Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 46, XY Disorders of Sex Development | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: 46 and XY disorder of sex development | ClinVar | | diabetes mellitus | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Monogenic diabetes | ClinVar | PMID:10084586 more ... | Donohue syndrome | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10084586 more ... | esophageal atresia | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Esophageal atresia | ClinVar | | familial hyperinsulinemic hypoglycemia 4 | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Hyperinsulinism due to glutamodehydrogenase deficiency | ClinVar | PMID:15161766 more ... | familial hyperinsulinemic hypoglycemia 4 | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:15161766 more ... | familial hyperinsulinemic hypoglycemia 5 | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:15161766 more ... | genetic disease | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:2211730 more ... | Insulin Resistance | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10084586 more ... | Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10084586 more ... | maturity-onset diabetes of the young type 1 | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Type 2 diabetes mellitus | ClinVar | PMID:10084586 more ... | mucolipidosis type IV | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Mucolipidosis type IV | ClinVar | PMID:11030752 more ... | Native American myopathy | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Congenital myopathy cleft palate and malignant hyperthermia | ClinVar | PMID:10084586 more ... | PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10084586 more ... | type 2 diabetes mellitus | | ISO | INSR (Homo sapiens) | 8554872 | ClinVar more ... | ClinVar | PMID:10084586 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Upregulation of the insulin receptor and type I insulin-like growth factor receptor are early events in hepatocarcinogenesis. | Aleem E, etal., Toxicol Pathol. 2011 Apr;39(3):524-43. doi: 10.1177/0192623310396905. Epub 2011 Mar 16. |
| 2. | Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. | Araujo EP, etal., FEBS Lett 2002 Nov 20;531(3):437-42. |
| 3. | Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. | Barbuio R, etal., J Endocrinol. 2007 Sep;194(3):539-50. |
| 4. | Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. | Belke DD, etal., J Clin Invest 2002 Mar;109(5):629-39. |
| 5. | Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. | Ben Lulu S, etal., Pediatr Surg Int. 2010 Jan;26(1):37-44. doi: 10.1007/s00383-009-2520-x. |
| 6. | Impaired insulin action but normal insulin receptor activity in diabetic rat liver: effect of vanadate. | Blondel O, etal., Am J Physiol. 1990 Mar;258(3 Pt 1):E459-67. doi: 10.1152/ajpendo.1990.258.3.E459. |
| 7. | Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. | Bluher M, etal., Dev Cell 2002 Jul;3(1):25-38. |
| 8. | The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. | Boutchueng-Djidjou M, etal., Mol Cell Proteomics. 2015 Apr;14(4):1079-92. doi: 10.1074/mcp.M114.047159. Epub 2015 Feb 16. |
| 9. | Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring. | Breton C, etal., Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E462-72. Epub 2008 Dec 16. |
| 10. | Insulin receptors in developing rat liver: acquisition of down regulation in the immediate postnatal period. | Caliendo AM and Patel MS, Arch Biochem Biophys. 1983 Dec;227(2):552-61. doi: 10.1016/0003-9861(83)90484-8. |
| 11. | Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. | Calle C, etal., BMC Mol Biol. 2008 Jul 18;9:65. |
| 12. | Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. | Chettouh H, etal., Cancer Res. 2013 Jul 1;73(13):3974-86. doi: 10.1158/0008-5472.CAN-12-3824. Epub 2013 Apr 30. |
| 13. | Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. | Colomiere M, etal., Eur J Endocrinol. 2009 Apr;160(4):567-78. Epub 2009 Jan 29. |
| 14. | Culture and differentiation of preadipocytes in two-dimensional and three-dimensional in vitro systems. | Daya S, etal., Differentiation. 2007 Jun;75(5):360-70. Epub 2007 Feb 5. |
| 15. | Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage. | de Borst MH, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F428-37. Epub 2007 Apr 11. |
