Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrmultiple interactionsEXP 6480464CTD3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; Catechin inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; Glucose results in decreased expression of and results in decreased phosphorylation of INSR proteinPMID:29981789
Insrdecreases degradationISOINSR (Homo sapiens)6480464CTDGlucose results in decreased degradation of INSR mRNAPMID:7826318
Insrdecreases expressionISOINSR (Homo sapiens)6480464CTDGlucose results in decreased expression of INSR protein; Glucose results in decreased expression of INSR protein modified formPMID:24262486
Insrincreases expressionISOINSR (Homo sapiens)6480464CTDGlucose results in increased expression of INSR mRNAPMID:7826318
Insrincreases phosphorylationISOINSR (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of INSR proteinPMID:7826318
Insrmultiple interactionsISOINSR (Homo sapiens)6480464CTDCatechin inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]; Catechin inhibits the reaction [Glucose results in decreased expression of INSR protein]; Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; PARP1 protein affects the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein]PMID:21031461 PMID:24262486
Go Back to source page   Continue to Ontology report