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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrincreases expression EXP 15036814RGDstreptozocin increases expression of hepatic mRNA 
Insraffects expressionEXP 6480464CTDStreptozocin affects the expression of INSR proteinPMID:17068109
Insrdecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of INSR mRNA; Streptozocin results in decreased expression of INSR proteinPMID:19705549 PMID:23562514 PMID:32805344
Insrdecreases phosphorylationEXP 6480464CTDStreptozocin results in decreased phosphorylation of INSR proteinPMID:18331706
Insrincreases expressionEXP 6480464CTDStreptozocin results in increased expression of INSR mRNAPMID:9243097
Insrmultiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein; [Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of INSR protein; Estradiol affects the reaction [Streptozocin affects the expression of INSR protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INSR protein]; Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein]; Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR protein]; Progesterone affects the reaction [Streptozocin affects the expression of INSR protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INSR protein]; Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]]; xanthoceraside inhibits the reaction [Streptozocin results in decreased expression of INSR protein]PMID:17068109 PMID:19705549 PMID:21439094 PMID:23562514 PMID:29614383 PMID:32805344 PMID:36547818 PMID:37566541
Insrdecreases expressionISOInsr (Mus musculus)6480464CTDStreptozocin results in decreased expression of INSR mRNAPMID:23927877
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTD[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein; [Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of INSR protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]PMID:23927877 PMID:25446853 PMID:26522834 PMID:33359794
Insrmultiple interactionsISOINSR (Homo sapiens)6480464CTDresveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]PMID:25808216
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