RGD Reference Report - Effects of dexamethasone on insulin receptor in aging. - Rat Genome Database

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Effects of dexamethasone on insulin receptor in aging.

Authors: Koricanac, G  Stojiljkovic, M  Radivojsa, S  Zakula, Z  Ribarac-Stepic, N  Isenovic, ER 
Citation: Koricanac G, etal., Acta Biol Hung. 2008 Mar;59(1):17-29.
RGD ID: 2307026
Pubmed: PMID:18401942   (View Abstract at PubMed)
DOI: DOI:10.1556/ABiol.59.2008.1.2   (Journal Full-text)

The aim of this study was to examine the effects of dexamethasone (Dex) on functional properties of the rat insulin receptor (IR). Male Mill Hill hooded rats, 3, 6, 12, 18 and 21 months old, were injected with Dex (4 mg/kg) and rat liver and erythrocytes were used for experiments 18 h after Dex administration. Treatment with Dex lowered the specific binding (SB) of insulin (INS) in the liver of 3- and 18-month-old rats and concentration of INS binding sites (N1, N2) and the dissociation constant of low-affinity binding sites (Kd2) in the liver of 6- and 18-month-old rats. In addition, Dex treatment lowered the liver IR protein level in all analyzed groups, except 21-month-old rats where it remained unchanged, but raised the IR mRNA level in 18-month-old rats. In erythrocytes, treatment with Dex decreased SB and Kd2 (in animals 3 and 6 months old) and N1 (in ones 3 and 18 months old). Following Dex treatment, the INS plasma level increased (in rats 3, 18 and 21 months old), while glucose (Glu) concentration increased in 3 and 12 months old, but decreased in 6- and 21-month-old rats. In summary, Dex exerts the strongest effect on the erythrocyte IR of 3- and 6-month-old rats and the hepatic IR of 18-month-old rats. IR in both tissues is almost insensitive to Dex in 12- and 21-month-old rats. The pattern of age-related changes of IR induced by Dex does not correlate with changes of plasma Glu and INS.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to glucocorticoid  IEP 2307026DexamethasoneRGD 

Objects Annotated

Genes (Rattus norvegicus)
Insr  (insulin receptor)


Additional Information