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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrincreases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of INSR proteinPMID:18426865
Insrmultiple interactionsEXP 6480464CTDESR1 protein promotes the reaction [resveratrol results in increased phosphorylation of INSR protein]; fulvestrant inhibits the reaction [resveratrol results in increased phosphorylation of INSR protein]; resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of INSR protein]PMID:18426865 PMID:25352008
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTDresveratrol binds to and results in decreased phosphorylation of and results in decreased activity of INSR proteinPMID:22935344
Insrmultiple interactionsISOINSR (Homo sapiens)6480464CTDresveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; resveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]PMID:22917016 PMID:25808216
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