RGD Reference Report - Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet.

Authors: Barbuio, R  Milanski, M  Bertolo, MB  Saad, MJ  Velloso, LA 
Citation: Barbuio R, etal., J Endocrinol. 2007 Sep;194(3):539-50.
RGD ID: 2307032
Pubmed: PMID:17761893   (View Abstract at PubMed)
DOI: DOI:10.1677/JOE-07-0234   (Journal Full-text)

Non-alcoholic fatty liver disease, induced by nutritional factors, is one of the leading causes of hepatic dysfunction in the modern world. The activation of proinflammatory signaling in the liver, which is induced by systemic and locally produced cytokines, and the development of hepatic insulin resistance are two important factors associated with the progression from steatosis to steatohepatitis, a pre-cirrhotic condition. The objective of the present study was to evaluate the effect of inhibition of tumour necrosis factor (TNF)-alpha , using the monoclonal antibody infliximab, on the expression of cytokines, induction of steatosis and fibrosis, and insulin signal transduction in the liver of Wistar rats fed a high-fat diet. Ten days of treatment with infliximab significantly reduced the expression of the proinflammatory markers, TNF-alpha , IL-6, IL-1beta , and SOCS-3, in the liver of rats fed a high-fat diet. This was accompanied by reduced fat deposition and fibrosis and by improved insulin signal transduction through insulin receptor (IR)/IR substrate/Akt/FOXO1 and JAK2/STAT3 pathways. In conclusion, short-term inhibition of TNF-alpha with infliximab reduces inflammation and steatosis/fibrosis, while improving insulin signal transduction in an animal model treated with a high-fat diet.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to tumor necrosis factor  IMP 2307032 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Insr  (insulin receptor)


Additional Information