| 16. | Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. | De Felice FG, etal., Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2. |
| 17. | The nonclassical insulin binding of insulin receptors from rat liver is due to the presence of two interacting alpha-subunits in the receptor complex. | Deger A, etal., Biochem Biophys Res Commun. 1986 Mar 13;135(2):458-64. |
| 18. | Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver. | Desbuquois B, etal., FEBS J. 2008 Sep;275(17):4363-77. Epub 2008 Jul 24. |
| 19. | IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. | Diaz LE, etal., Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6. |
| 20. | Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis. | Diesel B, etal., Biochemistry. 2007 Feb 27;46(8):2146-55. Epub 2007 Feb 3. |
| 21. | Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy. | Ding S, etal., Toxicol Sci. 2017 Oct 1;159(2):290-306. doi: 10.1093/toxsci/kfx093. |
| 22. | Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease. | Dongiovanni P, etal., Clin Sci (Lond). 2017 Jun 7;131(12):1301-1315. doi: 10.1042/CS20170175. Print 2017 Jun 1. |
| 23. | Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. | Eisenberg ML, etal., Cell Physiol Biochem. 2005;15(1-4):51-8. |
| 24. | Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. | Evert M, etal., Cancer Res. 2004 Nov 1;64(21):8093-100. |
| 25. | Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition. | Feres NH, etal., Nutrition. 2010 Apr;26(4):441-8. Epub 2009 Oct 31. |
| 26. | Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling. | Fiory F, etal., Mol Cell Biol. 2005 Dec;25(24):10803-14. |
| 27. | Structural and functional studies of insulin receptors in human breast cancer. | Frittitta L, etal., Breast Cancer Res Treat. 1993;25(1):73-82. |
| 28. | Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats. | Gan KX, etal., World J Gastroenterol. 2013 Mar 14;19(10):1572-81. doi: 10.3748/wjg.v19.i10.1572. |
| 29. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 30. | Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. | Gerena Y, etal., PLoS One. 2012;7(5):e37358. doi: 10.1371/journal.pone.0037358. Epub 2012 May 22. |
| 31. | Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA. | Giddings SJ and Carnaghi LR, Mol Endocrinol. 1992 Oct;6(10):1665-72. doi: 10.1210/mend.6.10.1448116. |
| 32. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 33. | Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. | Grillo CA, etal., Physiol Behav. 2007 Nov 23;92(4):691-701. Epub 2007 May 21. |
| 34. | The effects of induced type-I diabetes on developmental regulation of insulin & insulin like growth factor-1 (IGF-1) receptors in the cerebellum of rat neonates. | Haghir H, etal., Metab Brain Dis. 2013 Sep;28(3):397-410. doi: 10.1007/s11011-013-9386-2. Epub 2013 Feb 10. |
| 35. | Sex differences and left-right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus. | Hami J, etal., Brain Struct Funct. 2012 Apr;217(2):293-302. doi: 10.1007/s00429-011-0358-1. Epub 2011 Nov 1. |
| 36. | The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus. | Hami J, etal., Brain Struct Funct. 2013 Jan;218(1):73-84. doi: 10.1007/s00429-011-0377-y. Epub 2012 Jan 13. |
| 37. | Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. | Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13. |
| 38. | Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. | Herold MJ, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18. |
| 39. | Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. | Hers I, etal., Biochem J 2002 Dec 15;368(Pt 3):875-84. |
| 40. | Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. | Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26. |
| 41. | Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. | Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81. |
| 42. | Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. | Hunter SJ and Garvey WT, Am J Med. 1998 Oct;105(4):331-45. |
| 43. | Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. | Irani BG, etal., Endocrinology. 2007 Jan;148(1):310-6. Epub 2006 Oct 5. |
| 44. | The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling. | Jacob AI, etal., J Mol Endocrinol. 2010 Mar;44(3):155-69. Epub 2009 Dec 1. |
| 45. | Identification of the rat adapter Grb14 as an inhibitor of insulin actions. | Kasus-Jacobi A, etal., J Biol Chem 1998 Oct 2;273(40):26026-35. |
