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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | RGD:732280 | 6480464 | [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA | CTD | PMID:16806235 | (R)-mevalonic acid | multiple interactions | ISO | RGD:1349625 | 6480464 | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] | CTD | PMID:16321392 | 1-chloro-2,4-dinitrobenzene | increases expression | ISO | RGD:732280 | 6480464 | Dinitrochlorobenzene results in increased expression of CCR1 mRNA | CTD | PMID:19647056 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1349625 | 6480464 | [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR1 protein | CTD | PMID:10770211 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of CCR1 mRNA | CTD | PMID:15212814 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:732280 | 6480464 | Ethinyl Estradiol results in decreased expression of CCR1 mRNA | CTD | PMID:15885639 | 3,3',4,4'-tetrachlorobiphenyl | affects expression | ISO | RGD:1349625 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl affects the expression of CCR1 mRNA | CTD | PMID:20638727 | 4-(ethoxymethylene)-2-phenyloxazol-5-one | increases expression | ISO | RGD:732280 | 6480464 | Oxazolone results in increased expression of CCR1 mRNA | CTD | PMID:19647056 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:732280 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA | CTD | PMID:19191707 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1349625 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA | CTD | PMID:12419474 | all-trans-retinoic acid | increases expression | ISO | RGD:1349625 | 6480464 | Tretinoin results in increased expression of CCR1 mRNA | CTD | PMID:19828696 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1349625 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in increased expression of CCR1 mRNA | CTD | PMID:15894607 | all-trans-retinoic acid | increases expression | ISO | RGD:1349625 | 6480464 | Tretinoin results in increased expression of CCR1 mRNA | CTD | PMID:15498508 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:1349625 | 6480464 | Tretinoin results in increased expression of CCR1 mRNA | CTD | PMID:15498508 PMID:19828696 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CCR1 mRNA | CTD | PMID:16483693 | arsenic atom | multiple interactions | ISO | RGD:1349625 | 6480464 | [Arsenic co-treated with Fluorides] results in decreased expression of CCR1 mRNA | CTD | PMID:19962721 | arsenic atom | decreases expression | ISO | RGD:732280 | 6480464 | Arsenic results in decreased expression of CCR1 mRNA | CTD | PMID:19654921 | arsenic atom | decreases expression | ISO | RGD:1349625 | 6480464 | Arsenic results in decreased expression of CCR1 mRNA | CTD | PMID:19962721 | arsenite(3-) | decreases expression | ISO | RGD:732280 | 6480464 | arsenite results in decreased expression of CCR1 mRNA | CTD | PMID:18191166 | benzo[a]pyrene | multiple interactions | ISO | RGD:732280 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of CCR1 mRNA | CTD | PMID:21715664 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:732280 | 6480464 | Mustard Gas results in increased expression of CCR1 mRNA | CTD | PMID:15674843 PMID:18955075 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:732280 | 6480464 | Mustard Gas results in increased expression of CCR1 mRNA | CTD | PMID:18955075 PMID:15674843 | cadmium dichloride | increases expression | ISO | RGD:1349625 | 6480464 | Cadmium Chloride results in increased expression of CCR1 mRNA | CTD | PMID:12160620 | carbofuran | increases expression | EXP | | 6480464 | Carbofuran results in increased expression of CCR1 mRNA | CTD | PMID:20211217 | cis-caffeic acid | multiple interactions | ISO | RGD:732280 | 6480464 | [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA | CTD | PMID:16806235 | cisplatin | increases expression | ISO | RGD:732280 | 6480464 | Cisplatin results in increased expression of CCR1 mRNA | CTD | PMID:15814532 | cisplatin | multiple interactions | ISO | RGD:732280 | 6480464 | pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR1 mRNA] | CTD | PMID:15814532 | cyproterone acetate | multiple interactions | ISO | RGD:1349625 | 6480464 | [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR1 protein | CTD | PMID:10770211 | diarsenic trioxide | multiple interactions | ISO | RGD:1349625 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in increased expression of CCR1 mRNA | CTD | PMID:15894607 | diazoxide | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of CCR1 mRNA | CTD | PMID:20211217 | dioxygen | multiple interactions | ISO | RGD:732280 | 6480464 | HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CCR1 mRNA] | CTD | PMID:20880076 | dioxygen | increases expression | ISO | RGD:732280 | 6480464 | Oxygen deficiency results in increased expression of CCR1 mRNA | CTD | PMID:20880076 | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of CCR1 mRNA | CTD | PMID:20211217 | hydrogen peroxide | decreases expression | ISO | RGD:1349625 | 6480464 | Hydrogen Peroxide results in decreased expression of CCR1 mRNA | CTD | PMID:12419474 | isoprenaline | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of CCR1 mRNA | CTD | PMID:20211217 | mevalonic acid | multiple interactions | ISO | RGD:1349625 | 6480464 | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] | CTD | PMID:16321392 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:732280 | 6480464 | CCR1 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 mRNA]; more ... | CTD | PMID:16284949 | nickel sulfate | affects expression | ISO | RGD:1349625 | 6480464 | nickel sulfate affects the expression of CCR1 mRNA | CTD | PMID:18202158 | paracetamol | affects expression | ISO | RGD:732280 | 6480464 | Acetaminophen affects the expression of CCR1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:1349625 | 6480464 | Acetaminophen results in decreased expression of CCR1 mRNA | CTD | PMID:21420995 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CCR1 mRNA | CTD | PMID:19784758 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CCR1 mRNA | CTD | PMID:19784758 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of CCR1 mRNA | CTD | PMID:19784758 | pirinixic acid | multiple interactions | ISO | RGD:732280 | 6480464 | pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR1 mRNA] | CTD | PMID:15814532 | pirinixic acid | increases expression | ISO | RGD:732280 | 6480464 | pirinixic acid results in increased expression of CCR1 mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:732280 | 6480464 | pirinixic acid results in decreased expression of CCR1 mRNA | CTD | PMID:16985257 | resveratrol | multiple interactions | ISO | RGD:732280 | 6480464 | [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA | CTD | PMID:16806235 | silicon dioxide | increases expression | ISO | RGD:732280 | 6480464 | Silicon Dioxide results in increased expression of CCR1 mRNA | CTD | PMID:19073995 | simvastatin | multiple interactions | ISO | RGD:1349625 | 6480464 | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] | CTD | PMID:16321392 | simvastatin | decreases expression | EXP | | 6480464 | Simvastatin results in decreased expression of CCR1 mRNA | CTD | PMID:16414398 | sterigmatocystin | increases expression | ISO | RGD:732280 | 6480464 | Sterigmatocystin results in increased expression of CCR1 mRNA | CTD | PMID:19818335 | styrene | decreases expression | ISO | RGD:1349625 | 6480464 | Styrene results in decreased expression of CCR1 mRNA; more ... | CTD | PMID:15212811 | succimer | multiple interactions | ISO | RGD:732280 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCR1 mRNA | CTD | PMID:21641980 | tamibarotene | increases expression | ISO | RGD:1349625 | 6480464 | Am 80 results in increased expression of CCR1 mRNA; more ... | CTD | PMID:15498508 | testosterone enanthate | affects expression | ISO | RGD:1349625 | 6480464 | testosterone enanthate affects the expression of CCR1 mRNA | CTD | PMID:17440010 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CCR1 mRNA | CTD | PMID:19784758 | tetrachloromethane | increases expression | ISO | RGD:732280 | 6480464 | Carbon Tetrachloride results in increased expression of CCR1 mRNA | CTD | PMID:23288052 | tetradecane | decreases expression | EXP | | 6480464 | n-tetradecane results in decreased expression of CCR1 protein | CTD | PMID:17337753 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of CCR1 mRNA | CTD | PMID:19784758 | trans-resveratrol | multiple interactions | ISO | RGD:732280 | 6480464 | [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA | CTD | PMID:16806235 | trimellitic anhydride | increases expression | ISO | RGD:732280 | 6480464 | trimellitic anhydride results in increased expression of CCR1 mRNA | CTD | PMID:16141432 | valproic acid | affects expression | ISO | RGD:732280 | 6480464 | Valproic Acid affects the expression of CCR1 mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
References - curated| 1. |
Adamus G, etal., Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2894-903. |
| 2. |
Ajuebor MN, etal., Eur J Immunol. 2004 Oct;34(10):2907-18. |
| 3. |
Amat M, etal., Br J Pharmacol. 2006 Nov;149(6):666-75. Epub 2006 Oct 3. |
| 4. |
Anders HJ, etal., J Am Soc Nephrol. 2004 Jun;15(6):1504-13. |
| 5. |
Bonville CA, etal., J Virol. 2004 Aug;78(15):7984-9. |
| 6. |
Booth G, etal., Autoimmunity. 2008 Nov;41(7):512-21. |
| 7. |
Borregaard J, etal., Contact Dermatitis. 2008 Oct;59(4):212-9. |
| 8. |
Carpenter KJ, etal., Br J Pharmacol. 2005 Aug;145(8):1160-72. |
| 9. |
Choi SW, etal., Blood. 2007 Nov 1;110(9):3447-55. Epub 2007 Jul 19. |
| 10. |
Cowell RM and Silverstein FS, J Comp Neurol. 2003 Feb 24;457(1):7-23. |
| 11. |
Di Marzio P, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):909-16. |
| 12. |
Eltayeb S, etal., J Neuroimmunol. 2003 Sep;142(1-2):75-85. |
| 13. |
Estep JM, etal., Obes Surg. 2009 May;19(5):617-24. Epub 2009 Mar 12. |
