thalidomide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thalidomide	go back to main search page
Accession:	CHEBI:9513	browse the term
Definition:	A racemate comprising equimolar amounts of R- and S-thalidomide.
Synonyms:	exact_synonym:	rac-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
	related_synonym:	1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline; 2,6-dioxo-3-phthalimidopiperidine; 3-phthalimidoglutarimide; Distaval; Formula=C13H10N2O4; K-17; N-(2,6-dioxo-3-piperidyl)phthalimide; N-Phthalyl-glutaminsaeure-imid; N-phthaloylglutamimide; N-phthalylglutamic acid imide; Sedalis; Softenon; Talimol; alpha-(N-phthalimido)glutarimide; alpha-N-phthalylglutaramide; alpha-phthalimidoglutarimide; talidomida; thalidomidum
	xref:	CAS:50-35-1; DrugBank:DB01041; HMDB:HMDB0015175; KEGG:C07910; KEGG:D00754; LINCS:LSM-1914
	xref_mesh:	MESH:D013792
	xref:	PMID:11349879; PMID:11803357; PMID:12724820; PMID:14689682; PMID:17449064; PMID:18925849; PMID:21207098; PMID:2694291; PMID:8469046; Patent:GB768821; Patent:US2012142734; Patent:WO2013100657; Reaxys:30233; Wikipedia:Thalidomide

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Genes (529)

thalidomide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

decreases expression

Thalidomide results in decreased expression of AADAT mRNA

NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711

G

ATP-binding cassette, sub-family A member 1

increases response to substance

ABCA1 gene SNP results in increased susceptibility to Thalidomide

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 1A

decreases expression
decreases activity

Thalidomide results in decreased expression of ABCB1 mRNA; Thalidomide results in decreased expression of ABCB1 protein
Thalidomide results in decreased activity of ABCB1 protein

PMID:15920492 PMID:19840843

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 1B

increases expression
increases activity

Thalidomide results in increased expression of ABCB1B protein
Thalidomide results in increased activity of ABCB1B protein

NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315

G

acetyl-Coenzyme A acetyltransferase 3

decreases expression

Thalidomide results in decreased expression of ACAT3 mRNA

NCBI chr17:13,142,720...13,159,482
Ensembl chr17:13,142,700...13,159,487

G

acid phosphatase 5, tartrate resistant

multiple interactions

[Thalidomide co-treated with Dexamethasone] results in decreased expression of ACP5 protein

NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007

G

actin alpha 2, smooth muscle, aorta

multiple interactions
decreases expression

[Thalidomide co-treated with Dimethylnitrosamine] results in decreased expression of ACTA2 protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Thalidomide results in decreased expression of ACTA2 protein

PMID:16604421 PMID:16943688 PMID:17030452 PMID:17174718

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

actinin alpha 2

decreases expression

Thalidomide results in decreased expression of ACTN2 mRNA

PMID:26006729 PMID:26217789

NCBI chr13:12,284,312...12,355,613
Ensembl chr13:12,284,312...12,355,641

G

ARP6 actin-related protein 6

decreases expression

Thalidomide results in decreased expression of ACTR6 mRNA

NCBI chr10:89,547,828...89,568,184
Ensembl chr10:89,547,833...89,568,157

G

a disintegrin and metallopeptidase domain 34

increases expression

Thalidomide results in increased expression of ADAM34 mRNA

NCBI chr 8:44,103,346...44,118,597
Ensembl chr 8:44,103,346...44,163,086

G

a disintegrin and metallopeptidase domain 4

decreases expression

Thalidomide results in decreased expression of ADAM4 mRNA

NCBI chr12:81,466,217...81,468,813
Ensembl chr12:81,466,217...81,468,720

G

adenylosuccinate synthase 1

decreases expression

Thalidomide results in decreased expression of ADSS1 mRNA

NCBI chr12:112,586,481...112,607,789
Ensembl chr12:112,586,479...112,607,794

G

AF4/FMR2 family, member 2

decreases expression

Thalidomide results in decreased expression of AFF2 mRNA

NCBI chr X:68,403,796...68,915,660
Ensembl chr X:68,403,900...68,911,643

G

thymoma viral proto-oncogene 1

decreases phosphorylation
increases phosphorylation
decreases activity

Thalidomide analog results in decreased phosphorylation of AKT1 protein
Thalidomide analog results in increased phosphorylation of AKT1 protein
Thalidomide results in decreased activity of AKT1 protein