| 46. | KEGG: Kyoto Encyclopedia of Genes and Genomes | KEGG |
| 47. | Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. | Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85. |
| 48. | Insulin receptor-overexpressing beta-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. | Kim MH, etal., PLoS One. 2013 Jul 9;8(7):e67802. doi: 10.1371/journal.pone.0067802. Print 2013. |
| 49. | Mosaic analysis of insulin receptor function. | Kitamura T, etal., J Clin Invest 2004 Jan;113(2):209-19. |
| 50. | Effects of dexamethasone on insulin receptor in aging. | Koricanac G, etal., Acta Biol Hung. 2008 Mar;59(1):17-29. |
| 51. | Insulin signaling in the liver and uterus of ovariectomized rats treated with estradiol. | Koricanac G, etal., J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):109-16. Epub 2007 Sep 7. |
| 52. | Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. | Kotnik K, etal., PLoS ONE. 2009;4(4):e5124. Epub 2009 Apr 2. |
| 53. | Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. | Kou ZZ, etal., Pain Physician. 2013 Mar-Apr;16(2):E71-83. |
| 54. | Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. | Lester-Coll N, etal., J Alzheimers Dis. 2006 Mar;9(1):13-33. |
| 55. | Insulin potentiates the proliferation and bone morphogenetic protein-2-induced osteogenic differentiation of rat spinal ligament cells via extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. | Li H, etal., Spine. 2008 Oct 15;33(22):2394-402. |
| 56. | Chronic ethanol consumption resulting in the downregulation of insulin receptor-beta subunit, insulin receptor substrate-1, and glucose transporter 4 expression in rat cardiac muscles. | Limin T, etal., Alcohol. 2009 Feb;43(1):51-8. |
| 57. | Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway. | Lin X, etal., Exp Ther Med. 2018 Jul;16(1):204-212. doi: 10.3892/etm.2018.6194. Epub 2018 May 18. |
| 58. | Insulin regulates P-glycoprotein in rat brain microvessel endothelial cells via an insulin receptor-mediated PKC/NF-kappaB pathway but not a PI3K/Akt pathway. | Liu H, etal., Eur J Pharmacol. 2009 Jan 14;602(2-3):277-82. Epub 2008 Nov 21. |
| 59. | Bidirectional regulation of upstream IGF-I/insulin receptor signaling and downstream FOXO1 in cardiomyocytes. | Liu TJ, etal., J Endocrinol. 2007 Jan;192(1):149-58. |
| 60. | The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-beta plaque and glial pathology in a mouse model of Alzheimer's disease. | Long-Smith CM, etal., Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21. |
| 61. | Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. | Lopez-Pastor AR, etal., Dis Model Mech. 2019 Feb 7;12(2). pii: dmm.036186. doi: 10.1242/dmm.036186. |
| 62. | SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates. | Maegawa H, etal., Biochem Biophys Res Commun. 1996 Nov 1;228(1):122-7. |
| 63. | Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways. | Mazibuko-Mbeje SE, etal., Int J Mol Sci. 2019 Feb 1;20(3). pii: ijms20030633. doi: 10.3390/ijms20030633. |
| 64. | The beta secretase BACE1 regulates the expression of insulin receptor in the liver. | Meakin PJ, etal., Nat Commun. 2018 Apr 3;9(1):1306. doi: 10.1038/s41467-018-03755-2. |
| 65. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 66. | Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. | Michael MD, etal., Mol Cell 2000 Jul;6(1):87-97. |
| 67. | Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death. | Mielke JG, etal., Neuroscience. 2006 Nov 17;143(1):165-73. Epub 2006 Sep 14. |
| 68. | Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. | Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub . |
| 69. | Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. | Mulligan AM, etal., Breast Cancer Res Treat. 2007 Nov;106(1):39-47. Epub 2007 Jan 13. |
| 70. | TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. | Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27. |
| 71. | Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice. | Murakami K, etal., Biochem Biophys Res Commun. 2011 May 27;409(1):34-9. doi: 10.1016/j.bbrc.2011.04.101. Epub 2011 Apr 28. |
| 72. | Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. | Murugan P, etal., J Biosci. 2008 Mar;33(1):63-72. |
| 73. | Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats. | Muthusamy T, etal., Life Sci. 2007 Jul 26;81(7):534-42. Epub 2007 Jun 28. |