| 14. |
Gladue RP, etal., J Immunol. 2006 Mar 1;176(5):3141-8. |
| 15. |
Halks-Miller M, etal., Ann Neurol. 2003 Nov;54(5):638-46. |
| 16. |
Haringman JJ, etal., Ann Rheum Dis. 2003 Aug;62(8):715-21. |
| 17. |
Havaux X, etal., Clin Exp Immunol. 2005 Feb;139(2):179-88. |
| 18. |
He M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1173-80. Epub 2007 Jan 18. |
| 19. |
He M, etal., Pancreas. 2007 Mar;34(2):233-41. |
| 20. |
Hickey MJ, etal., Viral Immunol. 2007 Dec;20(4):599-608. |
| 21. |
Ji J, etal., Infect Immun. 2003 Aug;71(8):4278-88. |
| 22. |
John AE, etal., Eur J Immunol. 2005 Jan;35(1):108-16. |
| 23. |
Kanno M, etal., J Neuroimmunol. 2005 Oct;167(1-2):72-80. |
| 24. |
Knerlich-Lukoschus F, etal., J Neurosurg Spine. 2011 May;14(5):583-97. Epub 2011 Feb 18. |
| 25. |
Kucuk C, etal., Am J Surg. 2006 Jan;191(1):77-83. |
| 26. |
LaCasse RA, etal., J Neuroimmunol. 2008 May 30;196(1-2):16-26. Epub 2008 Apr 8. |
| 27. |
Liehn EA, etal., J Cell Mol Med. 2008 Apr;12(2):496-506. Epub 2007 Dec 14. |
| 28. |
Lionakis MS, etal., PLoS Pathog. 2012;8(8):e1002865. doi: 10.1371/journal.ppat.1002865. Epub 2012 Aug 16. |
| 29. |
Machado RR, etal., Brain Res. 2007 Jun 9;. |
| 30. |
Manczak M, etal., J Autoimmun. 2002 Jun;18(4):259-70. |
| 31. |
MGD data from the GO Consortium |
| 32. |
Morteau O, etal., Gastroenterology. 2002 Mar;122(3):725-33. |
| 33. |
Ninichuk V, etal., J Am Soc Nephrol. 2005 Apr;16(4):977-85. Epub 2005 Feb 16. |
| 34. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 35. |
Repeke CE, etal., Bone. 2010 Apr;46(4):1122-30. Epub 2010 Jan 4. |
| 36. |
RGD automated data pipeline |
| 37. |
RGD automated import pipeline for gene-chemical interactions |
| 38. |
Shahrara S, etal., Arthritis Rheum. 2003 Dec;48(12):3568-83. |
| 39. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 40. |
Stroo I, etal., Int Immunol. 2010 Jun;22(6):433-42. Epub 2010 Apr 21. |
| 41. |
Sunnemark D, etal., Brain Pathol. 2003 Oct;13(4):617-29. |
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Waehre T, etal., J Am Coll Cardiol. 2003 May 7;41(9):1460-7. |
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Waller A, etal., J Hematother Stem Cell Res. 2000 Oct;9(5):703-9. |
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Xia RH, etal., Neuropathol Appl Neurobiol. 2010 Aug;36(5):388-98. Epub 2010 May 25. |
| 45. |
Yang X, etal., Am J Respir Cell Mol Biol. 2011 Jul;45(1):127-35. Epub 2010 Sep 24. |
| 46. |
Zhang N, etal., Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4536-41. Epub 2005 Mar 11. |
References - uncurated
RGD Disease Portals| Ccr1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ccr1 (Rattus norvegicus) |
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| CCR1 (Homo sapiens) |
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| Ccr1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_020542 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06057727 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01057714 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF119381 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC079207 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473954 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_020542 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_065417 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_065417 | (Get FASTA) |
| GenBank Protein | AAF34340 | (Get FASTA) |
| AAH79207 | (Get FASTA) | |
| EDL76748 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000006715 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000008772 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000008772 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 57301 | ENTREZGENE |
| HomoloGene Group ID | 20344 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7131790 | IMAGE-MGC_LOAD |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/TrEMBL |
| CC_1_rcpt | UniProtKB/TrEMBL | |
| Chmkine_rcpt | UniProtKB/TrEMBL | |
| GPCR_Rhodpsn_supfam | UniProtKB/TrEMBL | |
| IPI | IPI00204201 | UniProtKB/TrEMBL |
| KEGG Report | rno:57301 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:94269 | IMAGE-MGC_LOAD |
| Pfam | 7tm_1 | UniProtKB/TrEMBL |
| PRINTS | CCCHEMOKINER | UniProtKB/TrEMBL |
| CHEMOKINER1 | UniProtKB/TrEMBL | |
| GPCRRHODOPSN | UniProtKB/TrEMBL | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/TrEMBL |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/TrEMBL | |
| UniGene | Rn.34673 | ENTREZGENE |
| UniProt | Q9JLY8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Ccr1 | chemokine (C-C motif) receptor 1 | macrophage inflammatory protein-1 alpha receptor gene | Name updated | 10779 | APPROVED | |
| 2004-09-10 | Ccr1 | macrophage inflammatory protein-1 alpha receptor gene | LOC57301 | Symbol and Name updated | 10779 | APPROVED |
| More on Ccr1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 708446 |
| Created: | 2003-09-23 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




