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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insraffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of INSR mRNAPMID:15977195
Insrincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of INSR mRNAPMID:32109520
Insrmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of INSR mRNAPMID:15977195
Insrdecreases expressionISOInsr (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of INSR mRNA; Tetrachlorodibenzodioxin results in decreased expression of INSR proteinPMID:20181658
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR mRNA]; MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; TNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]PMID:20181658 PMID:28433925
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