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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5multiple interactionsEXP 6480464CTDNicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]PMID:18477628 PMID:28082123
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDNicotine results in increased expression of HSPA5PMID:24201001
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTDNicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]PMID:28082123
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