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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of INSR mRNA; bisphenol A results in decreased expression of INSR proteinPMID:22142692 PMID:23424204 PMID:30816183 PMID:31551937 PMID:32145629 PMID:32528016
Insrdecreases phosphorylationEXP 6480464CTDbisphenol A results in decreased phosphorylation of INSR proteinPMID:25112833
Insrincreases expressionEXP 6480464CTDbisphenol A results in increased expression of INSR proteinPMID:27836638
Insrincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of INSR genePMID:28505145
Insrmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of INSR mRNA; bisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]; bisphenol A results in decreased expression of and results in decreased phosphorylation of INSR protein; Dietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of INSR protein]PMID:25112833 PMID:28153594 PMID:28739533 PMID:36041667
Insrdecreases expressionISOInsr (Mus musculus)6480464CTDbisphenol A results in decreased expression of INSR mRNA; bisphenol A results in decreased expression of INSR proteinPMID:23376180 PMID:26779933 PMID:35489422 PMID:37894381
Insrdecreases expressionISOINSR (Homo sapiens)6480464CTDbisphenol A results in decreased expression of INSR protein; bisphenol A results in decreased expression of INSR protein modified formPMID:29793316 PMID:33376534
Insrdecreases methylationISOINSR (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of INSR genePMID:31601247
Insrdecreases phosphorylationISOInsr (Mus musculus)6480464CTDbisphenol A results in decreased phosphorylation of INSR proteinPMID:25637671 PMID:26779933
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNAPMID:28433925
Insrmultiple interactionsISOINSR (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]PMID:24349194 PMID:29793316
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