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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases methylationEXP 6480464CTDChlorpyrifos results in increased methylation of HSPA5 genePMID:32905263
Hspa5decreases expressionISOHSPA5 (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of HSPA5 mRNAPMID:25424538
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of HSPA5 mRNAPMID:22515965
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of HSPA5 proteinPMID:27993609
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