GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Insr | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of INSR mRNA; bisphenol A results in decreased expression of INSR protein | PMID:22142692 PMID:23424204 PMID:30816183 PMID:31551937 PMID:32145629 PMID:32528016 | Insr | decreases phosphorylation | EXP | | 6480464 | CTD | bisphenol A results in decreased phosphorylation of INSR protein | PMID:25112833 | Insr | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of INSR protein | PMID:27836638 | Insr | increases methylation | EXP | | 6480464 | CTD | bisphenol A results in increased methylation of INSR gene | PMID:28505145 | Insr | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of INSR mRNA; bisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]; bisphenol A results in decreased expression of and results in decreased phosphorylation of INSR protein; Dietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of INSR protein] | PMID:25112833 PMID:28153594 PMID:28739533 PMID:36041667 | Insr | decreases expression | ISO | Insr (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased expression of INSR mRNA; bisphenol A results in decreased expression of INSR protein | PMID:23376180 PMID:26779933 PMID:35489422 PMID:37894381 | Insr | decreases expression | ISO | INSR (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of INSR protein; bisphenol A results in decreased expression of INSR protein modified form | PMID:29793316 PMID:33376534 | Insr | decreases methylation | ISO | INSR (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of INSR gene | PMID:31601247 | Insr | decreases phosphorylation | ISO | Insr (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased phosphorylation of INSR protein | PMID:25637671 PMID:26779933 | Insr | multiple interactions | ISO | Insr (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA | PMID:28433925 | Insr | multiple interactions | ISO | INSR (Homo sapiens) | 6480464 | CTD | bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form] | PMID:24349194 PMID:29793316 | |
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