GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Insr | multiple interactions | EXP | | 6480464 | CTD | Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein] | PMID:36547818 | Insr | increases phosphorylation | ISO | INSR (Homo sapiens) | 6480464 | CTD | Metformin results in increased phosphorylation of INSR protein | PMID:26835874 | Insr | multiple interactions | ISO | Insr (Mus musculus) | 6480464 | CTD | Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] | PMID:23927877 | Insr | multiple interactions | ISO | INSR (Homo sapiens) | 6480464 | CTD | [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA | PMID:21664031 | |
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