GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of HSPA5 protein | PMID:21145380 | Hspa5 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein] | PMID:21145380 | Hspa5 | affects response to substance | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | HSPA5 protein affects the susceptibility to Arsenic Trioxide | PMID:19695276 | Hspa5 | decreases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of HSPA5 mRNA | PMID:24356939 PMID:25424538 | Hspa5 | increases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of HSPA5 mRNA; Arsenic Trioxide results in increased expression of HSPA5 protein | PMID:21533816 PMID:23892647 PMID:24157283 PMID:27461142 PMID:27638049 PMID:34091186 | Hspa5 | increases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of HSPA5 mRNA; Arsenic Trioxide results in increased expression of HSPA5 protein | PMID:11678611 PMID:19695276 PMID:22959511 PMID:23883479 PMID:26772155 PMID:34560123 | Hspa5 | multiple interactions | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; antimony trichloride promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]; Arsenic Trioxide promotes the reaction [antimony trichloride results in increased expression of HSPA5 mRNA]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased degradation of CASP12 protein]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein] | PMID:21533816 PMID:23892647 PMID:24157283 PMID:27638049 PMID:34091186 | Hspa5 | multiple interactions | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with Dactinomycin] results in decreased expression of HSPA5 mRNA; [Arsenic Trioxide co-treated with Dactinomycin] results in increased expression of HSPA5 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of HSPA5 mRNA]; Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]; Atrazine promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]; Cycloheximide inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; KIRA6 inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; selonsertib inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein] | PMID:11678611 PMID:23883479 PMID:26772155 PMID:34560123 | | ||||||||||||||||||||||
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