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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insraffects methylationISOINSR (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of INSR 3' UTR; Benzo(a)pyrene affects the methylation of INSR intronPMID:27901495 PMID:30157460
Insrdecreases expressionISOInsr (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of INSR mRNAPMID:15894712
Insrdecreases expressionISOINSR (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of INSR mRNAPMID:17879257 PMID:32234424
Insrincreases mutagenesisISOINSR (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of INSR genePMID:25435355
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of INSR mRNAPMID:15894712
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