PMID:15067094 PMID:15858615

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aldehyde dehydrogenase family 1, subfamily A2

decreases expression

Thalidomide results in decreased expression of ALDH1A2 mRNA

NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525

G

alkaline phosphatase, intestinal

increases expression

Thalidomide results in increased expression of ALPI mRNA

NCBI chr 1:87,025,724...87,029,328
Ensembl chr 1:87,025,724...87,029,328

G

alpha-methylacyl-CoA racemase

decreases expression

Thalidomide results in decreased expression of AMACR mRNA

NCBI chr15:10,981,875...10,995,693
Ensembl chr15:10,981,842...10,996,712

G

angiopoietin 2

affects expression

Thalidomide affects the expression of ANGPT2 mRNA

NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578

G

ankyrin repeat domain 37

decreases expression

Thalidomide results in decreased expression of ANKRD37 mRNA

NCBI chr 8:46,449,945...46,452,904
Ensembl chr 8:46,449,939...46,458,744

G

annexin A2

decreases expression

Thalidomide results in decreased expression of ANXA2 mRNA; Thalidomide results in decreased expression of ANXA2 protein

NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077

G

APAF1 interacting protein

decreases expression

Thalidomide results in decreased expression of APIP mRNA

NCBI chr 2:102,904,020...102,922,994
Ensembl chr 2:102,904,020...102,922,989

G

apelin

decreases expression

Thalidomide results in decreased expression of APLN mRNA

NCBI chr X:47,114,023...47,123,730
Ensembl chr X:47,114,023...47,123,730

G

aquaporin 4

increases expression

Thalidomide results in increased expression of AQP4 mRNA

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

aquaporin 5

increases expression

Thalidomide results in increased expression of AQP5 mRNA

NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710

G

Rho GDP dissociation inhibitor alpha

increases expression

Thalidomide results in increased expression of ARHGDIA mRNA

NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450

G

actin related protein 2/3 complex, subunit 4

decreases expression

Thalidomide results in decreased expression of ARPC4 mRNA

NCBI chr 6:113,355,074...113,367,408
Ensembl chr 6:113,355,076...113,367,409

G

aristaless related homeobox

increases expression

Thalidomide results in increased expression of ARX mRNA

NCBI chr X:92,330,113...92,341,963
Ensembl chr X:92,330,051...92,341,963

G

adipocyte-related X-chromosome expressed sequence 1

decreases expression

Thalidomide results in decreased expression of ARXES1 mRNA

NCBI chr X:134,934,116...134,935,695
Ensembl chr X:134,934,116...134,935,695

G

ankyrin repeat and SOCS box-containing 12

decreases expression

Thalidomide results in decreased expression of ASB12 mRNA

NCBI chr X:94,513,125...94,601,610
Ensembl chr X:94,513,807...94,601,593

G

activating transcription factor 3

increases expression

Thalidomide analog results in increased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

aurora kinase A

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA

NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455

G

BCL2-associated X protein

increases expression
multiple interactions

Thalidomide results in increased expression of BAX mRNA
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]

PMID:18291259 PMID:33015978

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell receptor associated protein 29

decreases expression

Thalidomide results in decreased expression of BCAP29 mRNA

NCBI chr12:31,645,353...31,684,657
Ensembl chr12:31,640,966...31,684,657

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

[oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 protein
Thalidomide results in decreased expression of BCL2 protein
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]

PMID:15867202 PMID:15982930 PMID:33015978

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

decreases expression

Thalidomide results in decreased expression of BCL2L1 protein

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

bradykinin receptor, beta 1

multiple interactions

Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]

NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687

G

beclin 1, autophagy related

multiple interactions

Thalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

BCL2/adenovirus E1B 19kD interacting protein like

increases expression

Thalidomide results in increased expression of BNIPL mRNA

NCBI chr 3:95,148,587...95,158,504
Ensembl chr 3:95,148,582...95,158,504

G

biorientation of chromosomes in cell division 1

decreases expression

Thalidomide results in decreased expression of BOD1 mRNA

NCBI chr11:31,615,150...31,621,862
Ensembl chr11:31,615,181...31,621,885

G

bone marrow stromal cell antigen 2

decreases expression

Thalidomide results in decreased expression of BST2 mRNA

NCBI chr 8:71,986,899...71,990,116
Ensembl chr 8:71,986,899...71,990,100

G

butyrophilin-like 5, pseudogene

decreases expression

Thalidomide results in decreased expression of BTNL5-PS mRNA

NCBI chr17:34,706,379...34,716,403
Ensembl chr17:34,707,044...34,714,978

G

BUB1B, mitotic checkpoint serine/threonine kinase

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of BUB1B mRNA

NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072

G

complement component 3

decreases expression

Thalidomide results in decreased expression of C3 protein

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

calcium channel, voltage-dependent, L type, alpha 1C subunit

decreases expression

Thalidomide results in decreased expression of CACNA1C mRNA

PMID:26006729 PMID:26217789

NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851

G

calcium channel, voltage-dependent, beta 4 subunit

decreases expression

Thalidomide results in decreased expression of CACNB4 mRNA

NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843

G

calbindin 1

decreases expression

Thalidomide results in decreased expression of CALB1 mRNA

NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064

G

caspase 3

decreases activity
increases activity
increases expression

Thalidomide results in decreased activity of CASP3 protein
Thalidomide results in increased activity of CASP3 protein
Thalidomide results in increased expression of CASP3 mRNA

PMID:14682394 PMID:15067094 PMID:18291259

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases cleavage
decreases expression

Thalidomide analog results in increased cleavage of CASP8 protein
Thalidomide results in decreased expression of CASP8 mRNA

PMID:15858615 PMID:26217789

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

decreases activity

Thalidomide results in decreased activity of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cytosolic arginine sensor for mTORC1 subunit 1

decreases expression

Thalidomide results in decreased expression of CASTOR1 mRNA

NCBI chr11:4,167,401...4,172,409
Ensembl chr11:4,168,225...4,172,409

G

catalase

multiple interactions

CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

carbonyl reductase 1

decreases expression

Thalidomide results in decreased expression of CBR1 mRNA

NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393

G

coiled-coil domain containing 141

decreases expression

Thalidomide results in decreased expression of CCDC141 mRNA

NCBI chr 2:76,840,246...77,006,424
Ensembl chr 2:76,840,246...77,000,980

G

C-C motif chemokine ligand 2

decreases expression

Thalidomide analog results in decreased expression of CCL2 mRNA

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 3

increases expression

Thalidomide results in increased expression of CCL3 mRNA

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

cyclin A2

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CCNA2 mRNA

NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299

G

cyclin B1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin D1

decreases expression

Thalidomide analog results in decreased expression of CCND1 mRNA

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin O

increases expression

Thalidomide results in increased expression of CCNO mRNA

NCBI chr13:113,124,363...113,127,313
Ensembl chr13:113,124,336...113,127,311

G

CD24a antigen

affects expression

Thalidomide affects the expression of CD24A mRNA

NCBI chr10:43,454,433...43,460,261
Ensembl chr10:43,454,280...43,460,261

G

CD274 antigen

decreases expression
multiple interactions

Thalidomide results in decreased expression of CD274 protein
FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CD274 protein]

NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495

G

cell division cycle 20

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

CDC42 effector protein 5

decreases expression

Thalidomide results in decreased expression of CDC42EP5 mRNA

PMID:26006729 PMID:26217789

NCBI chr 7:4,154,259...4,167,830
Ensembl chr 7:4,154,259...4,167,859

G

cadherin 1

increases expression
multiple interactions

Thalidomide results in increased expression of CDH1 protein
FGD5-AS1 inhibits the reaction [Thalidomide results in increased expression of CDH1 protein]

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 10

decreases expression

Thalidomide results in decreased expression of CDH10 mRNA

NCBI chr15:18,818,763...19,014,883
Ensembl chr15:18,819,033...19,014,322

G

cadherin 2

multiple interactions
decreases expression

FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CDH2 protein]

