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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insraffects expressionEXP 6480464CTDZinc affects the expression of INSR mRNAPMID:16413754
Insrdecreases expressionEXP 6480464CTDZinc deficiency results in decreased expression of INSR mRNA; Zinc deficiency results in decreased expression of INSR proteinPMID:21893222
Insrmultiple interactionsEXP 6480464CTD[Zinc co-treated with INS1 protein] results in increased phosphorylation of INSR proteinPMID:1321133
Insrincreases phosphorylationISOInsr (Mus musculus)6480464CTDZinc results in increased phosphorylation of INSR proteinPMID:15516700
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTDChromium promotes the reaction [Zinc results in increased phosphorylation of INSR protein]; Zinc promotes the reaction [Chromium results in increased phosphorylation of INSR protein]PMID:15516700
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