| 74. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 75. | Differential expression of IGF components and insulin receptor isoforms in human seminoma versus normal testicular tissue. | Neuvians TP, etal., Neoplasia. 2005 May;7(5):446-56. |
| 76. | Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. | Obici S, etal., Nat Neurosci 2002 Jun;5(6):566-72. |
| 77. | Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. | Ofer P, etal., Mol Endocrinol. 2015 Dec;29(12):1694-707. doi: 10.1210/me.2015-1073. Epub 2015 Oct 9. |
| 78. | Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle. | Oh YS, etal., Exp Mol Med. 2007 Jun 30;39(3):395-401. |
| 79. | Transgenic rescue of insulin receptor-deficient mice. | Okamoto H, etal., J Clin Invest 2004 Jul;114(2):214-23. |
| 80. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 81. | Regulation of insulin receptor function by a small molecule insulin receptor activator. | Pender C, etal., J Biol Chem 2002 Nov 15;277(46):43565-71. |
| 82. | Apo A-1 mimetic peptide, L-4F prevents insulin resistance through increased HO-1 and pAMPK in obese mice. | Peterson SJ, etal., J Lipid Res. 2009 Mar 26. |
| 83. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 84. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 85. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 86. | Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima Fatty rats. | Qin B, etal., Atherosclerosis. 2012 Jun;222(2):409-16. doi: 10.1016/j.atherosclerosis.2012.03.033. Epub 2012 Apr 11. |
| 87. | GOA pipeline | RGD automated data pipeline |
| 88. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 89. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 90. | Insulin induces calcium signals in the nucleus of rat hepatocytes. | Rodrigues MA, etal., Hepatology. 2008 Nov;48(5):1621-31. |
| 91. | Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. | Samuel VT, etal., J Clin Invest. 2007 Mar;117(3):739-45. Epub 2007 Feb 22. |
| 92. | Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation. | Seki N, etal., Horm Metab Res. 2008 Dec;40(12):833-7. Epub 2008 Oct 16. |
| 93. | Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. | Sherajee SJ, etal., Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):257-63. doi: 10.1161/ATVBAHA.111.240697. Epub 2011 Dec 15. |
| 94. | Study of antidiabetic activity of a new ultralow-dose antibody preparation on the model of streptozotocin diabetes in rats. | Spasov AA, etal., Bull Exp Biol Med. 2007 Jul;144(1):46-8. |
| 95. | Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons. | Storozhevykh TP, etal., BMC Neurosci. 2007 Oct 8;8:84. |
| 96. | Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats. | Sugimoto K, etal., J Pain. 2008 Mar;9(3):237-45. Epub 2007 Dec 3. |
| 97. | Duodenal-jejunal bypass surgery up-regulates the expression of the hepatic insulin signaling proteins and the key regulatory enzymes of intestinal gluconeogenesis in diabetic Goto-Kakizaki rats. | Sun D, etal., Obes Surg. 2013 Nov;23(11):1734-42. doi: 10.1007/s11695-013-0985-0. |
| 98. | Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. | Szpirer C, etal., Mamm Genome 1997 Aug;8(8):586-8 |
| 99. | Altered expression of members of the IGF-axis in clear cell renal cell carcinoma. | Takahashi M, etal., Int J Oncol. 2005 Apr;26(4):923-31. |
| 100. | Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. | Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30. |
| 101. | Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. | Thyfault JP, etal., Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18. |
| 102. | Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. | Tiwari S, etal., J Am Soc Nephrol. 2007 Oct;18(10):2661-71. Epub 2007 Sep 12. |
| 103. | Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells. | Tornqvist HE, etal., J Biol Chem. 1988 Jan 5;263(1):350-9. |
| 104. | Effects of STZ-induced diabetes and fasting on insulin receptor mRNA expression and insulin receptor gene transcription in rat liver. | Tozzo E and Desbuquois B, Diabetes. 1992 Dec;41(12):1609-16. doi: 10.2337/diab.41.12.1609. |
| 105. | Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. | Venkateswaran V, etal., J Natl Cancer Inst. 2007 Dec 5;99(23):1793-800. Epub 2007 Nov 27. |
| 106. | Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway. | Wang Q, etal., Mol Med Rep. 2015 Jan;11(1):151-8. doi: 10.3892/mmr.2014.2762. Epub 2014 Oct 23. |