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cadherin 6

increases expression

Thalidomide results in increased expression of CDH6 mRNA

NCBI chr15:13,028,785...13,176,493
Ensembl chr15:13,028,787...13,173,761

G

cyclin dependent kinase 1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

centromere protein A

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CENPA mRNA

NCBI chr 5:30,824,214...30,832,181
Ensembl chr 5:30,824,121...30,832,174

G

centromere protein F

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CENPF mRNA

NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283

G

cerberus 1, DAN family BMP antagonist

decreases expression

Thalidomide results in decreased expression of CER1 mRNA

NCBI chr 4:82,799,988...82,803,388
Ensembl chr 4:82,799,988...82,803,385

G

cryptic, EGF-CFC family member 1

decreases expression

Thalidomide results in decreased expression of CFC1 mRNA

NCBI chr 1:34,574,729...34,583,392
Ensembl chr 1:34,574,729...34,583,394

G

CASP8 and FADD-like apoptosis regulator

decreases expression

Thalidomide results in decreased expression of CFLAR protein

NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043

G

conserved helix-loop-helix ubiquitous kinase

multiple interactions

Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

churchill domain containing 1

decreases expression

Thalidomide results in decreased expression of CHURC1 mRNA

NCBI chr12:76,812,312...76,829,954
Ensembl chr12:76,812,312...76,829,954

G

claudin 4

increases expression

Thalidomide results in increased expression of CLDN4 mRNA

NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788

G

claudin domain containing 1

decreases expression

Thalidomide results in decreased expression of CLDND1 mRNA

NCBI chr16:58,548,269...58,554,610
Ensembl chr16:58,548,273...58,554,614

G

C-type lectin domain family 9, member a

decreases expression

Thalidomide results in decreased expression of CLEC9A mRNA

NCBI chr 6:129,385,825...129,401,727
Ensembl chr 6:129,385,825...129,401,726

G

collagen, type I, alpha 1

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 protein]

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

multiple interactions

Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

complexin 3

decreases expression

Thalidomide results in decreased expression of CPLX3 mRNA

NCBI chr 9:57,507,275...57,513,564
Ensembl chr 9:57,507,275...57,513,564

G

cereblon

multiple interactions
affects response to substance
affects binding

Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
CRBN gene SNP affects the susceptibility to Thalidomide
Thalidomide binds to [SALL4 protein binds to CRBN protein]; Thalidomide binds to CRBN protein
Thalidomide binds to [CRBN protein binds to DDB1 protein]

PMID:25043012 PMID:25108355 PMID:27751757 PMID:30067223

NCBI chr 6:106,755,205...106,777,060
Ensembl chr 6:106,757,162...106,777,038

G

cAMP responsive element binding protein 5

decreases expression

Thalidomide results in decreased expression of CREB5 mRNA

NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361

G

CREB3 regulatory factor

increases expression

Thalidomide analog results in increased expression of CREBRF mRNA

NCBI chr17:26,918,716...26,995,611
Ensembl chr17:26,934,624...26,995,609

G

cripto, EGF-CFC family member

decreases expression

Thalidomide results in decreased expression of CRIPTO mRNA

PMID:26006729 PMID:26217789

NCBI chr 9:110,768,676...110,775,226
Ensembl chr 9:110,768,671...110,775,226

G

C-reactive protein, pentraxin-related

decreases expression

Thalidomide results in decreased expression of CRP protein

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

colony stimulating factor 2 (granulocyte-macrophage)

decreases activity

Thalidomide results in decreased activity of CSF2 protein

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

colony stimulating factor 3 (granulocyte)

decreases activity

Thalidomide results in decreased activity of CSF3 protein

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

chondroitin sulfate N-acetylgalactosaminyltransferase 2

decreases expression

Thalidomide results in decreased expression of CSGALNACT2 mRNA

NCBI chr 6:118,084,413...118,116,132
Ensembl chr 6:118,084,413...118,116,101

G

C-X-C motif chemokine ligand 10

increases expression

Thalidomide results in increased expression of CXCL10

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 15

multiple interactions
decreases activity

Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
Thalidomide results in decreased activity of CXCL8 protein

