GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Insr | increases expression | EXP | | 15036814 | RGD | streptozocin increases expression of hepatic mRNA | | Insr | affects expression | EXP | | 6480464 | CTD | Streptozocin affects the expression of INSR protein | PMID:17068109 | Insr | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of INSR mRNA; Streptozocin results in decreased expression of INSR protein | PMID:19705549 PMID:23562514 PMID:32805344 | Insr | decreases phosphorylation | EXP | | 6480464 | CTD | Streptozocin results in decreased phosphorylation of INSR protein | PMID:18331706 | Insr | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of INSR mRNA | PMID:9243097 | Insr | multiple interactions | EXP | | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein; [Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of INSR protein; Estradiol affects the reaction [Streptozocin affects the expression of INSR protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INSR protein]; Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein]; Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR protein]; Progesterone affects the reaction [Streptozocin affects the expression of INSR protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INSR protein]; Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]]; xanthoceraside inhibits the reaction [Streptozocin results in decreased expression of INSR protein] | PMID:17068109 PMID:19705549 PMID:21439094 PMID:23562514 PMID:29614383 PMID:32805344 PMID:36547818 PMID:37566541 | Insr | decreases expression | ISO | Insr (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased expression of INSR mRNA | PMID:23927877 | Insr | multiple interactions | ISO | Insr (Mus musculus) | 6480464 | CTD | [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein; [Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of INSR protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] | PMID:23927877 PMID:25446853 PMID:26522834 PMID:33359794 | Insr | multiple interactions | ISO | INSR (Homo sapiens) | 6480464 | CTD | resveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein] | PMID:25808216 | |
Go Back to source page | Continue to Ontology report |