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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrdecreases expressionEXP 6480464CTDFructose results in decreased expression of INSR mRNA; Fructose results in decreased expression of INSR proteinPMID:14573337
Insrdecreases phosphorylationEXP 6480464CTDFructose results in decreased phosphorylation of INSR proteinPMID:22426011 PMID:24491314
Insrmultiple interactionsEXP 6480464CTD[Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNA; [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR protein; Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]PMID:14633139 PMID:22426011 PMID:24491314 PMID:24704288
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