA5 proteinPMID:26141394
Hspa5increases expressionEXP 6480464CTDT-2 Toxin results in increased expression of HSPA5 mRNA; T-2 Toxin results in increased expression of HSPA5 proteinPMID:29454614 PMID:34673134
Hspa5multiple interactionsEXP 6480464CTDSelenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]PMID:29454614
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDT-2 Toxin results in increased expression of HSPA5 mRNA; T-2 Toxin results in increased expression of HSPA5 proteinPMID:31170431 PMID:34673134
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDT-2 Toxin results in increased expression of HSPA5 mRNA; T-2 Toxin results in increased expression of HSPA5 proteinPMID:31170431 PMID:34673134
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTDsalubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]; T-2 Toxin results in increased degradation of and results in decreased expression of HSPA5 proteinPMID:19336499 PMID:34673134
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDsalubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; salubrinal inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]PMID:34673134
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