cis-caffeic acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	cis-caffeic acid	go back to main search page
Accession:	CHEBI:17395	browse the term
Definition:	The cis-isomer of caffeic acid.
Synonyms:	exact_synonym:	(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
	related_synonym:	3,4-Dihydroxycinnamic acid; Caffeate; Caffeic acid; Formula=C9H8O4; InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2-; InChIKey=QAIPRVGONGVQAS-RQOWECAXSA-N; SMILES=OC(=O)\\C=C/c1ccc(O)c(O)c1
	alt_id:	CHEBI:13929; CHEBI:19880; CHEBI:19881; CHEBI:22979; CHEBI:3292
	xref:	CAS:331-39-5; DrugBank:DB01880; HMDB:HMDB0001964; KEGG:C01481
	xref_mesh:	MESH:C040048
	xref:	MetaCyc:CPD-8098; PMID:19812218; PMID:19952409; PMID:24088646; PMID:24138287; PMID:24206679; Reaxys:2210884
	cyclic_relationship:	is_conjugate_acid_of CHEBI:58129

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Genes (119)

cis-caffeic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetylcholinesterase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

arachidonate 15-lipoxygenase

multiple interactions
decreases activity

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]

PMID:10904086 PMID:11406566 PMID:15574791

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

arachidonate 5-lipoxygenase

multiple interactions

caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]
caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]

PMID:18482095 PMID:18951527 PMID:27368151

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

amyloid beta precursor protein

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

arginase 1

decreases activity

caffeic acid results in decreased activity of ARG1 protein

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ATPase H+ transporting V0 subunit D2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

caspase 3

multiple interactions

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]

PMID:15574791 PMID:29968957

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
increases activity

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein

PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:16806235 PMID:31306686

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine receptor 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

Cd4 molecule

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA

NCBI chr 4:157,668,878...157,695,366

G

Cd68 molecule

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

cell division cycle 20

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cyclin dependent kinase 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

choline O-acetyltransferase

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of caffeic acid

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

corticotropin releasing hormone

multiple interactions

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cardiotrophin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

cathepsin B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

death-associated protein

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

dihydropyrimidinase-like 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

endothelin 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

early growth response 1

multiple interactions

caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

engulfment and cell motility 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]

NCBI chr 3:154,023,661...154,061,259
Ensembl chr 3:154,023,661...154,061,185

G

Ets2 repressor factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]

NCBI chr 1:80,829,935...80,838,388
Ensembl chr 1:80,829,935...80,838,388

G

coagulation factor III, tissue factor

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid synthase

decreases expression
multiple interactions

caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein

PMID:21870829 PMID:28576465

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibronectin leucine rich transmembrane protein 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]

NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785

G

Fms related receptor tyrosine kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]

NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770

G

glucose-6-phosphate dehydrogenase

decreases activity

caffeic acid results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein]

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

galactosidase, beta 1

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glutaminase

increases expression

caffeic acid results in increased expression of GLS protein

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

glutamic-oxaloacetic transaminase 1

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:15212457 PMID:27720869

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]

PMID:19442820 PMID:21640567 PMID:22036979

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

decreases activity

caffeic acid results in decreased activity of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases activity

caffeic acid results in decreased activity of GSTM2 protein

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

decreases activity

caffeic acid results in decreased activity of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glucuronidase, beta

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein]

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hepatitis A virus cellular receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA

NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137

G

hes family bHLH transcription factor 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

holocarboxylase synthetase

decreases activity

caffeic acid results in decreased activity of HLCS protein

NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

caffeic acid results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heat shock protein 90 beta family member 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family E (Hsp10) member 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA]

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

interferon gamma

increases expression
multiple interactions

caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]

PMID:27378625 PMID:29968957

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

decreases expression

caffeic acid results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]

PMID:27368151 PMID:27720869

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

caffeic acid results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 21 receptor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA]

NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522

G

interleukin 4

decreases expression

caffeic acid results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
multiple interactions

caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]

PMID:21870829 PMID:27368151 PMID:27720869

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kinesin family member 15

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 20B

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA]

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 2C

multiple interactions

caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA]