PMID:15687330 PMID:17557286

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine receptor 1

decreases expression

Thalidomide results in decreased expression of CXCR1 protein

NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790

G

C-X-C motif chemokine receptor 2

decreases expression

Thalidomide results in decreased expression of CXCR2 protein

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

cytochrome c, somatic

increases expression

Thalidomide results in increased expression of CYCS protein

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 2, subfamily b, polypeptide 10

increases expression

Thalidomide results in increased expression of CYP2B6 mRNA

PMID:24460184 PMID:28496040

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily c, polypeptide 38

increases hydroxylation
multiple interactions
increases oxidation

CYP2C19 protein results in increased hydroxylation of Thalidomide
[CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide

PMID:20443640 PMID:24350712

NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519

G

cytochrome P450, family 3, subfamily a, polypeptide 13

multiple interactions
increases hydroxylation
increases expression
increases metabolic processing

[CYP3A7 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
Thalidomide results in increased expression of CYP3A5 mRNA
CYP3A5 protein results in increased metabolism of Thalidomide
[CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide

PMID:20443640 PMID:28496040 PMID:28745489

NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881

G

cytohesin 3

decreases expression

Thalidomide results in decreased expression of CYTH3 mRNA

NCBI chr 5:143,608,202...143,696,005
Ensembl chr 5:143,608,202...143,696,005

G

dishevelled associated activator of morphogenesis 2

decreases expression

Thalidomide results in decreased expression of DAAM2 mRNA

NCBI chr17:49,763,050...49,871,517
Ensembl chr17:49,763,050...49,871,371

G

dihydrolipoamide branched chain transacylase E2

decreases expression

Thalidomide results in decreased expression of DBT mRNA

NCBI chr 3:116,306,776...116,343,630
Ensembl chr 3:116,306,719...116,343,630

G

damage specific DNA binding protein 1

affects binding

Thalidomide binds to [CRBN protein binds to DDB1 protein]

NCBI chr19:10,582,961...10,607,186
Ensembl chr19:10,582,691...10,607,183

G

DNA-damage inducible transcript 3

increases expression

Thalidomide analog results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

defensin, alpha, 3

increases expression

Thalidomide results in increased expression of DEFA3 mRNA

NCBI chr 8:21,777,425...21,778,393
Ensembl chr 8:21,777,425...21,778,393

G

defensin beta 15

increases expression

Thalidomide results in increased expression of DEFB15 mRNA

NCBI chr 8:22,419,813...22,422,728
Ensembl chr 8:22,419,815...22,422,726

G

desmin

multiple interactions

Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of DES protein]

NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223

G

dexamethasone-induced transcript

increases expression

Thalidomide results in increased expression of DEXI mRNA

NCBI chr16:10,348,071...10,360,918
Ensembl chr16:10,320,395...10,360,918

G

DLG associated protein 5

decreases expression

Thalidomide results in decreased expression of DLGAP5 mRNA

NCBI chr14:47,625,238...47,655,657
Ensembl chr14:47,625,236...47,655,864

G

delta like non-canonical Notch ligand 1

decreases expression

Thalidomide results in decreased expression of DLK1 mRNA

NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

Thalidomide analog results in increased expression of DNAJB1 mRNA

NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Thalidomide analog results in increased expression of DNAJB4 mRNA

NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Thalidomide analog results in increased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Thalidomide results in decreased expression of DNAJC19 mRNA

