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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDTamoxifen results in increased expression of HSPA5 mRNAPMID:19400957
Hspa5affects expressionISOHspa5 (Mus musculus)6480464CTDTamoxifen affects the expression of HSPA5 mRNAPMID:17555576
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDTamoxifen results in increased expression of HSPA5 mRNAPMID:19400957
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDTamoxifen results in increased expression of HSPA5 proteinPMID:19812351
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTDTamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein]; Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]PMID:23038002
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDTamoxifen promotes the reaction [Nelfinavir results in increased expression of HSPA5 protein]PMID:20594311
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