GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of HSPA5 mRNA | PMID:24349266 | Hspa5 | increases expression | EXP | | 6480464 | CTD | Glucose deficiency results in increased expression of HSPA5 protein; Glucose results in increased expression of HSPA5 protein | PMID:21337367 PMID:34801538 | Hspa5 | multiple interactions | EXP | | 6480464 | CTD | Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [Glucose results in increased expression of HSPA5 protein] | PMID:34801538 | Hspa5 | decreases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Glucose results in decreased expression of HSPA5 mRNA | PMID:17178593 | Hspa5 | increases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of HSPA5 mRNA; Glucose results in increased expression of HSPA5 protein | PMID:30076216 | Hspa5 | increases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Glucose deficiency results in increased expression of HSPA5 mRNA; Glucose deficiency results in increased expression of HSPA5 protein; Glucose results in increased expression of HSPA5 mRNA; Glucose results in increased expression of HSPA5 protein | PMID:12147617 PMID:16380481 PMID:25451566 PMID:31022492 | Hspa5 | multiple interactions | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | 2-aminoethoxydiphenyl borate inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Gadolinium inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Glucose affects the reaction [bisphenol A results in decreased expression of HSPA5 protein]; waixenicin A inhibits the reaction [Glucose results in increased expression of HSPA5 protein] | PMID:21705745 PMID:30076216 | Hspa5 | multiple interactions | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 mRNA]; 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]; [Glucose co-treated with TGFB1 protein] results in increased expression of HSPA5 protein; ATF6 protein modified form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of HSPA5 protein]; glucogallin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; XBP1 mRNA alternative form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]] | PMID:25451566 PMID:31022492 PMID:35961541 | |
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