NCBI chr 3:34,111,429...34,135,503
Ensembl chr 3:34,110,169...34,135,470

G

dihydrouridine synthase 4 like

decreases expression

Thalidomide results in decreased expression of DUS4L mRNA

NCBI chr12:31,690,049...31,704,834
Ensembl chr12:31,690,049...31,704,825

G

dual specificity phosphatase 1

increases expression

Thalidomide analog results in increased expression of DUSP1 mRNA

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

dual specificity phosphatase 10

increases expression

Thalidomide analog results in increased expression of DUSP10 mRNA

NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833

G

dual specificity phosphatase 8

increases expression

Thalidomide analog results in increased expression of DUSP8 mRNA

NCBI chr 7:141,633,224...141,649,799
Ensembl chr 7:141,633,227...141,649,580

G

eukaryotic translation elongation factor 1 epsilon 1

decreases expression

Thalidomide results in decreased expression of EEF1E1 mRNA

NCBI chr13:38,829,667...38,843,004
Ensembl chr13:38,828,183...38,843,034

G

EF-hand calcium binding domain 2

decreases expression

Thalidomide results in decreased expression of EFCAB2 mRNA

NCBI chr 1:178,233,583...178,312,078
Ensembl chr 1:178,233,650...178,312,078

G

eukaryotic translation initiation factor 1B

decreases expression

Thalidomide results in decreased expression of EIF1B mRNA

NCBI chr 9:120,321,672...120,324,393
Ensembl chr 9:120,321,298...120,324,396

G

eukaryotic translation initiation factor 4E

decreases expression

Thalidomide results in decreased expression of EIF4E protein

NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457

G

elastase, neutrophil expressed

multiple interactions

Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein]

NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049

G

ER membrane protein complex subunit 8

decreases expression

Thalidomide results in decreased expression of EMC8 mRNA

NCBI chr 8:121,380,653...121,394,826
Ensembl chr 8:121,380,653...121,395,312

G

Eph receptor A10

decreases expression

Thalidomide results in decreased expression of EPHA10 mRNA

NCBI chr 4:124,775,408...124,811,594
Ensembl chr 4:124,774,692...124,811,593

G

Eph receptor B1

decreases expression

Thalidomide results in decreased expression of EPHB1 mRNA

NCBI chr 9:101,799,327...102,231,892
Ensembl chr 9:101,799,327...102,231,892

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

[ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

esterase D/formylglutathione hydrolase

decreases expression

Thalidomide results in decreased expression of ESD mRNA

NCBI chr14:74,969,591...74,988,205
Ensembl chr14:74,969,737...74,988,205

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

Thalidomide results in decreased expression of EYA1 mRNA

NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459

G

coagulation factor II thrombin receptor

decreases expression

Thalidomide results in decreased expression of F2R mRNA; Thalidomide results in decreased expression of F2R protein

NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995

G

fatty acid binding protein 5, epidermal

decreases expression

Thalidomide results in decreased expression of FABP5 mRNA

NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667

G

fatty acid binding protein 7, brain

affects expression

Thalidomide affects the expression of FABP7 mRNA

NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546

G

family with sequence similarity 174, member B

decreases expression

Thalidomide results in decreased expression of FAM174B mRNA

NCBI chr 7:73,390,055...73,426,667
Ensembl chr 7:73,390,050...73,426,667

G

Fas cell surface death receptor

decreases expression
increases expression

Thalidomide results in decreased expression of FAS protein
Thalidomide results in increased expression of FAS mRNA

PMID:16531263 PMID:18291259

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

multiple interactions
decreases expression

Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]
Thalidomide results in decreased expression of FASLG protein

PMID:16510725 PMID:16531263

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

flap structure specific endonuclease 1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA

NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533

G

FYVE, RhoGEF and PH domain containing 3

increases expression

Thalidomide results in increased expression of FGD3 mRNA

NCBI chr13:49,415,030...49,473,783
Ensembl chr13:49,415,030...49,473,787

G

fibroblast growth factor 2

increases response to substance
affects expression
affects secretion
multiple interactions
decreases activity
decreases expression

FGF2 protein results in increased susceptibility to Thalidomide
Thalidomide affects the expression of FGF2 mRNA; Thalidomide affects the expression of FGF2 protein
Thalidomide affects the secretion of FGF2 protein
Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased activity of FGF2 protein
[Temozolomide co-treated with Thalidomide] results in decreased expression of FGF2 protein; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]
Thalidomide results in decreased expression of FGF2 protein

PMID:11555579 PMID:12644816 PMID:14558594 PMID:15863203 PMID:15939924 More...

