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GENE - TERM ANNOTATION REPORT

10 Annotations Found.

An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from expression pattern (IEP)
    		•  
  • The annotation was made from Tiwari S, etal., J Am Soc Nephrol. 2007 Oct;18(10):2661-71. Epub 2007 Sep 12.
  • 5 additional annotations were made from Tiwari S, etal., J Am Soc Nephrol. 2007 Oct;18(10):2661-71. Epub 2007 Sep 12.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Curation Notes: protein:decreased expression:kidney


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27.
  • The annotation has been inferred from sequence orthology with Insr (Mus musculus) [(IDA) inferred from direct assay]
  • 5 additional annotations were made from Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Curation Notes: protein:increased serine phosphorylation, increased protein binding:liver


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Peterson SJ, etal., J Lipid Res. 2009 Mar 26.
  • The annotation has been inferred from sequence orthology with Insr (Mus musculus) [(IDA) inferred from direct assay]
  • 2 additional annotations were made from Peterson SJ, etal., J Lipid Res. 2009 Mar 26.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Qualifier: treatment


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from direct assay (IDA)
    		•  
  • The annotation was made from Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27.
  • 5 additional annotations were made from Munoz MC, etal., J Endocrinol. 2009 May;201(2):185-97. Epub 2009 Feb 27.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Qualifier: treatment


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Kotnik K, etal., PLoS ONE. 2009;4(4):e5124. Epub 2009 Apr 2.
  • 13 additional annotations were made from Kotnik K, etal., PLoS ONE. 2009;4(4):e5124. Epub 2009 Apr 2.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from direct assay (IDA)
    		•  
  • The annotation was made from Thyfault JP, etal., Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18.
  • 2 additional annotations were made from Thyfault JP, etal., Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39. Epub 2006 Oct 18.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.
  • The annotation has been inferred from sequence orthology with INSR (Homo sapiens) [(IDA) inferred from direct assay]
  • 5 additional annotations were made from Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Curation Notes: protein:decreased phosphorylation:vastus lateralis:phosphotyrosine (human)


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from Herold MJ, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18.
  • 12 additional annotations were made from Herold MJ, etal., Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from direct assay (IDA)
    		•  
  • The annotation was made from Sun D, etal., Obes Surg. 2013 Nov;23(11):1734-42. doi: 10.1007/s11695-013-0985-0.
  • 2 additional annotations were made from Sun D, etal., Obes Surg. 2013 Nov;23(11):1734-42. doi: 10.1007/s11695-013-0985-0.
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Qualifier: treatment


    • An association has been curated linking Insr and type 2 diabetes mellitus in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with INSR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 808 RGD objects have been annotated to type 2 diabetes mellitus  (DOID:9352)
  • 115 papers in RGD have been used to annotate Insr
  • Curation Notes: ClinVar Annotator: match by term: Insulin-resistant diabetes mellitus | ClinVar Annotator: match by term: Type 2 diabetes mellitus
  • Original References(s): PMID:10084586 PMID:11463381 PMID:1607076 PMID:1845971 PMID:2040394 PMID:25741868 PMID:27896077 PMID:28492532 PMID:2884728 PMID:31989990 PMID:4413914 PMID:7814014 PMID:8432414 PMID:8900242


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