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

G

lactate dehydrogenase A

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

monoamine oxidase A

decreases activity

caffeic acid results in decreased activity of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases activity

caffeic acid results in decreased activity of MAOB protein

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 5

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen activated protein kinase 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitofusin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

microsomal glutathione S-transferase 1

increases activity

caffeic acid results in increased activity of MGST1 protein

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myeloperoxidase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid results in decreased activity of MPO protein
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]

PMID:22036979 PMID:24060682 PMID:33301711

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein L45

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA]

NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474

G

mitochondrial ribosome recycling factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA]

NCBI chr 3:19,487,124...19,543,911
Ensembl chr 3:19,487,182...19,543,908

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

[caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

norrin cystine knot growth factor NDP

increases expression

caffeic acid results in increased expression of NDP mRNA

NCBI chr X:5,796,487...5,820,934
Ensembl chr X:5,796,487...5,820,934

G

nitric oxide synthase 2

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:29968957 PMID:31306686

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression

caffeic acid results in increased expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA]

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

5' nucleotidase, ecto

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

programmed cell death 10

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA]

NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018

G

phosphogluconate dehydrogenase

decreases activity

caffeic acid results in decreased activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

caffeic acid results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

polo-like kinase 1

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

peroxisome proliferator-activated receptor gamma

increases expression

caffeic acid results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peroxiredoxin 5

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

prostaglandin-endoperoxide synthase 2

multiple interactions

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]

PMID:19442820 PMID:22036979 PMID:31306686

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

pentraxin 3

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

stearoyl-CoA desaturase

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

serpin family E member 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sideroflexin 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA]

NCBI chr 1:259,976,480...259,998,778
Ensembl chr 1:259,976,481...259,998,754

G

solute carrier family 2 member 2

increases expression

caffeic acid results in increased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

increases expression

caffeic acid results in increased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 5 member 1

increases expression

caffeic acid results in increased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

synuclein alpha

multiple interactions

caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

serine/threonine kinase 32A

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA

NCBI chr18:35,258,865...35,374,985
Ensembl chr18:35,259,052...35,369,451

G

sulfotransferase family 1A member 1

increases sulfation

SULT1A1 protein results in increased sulfation of caffeic acid

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1C member 2A

increases sulfation

SULT1C2 protein results in increased sulfation of caffeic acid

NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734

G

tumor necrosis factor

increases expression
multiple interactions

caffeic acid results in increased expression of TNF mRNA
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]

PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

affects expression
multiple interactions

caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]

PMID:11522280 PMID:19442820

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin-conjugating enzyme E2C

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA]

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

UDP glucuronosyltransferase family 1 member A1

decreases activity

caffeic acid results in decreased activity of UGT1A1 protein

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

UGT1A3 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

decreases activity

caffeic acid results in decreased activity of UGT1A6 protein

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

decreases activity

caffeic acid results in decreased activity of UGT1A9 protein

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

caffeic acid results in decreased activity of UGT2B17 protein

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

decreases activity

caffeic acid results in decreased activity of UGT2B7 protein

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

vascular endothelial growth factor A

decreases secretion

caffeic acid results in decreased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

xanthine dehydrogenase

multiple interactions

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19834
role	19810
chemical role	19445
antioxidant	16147
caffeic acid	596
cis-caffeic acid	119
(2S,3R)-cis-caftaric acid	0
3-(Z)-caffeoyllupeol	0
5-O-cis-caffeoylquinic acid	0
malvidin 3-O-\	0
Path 2
Term	Annotations
CHEBI ontology	19834
subatomic particle	19832
composite particle	19832
hadron	19832
baryon	19832
nucleon	19832
atomic nucleus	19832
atom	19832
main group element atom	19782
p-block element atom	19782
carbon group element atom	19731
carbon atom	19727
organic molecular entity	19727
heteroorganic entity	19484
organochalcogen compound	19248
organooxygen compound	19165
carbon oxoacid	18633
carboxylic acid	18630
monocarboxylic acid	18005
alpha,beta-unsaturated monocarboxylic acid	13459
cinnamic acids	2509
hydroxycinnamic acid	1364
caffeic acid	596
cis-caffeic acid	119
(2S,3R)-cis-caftaric acid	0
3-(Z)-caffeoyllupeol	0
5-O-cis-caffeoylquinic acid	0
malvidin 3-O-\	0

paths to the root