GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | decreases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Folic Acid results in decreased expression of HSPA5 mRNA | PMID:25629700 | Hspa5 | decreases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Folic Acid deficiency results in decreased expression of HSPA5 protein | PMID:28639913 | Hspa5 | multiple interactions | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HSPA5 protein; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HSPA5 gene; [Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HSPA5 protein]; Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of HSPA5 mRNA] | PMID:20938992 PMID:22206623 PMID:23439872 PMID:37263574 | Hspa5 | multiple interactions | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | [Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HSPA5 protein] | PMID:37263574 | |
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