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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases expressionEXP 6480464CTDGlucose results in decreased expression of HSPA5 mRNAPMID:24349266
Hspa5increases expressionEXP 6480464CTDGlucose deficiency results in increased expression of HSPA5 protein; Glucose results in increased expression of HSPA5 proteinPMID:21337367 PMID:34801538
Hspa5multiple interactionsEXP 6480464CTDChlorogenic Acid inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]PMID:34801538
Hspa5decreases expressionISOHspa5 (Mus musculus)6480464CTDGlucose results in decreased expression of HSPA5 mRNAPMID:17178593
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDGlucose results in increased expression of HSPA5 mRNA; Glucose results in increased expression of HSPA5 proteinPMID:30076216
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDGlucose deficiency results in increased expression of HSPA5 mRNA; Glucose deficiency results in increased expression of HSPA5 protein; Glucose results in increased expression of HSPA5 mRNA; Glucose results in increased expression of HSPA5 proteinPMID:12147617 PMID:16380481 PMID:25451566 PMID:31022492
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Gadolinium inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Glucose affects the reaction [bisphenol A results in decreased expression of HSPA5 protein]; waixenicin A inhibits the reaction [Glucose results in increased expression of HSPA5 protein]PMID:21705745 PMID:30076216
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 mRNA]; 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]; [Glucose co-treated with TGFB1 protein] results in increased expression of HSPA5 protein; ATF6 protein modified form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of HSPA5 protein]; glucogallin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]; XBP1 mRNA alternative form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]PMID:25451566 PMID:31022492 PMID:35961541
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