Gene:	Insr ( Rattus norvegicus ) insulin receptor
Description:	a receptor for insulin, involved in intracellular signaling, protein and auto-phosphorylation, regulation of gene expression and other processes; associated with diabetes, human homolog associated with cancers, cardiomegaly and other diseases; part of the altered leptin system pathway
ArrayIDs:	1369051_at; 6703468; 6152845; M29014_at; 6696301; 6600299; 6120762; 5674268; 5993210; 6319485; 6399363; 6609186; 6342171; 6676202; 6493844; 6010050; 6673749; 6197673; 5940963; 6548549; 6297052; 5927139; 6101679; 6075288; 5740699; 6221062; 6042521; 6112102;  (details...)
Gene Type:	protein-coding
Strain:	LEW-Tg(FH1t(Insr)UTG)87Hrjb  LEW-Tg(FH1t(Insr)UTG)4Hrjb
Additional Data
Homologs
Homo sapiens: INSR     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Insr     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Insr genome assembly 3.1 12 2934966 - 3087691     Rat Celera Assembly 12 3053590 - 3185991     RGSC genome assembly v3.4 12 2934967 - 3087691     Cytogenetic 12 q12 Mus musculus Insr Mouse genome assembly build 36.1 8 3153235 - 3154602     Cytogenetic 8 8 A1.1 Homo sapiens INSR human genome assembly 19 7067637 - 7245011     Human genome assembly build 36.2 19 7067638 - 7245011     Cytogenetic 19 p13.3-p13.2   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Note Reference binds insulin and has a tyrosine-protein kinase activity 61488 Gene Ontology GTP binding,  SH2 domain binding,  protein phosphatase binding ...  (details...)
Biological Process	Gene Ontology positive regulation of protein kinase B signaling cascade,  positive regulation of nitric oxide biosynthetic process,  positive regulation of mitosis ...  (details...)
Cellular Component	Gene Ontology synapse,  nucleus,  endosome ...  (details...)
Disease	Note Reference mutation may lead to insulin resistance 61488 Ontology Lipodystrophy,  Hyperinsulinemia,  Diabetes Mellitus ...  (details...)
Phenotype	Ontology increased circulating leptin level,  postnatal growth retardation,  increased circulating insulin level ...  (details...)
Pathway	Ontology altered insulin signaling pathway,  type 2 diabetes mellitus pathway,  altered leptin system pathway ...  (details...)
Regulation	Note Reference rapid tyrosine phosphorylation is induced by insulin in primary adipocytes 727426
External Links
Databases	DATABASE ID SOURCE SMART: TyrKc IPI SMART: FU IPI SMART: FN3 IPI PROSITE: RECEPTOR_TYR_KIN_II IPI PROSITE: PROTEIN_KINASE_TYR IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: FN3 IPI UNIPARC: UPI000195114A IPI UNIPARC: UPI0001B7991B IPI UNIPARC: UPI000012D6AE IPI KEGG Report: rno:24954 ENTREZGENE HomoloGene Group ID: 20090 ENTREZGENE Germonline: 2917 Pfam: Recep_L_domain IPI Pfam: Pkinase_Tyr IPI Pfam: Furin-like IPI Pfam: fn3 IPI KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04520 ENTREZGENE InterPro: Tyr_prot_kinase_subgr_cat_dom. IPI InterPro: Tyr_prot_kinase_rcpt_2_CS. IPI InterPro: Tyr_prot_kinase_cat_dom. IPI InterPro: Tyr_prot_kinase_AS. IPI InterPro: Tyr_prot_kinase. IPI InterPro: Tyr_kinase_insulin_rcpt. IPI InterPro: Tyr_kinase_insulin-like_rcpt. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Kinase-like_dom. IPI InterPro: Growth_fac_rcpt. IPI InterPro: Furin_repeat. IPI InterPro: Furin-like. IPI InterPro: FN_III. IPI InterPro: Fibronectin_typ-III-like_fold. IPI InterPro: EGF_rcpt_L. IPI Ensembl Protein: ENSRNOP00000049655 IPI Ensembl Protein: ENSRNOP00000060141 IPI Ensembl Protein: ENSRNOP00000046668 IPI IPI: IPI00393267 IPI IPI: IPI00949768 IPI IPI: IPI00563042 IPI Gene3D-CATH: FN_III-like IPI Entrez Gene: Insr ENTREZGENE PIRSF: Insulin_receptor IPI UniProt: Q9WVI3_RAT IPI UniProt: Q9WVI2_RAT IPI UniProt: Q9R1H7_RAT IPI UniProt: Q9R1H6_RAT IPI UniProt: Q9R1H5_RAT IPI UniProt: Q9R1H4_RAT IPI UniProt: Q9R1H3_RAT IPI UniProt: Q9R1H2_RAT IPI UniProt: Q9R1H1_RAT IPI UniProt: Q9R1H0_RAT IPI UniProt: Q9R1G9_RAT IPI UniProt: Q9R1G8_RAT IPI UniProt: Q6Q2A2_RAT IPI UniProt: INSR_RAT IPI UniProt: INSR_RAT IPI Ensembl Genes: ENSRNOG00000029986 IPI RatMap: 35168 ENTREZGENE Superfamily-SCOP: Kinase_like IPI Superfamily-SCOP: Grow_fac_recept IPI Superfamily-SCOP: FN_III-like IPI PANTHER: Tyr_prot_kinase IPI PANTHER: Tyr_kinase_insulin_rcpt IPI
Sequences	Nucleotide: M29014 Get FASTA Search GEO Profiles Nucleotide: AY566293 Get FASTA Search GEO Profiles Nucleotide: U80630 Get FASTA Search GEO Profiles Nucleotide: U80629 Get FASTA Search GEO Profiles Nucleotide: CH474084 Get FASTA Search GEO Profiles Nucleotide: AF110222 Get FASTA Search GEO Profiles Nucleotide: AF110220 Get FASTA Search GEO Profiles Nucleotide: AF110219 Get FASTA Search GEO Profiles Nucleotide: AF110218 Get FASTA Search GEO Profiles Nucleotide: AF110217 Get FASTA Search GEO Profiles Nucleotide: AF110216 Get FASTA Search GEO Profiles Nucleotide: AF110214 Get FASTA Search GEO Profiles Nucleotide: AF110213 Get FASTA Search GEO Profiles Nucleotide: AF110212 Get FASTA Search GEO Profiles Nucleotide: AF110211 Get FASTA Search GEO Profiles Nucleotide: AF110210 Get FASTA Search GEO Profiles Nucleotide: AF110209 Get FASTA Search GEO Profiles Nucleotide: AF110208 Get FASTA Search GEO Profiles Nucleotide: AF110207 Get FASTA Search GEO Profiles Nucleotide: AF110206 Get FASTA Search GEO Profiles Nucleotide: AF110205 Get FASTA Search GEO Profiles Nucleotide: AF110204 Get FASTA Search GEO Profiles Nucleotide: AF110203 Get FASTA Search GEO Profiles Nucleotide: AF110202 Get FASTA Search GEO Profiles Nucleotide: AF110201 Get FASTA Search GEO Profiles Nucleotide: AF110200 Get FASTA Search GEO Profiles Nucleotide: AF005777 Get FASTA Search GEO Profiles Nucleotide: AF005776 Get FASTA Search GEO Profiles Nucleotide: NM_017071 Get FASTA Search GEO Profiles (View all 29 Nucleotide Accessions) Protein: Q9WVI3 Get FASTA Protein: Q9WVI2 Get FASTA Protein: Q9R1H7 Get FASTA Protein: Q9R1H6 Get FASTA Protein: Q9R1H5 Get FASTA Protein: Q9R1H4 Get FASTA Protein: Q9R1H3 Get FASTA Protein: Q9R1H2 Get FASTA Protein: Q9R1H1 Get FASTA Protein: Q9R1H0 Get FASTA Protein: Q9R1G9 Get FASTA Protein: Q9R1G8 Get FASTA Protein: Q6Q2A2 Get FASTA Protein: P15127 Get FASTA Protein: AAA41441 Get FASTA Protein: AAT00542 Get FASTA Protein: AAB38967 Get FASTA Protein: EDL74925 Get FASTA Protein: EDL74924 Get FASTA Protein: EDL74923 Get FASTA Protein: AAD40897 Get FASTA Protein: AAD40896 Get FASTA Protein: AAD40895 Get FASTA Protein: AAD40894 Get FASTA Protein: AAD40893 Get FASTA Protein: AAD40892 Get FASTA Protein: AAD40891 Get FASTA Protein: AAD40890 Get FASTA Protein: AAD40889 Get FASTA Protein: AAD40888 Get FASTA Protein: AAD40887 Get FASTA Protein: AAD40886 Get FASTA Protein: AAB61415 Get FASTA Protein: AAB61414 Get FASTA Protein: NP_058767 Get FASTA (View all 35 Protein Accessions)
Clusters	UniGene: 9876
References
Curated References	63 references in RGD related to Insr
Other References	63 other references at PubMed related to Insr
Database Information
RGD ID	2917
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Insr insulin receptor APPROVED Symbol and Name status set to approved 70586