| 107. | Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor. | Wang X, etal., Mol Cell Endocrinol. 2015 Nov 15;416:57-69. doi: 10.1016/j.mce.2015.08.021. Epub 2015 Aug 20. |
| 108. | Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. | White MF, etal., J Biol Chem. 1984 Jan 10;259(1):255-64. |
| 109. | Resistin and insulin resistance in hepatocytes: Resistin disturbs glycogen metabolism at the protein level. | Yang Y, etal., Biomed Pharmacother. 2008 Jul 9. |
| 110. | [Effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides on non-alcoholic fatty liver disease induced by high-fat diet in mice]. | Yao FF, etal., Zhonghua Gan Zang Bing Za Zhi. 2017 Dec 20;25(12):927-933. doi: 10.3760/cma.j.issn.1007-3418.2017.12.008. |
| 111. | Regulation of insulin receptor function. | Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91. |
| 112. | Study on the mechanism of hepatocytic insulin signal transduction defects in severely scalded rats | Zhang B, etal., Zhonghua Shao Shang Za Zhi 2002 Aug;18(4):220-2. |
| 113. | Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity. | Zhang L, etal., J Transl Med. 2014 Aug 27;12:236. doi: 10.1186/s12967-014-0236-8. |
| 114. | Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. | Zhao WQ, etal., J Biol Chem. 2009 Jul 10;284(28):18742-53. doi: 10.1074/jbc.M109.011015. Epub 2009 Apr 30. |
| 115. | Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. | Zhou QG, etal., Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1154-65. doi: 10.1152/ajpheart.00407.2012. Epub 2012 Aug 31. |
Additional References at PubMed
| PMID:1520270 | PMID:1898103 | PMID:2210055 | PMID:2330003 | PMID:3518947 | PMID:6849137 | PMID:7493946 | PMID:7537849 | PMID:7556070 | PMID:7559478 | PMID:7693131 | PMID:8276809 |
| PMID:8440175 | PMID:8452530 | PMID:8496180 | PMID:9092559 | PMID:9415395 | PMID:9447983 | PMID:9819385 | PMID:9832615 | PMID:10100151 | PMID:10747347 | PMID:11500939 | PMID:11750072 |
| PMID:11939351 | PMID:12079879 | PMID:12101187 | PMID:12138094 | PMID:12477932 | PMID:12488434 | PMID:12821126 | PMID:12881524 | PMID:14506612 | PMID:14562105 | PMID:14628051 | PMID:14644152 |
| PMID:15069075 | PMID:15134438 | PMID:15134829 | PMID:15182363 | PMID:15337529 | PMID:15375597 | PMID:16052330 | PMID:16246733 | PMID:16353347 | PMID:16513830 | PMID:16803852 | PMID:16839253 |
| PMID:16921752 | PMID:16957736 | PMID:17001305 | PMID:17299086 | PMID:17555093 | PMID:17925406 | PMID:17974582 | PMID:18278056 | PMID:18313837 | PMID:18492485 | PMID:18679562 | PMID:18713797 |
| PMID:18752648 | PMID:19345745 | PMID:19386987 | PMID:19554259 | PMID:19575708 | PMID:19744960 | PMID:19953342 | PMID:20032056 | PMID:20100694 | PMID:20149705 | PMID:20443665 | PMID:20455999 |
| PMID:20458337 | PMID:20868513 | PMID:21195590 | PMID:21211393 | PMID:21301931 | PMID:21443795 | PMID:21683721 | PMID:21828334 | PMID:22207502 | PMID:22248283 | PMID:22564491 | PMID:22611938 |
| PMID:22871113 | PMID:22996137 | PMID:23059533 | PMID:23066017 | PMID:23300479 | PMID:23322319 | PMID:23382219 | PMID:23592917 | PMID:23839970 | PMID:23906066 | PMID:24023699 | PMID:24023717 |
| PMID:24078630 | PMID:24130215 | PMID:24462861 | PMID:24963636 | PMID:25401701 | PMID:26853939 | PMID:27930980 | PMID:28470423 | PMID:28495883 | PMID:29215540 | PMID:29289466 | PMID:29412813 |
| PMID:29955950 | PMID:33513940 | PMID:33915127 | PMID:34022289 | PMID:37566482 |
Genomics
Comparative Map Data
| Insr (Rattus norvegicus - Norway rat) |
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| INSR (Homo sapiens - human) |
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| Insr (Mus musculus - house mouse) |
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| Insr (Chinchilla lanigera - long-tailed chinchilla) |
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| INSR (Pan paniscus - bonobo/pygmy chimpanzee) |
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| INSR (Canis lupus familiaris - dog) |
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| Insr (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| INSR (Sus scrofa - pig) |
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| INSR (Chlorocebus sabaeus - green monkey) |
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| Insr (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Insr
661 total Variants 
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