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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrmultiple interactionsEXP 6480464CTDMetformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein]PMID:36547818
Insrincreases phosphorylationISOINSR (Homo sapiens)6480464CTDMetformin results in increased phosphorylation of INSR proteinPMID:26835874
Insrmultiple interactionsISOInsr (Mus musculus)6480464CTDMetformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]PMID:23927877
Insrmultiple interactionsISOINSR (Homo sapiens)6480464CTD[Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNAPMID:21664031
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