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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrdecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of INSR mRNA; Diethylhexyl Phthalate results in decreased expression of INSR proteinPMID:21911000 PMID:25280772 PMID:28025108 PMID:30597186 PMID:35460826
Insrincreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of INSR mRNAPMID:21911000
Insrincreases methylationEXP 6480464CTDDiethylhexyl Phthalate results in increased methylation of INSR promoterPMID:30597186
Insrmultiple interactionsEXP 6480464CTD4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR mRNA]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR protein]; [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of INSR mRNA]; [INS1 protein co-treated with Diethylhexyl Phthalate] results in decreased expression of and results in decreased phosphorylation of INSR protein; Diethylhexyl Phthalate results in decreased expression of and results in decreased phosphorylation of INSR protein; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR protein]PMID:21911000 PMID:25280772 PMID:28526321 PMID:35460826
Insrdecreases expressionISOINSR (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of INSR proteinPMID:28025108
Insrincreases expressionISOInsr (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of INSR mRNAPMID:35550907
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNAPMID:28433925
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