GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Insr | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of INSR mRNA | PMID:15977195 | Insr | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of INSR mRNA | PMID:32109520 | Insr | multiple interactions | EXP | | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of INSR mRNA | PMID:15977195 | Insr | decreases expression | ISO | Insr (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of INSR mRNA; Tetrachlorodibenzodioxin results in decreased expression of INSR protein | PMID:20181658 | Insr | multiple interactions | ISO | Insr (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of INSR mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR mRNA]; MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; TNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]; U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein] | PMID:20181658 PMID:28433925 | |
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