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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDCyclosporine results in increased expression of HSPA5 mRNA; Cyclosporine results in increased expression of HSPA5 proteinPMID:20136702 PMID:25596134 PMID:35033536
Hspa5multiple interactionsEXP 6480464CTDMelatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]PMID:20136702
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDCyclosporine results in increased expression of HSPA5 mRNA; Cyclosporine results in increased expression of HSPA5 proteinPMID:22155090 PMID:23308384 PMID:25047351
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDCyclosporine results in increased expression of HSPA5 mRNA; Cyclosporine results in increased expression of HSPA5 proteinPMID:19159671 PMID:20106945 PMID:21163907 PMID:21632981 PMID:24973091 PMID:25562108 PMID:25596134 PMID:27358234 PMID:27989131 PMID:32152650 PMID:34681664 PMID:35033536
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Cyclosporine results in increased expression of HSPA5 protein]PMID:22155090
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of HSPA5 mRNAPMID:32152650
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