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 8

increases expression

Thalidomide results in increased expression of FGF8 mRNA

NCBI chr19:45,724,930...45,731,380
Ensembl chr19:45,725,237...45,731,354

G

fibroblast growth factor receptor 1

affects expression

Thalidomide affects the expression of FGFR1 mRNA

NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734

G

fibroblast growth factor receptor 2

decreases expression

Thalidomide results in decreased expression of FGFR2 mRNA; Thalidomide results in decreased expression of FGFR2 protein

NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079

G

fibroblast growth factor receptor 3

affects expression

Thalidomide affects the expression of FGFR3 mRNA

NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412

G

FBJ osteosarcoma oncogene

increases expression

Thalidomide analog results in increased expression of FOS mRNA

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

FBJ osteosarcoma oncogene B

increases expression

Thalidomide analog results in increased expression of FOSB mRNA

NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976

G

forkhead box C2

decreases expression

Thalidomide results in decreased expression of FOXC2 mRNA

NCBI chr 8:121,842,910...121,845,634
Ensembl chr 8:121,842,910...121,845,634

G

FAD-dependent oxidoreductase domain containing 1

decreases expression

Thalidomide results in decreased expression of FOXRED1 mRNA

NCBI chr 9:35,115,504...35,122,499
Ensembl chr 9:35,115,502...35,122,351

G

frizzled class receptor 8

decreases expression

Thalidomide results in decreased expression of FZD8 mRNA

NCBI chr18:9,212,856...9,216,201
Ensembl chr18:9,212,163...9,218,136

G

growth factor receptor bound protein 2-associated protein 3

decreases expression

Thalidomide results in decreased expression of GAB3 mRNA

NCBI chr X:74,032,151...74,128,511
Ensembl chr X:74,010,449...74,129,064

G

growth arrest and DNA-damage-inducible 45 beta

multiple interactions

Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]

NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038

G

galactose mutarotase

decreases expression

Thalidomide results in decreased expression of GALM mRNA

NCBI chr17:80,434,886...80,492,461
Ensembl chr17:80,434,900...80,492,530

G

GATA binding protein 3

increases expression

Thalidomide results in increased expression of GATA3 protein

NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845

G

glucosaminyl (N-acetyl) transferase 2 (I blood group)

decreases expression

Thalidomide results in decreased expression of GCNT2 mRNA

NCBI chr13:41,013,417...41,114,368
Ensembl chr13:41,013,230...41,114,368

G

gem nuclear organelle associated protein 2

decreases expression

Thalidomide results in decreased expression of GEMIN2 mRNA

NCBI chr12:59,060,177...59,075,256
Ensembl chr12:59,060,179...59,075,256

G

glial cell line derived neurotrophic factor family receptor alpha 2

decreases expression

Thalidomide results in decreased expression of GFRA2 mRNA

NCBI chr14:71,127,547...71,217,280
Ensembl chr14:71,127,560...71,217,278

G

glutamic-oxaloacetic transaminase 1, soluble

increases expression

Thalidomide results in increased expression of GOT1 mRNA

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glycoprotein 2 zymogen granule membrane

increases expression

Thalidomide results in increased expression of GP2 mRNA

NCBI chr 7:119,041,760...119,058,495
Ensembl chr 7:119,041,760...119,058,508

G

G patch domain containing 4

decreases expression

Thalidomide results in decreased expression of GPATCH4 mRNA

NCBI chr 3:87,950,413...87,963,301
Ensembl chr 3:87,950,415...87,963,300

G

glutathione peroxidase 1

multiple interactions

Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein]

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 8 (putative)

decreases expression

Thalidomide results in decreased expression of GPX8 mRNA

NCBI chr13:113,179,287...113,182,944
Ensembl chr13:113,179,287...113,182,944

G

glutamate receptor, ionotropic, AMPA3 (alpha 3)

decreases expression

Thalidomide results in decreased expression of GRIA3 mRNA

NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478

G

glutamate receptor, ionotropic, AMPA4 (alpha 4)

increases expression

Thalidomide results in increased expression of GRIA4 mRNA

NCBI chr 9:4,417,893...4,796,250
Ensembl chr 9:4,417,896...4,796,234

G

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

decreases expression

Thalidomide results in decreased expression of GRIN2A mRNA

NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424

G

glutamate receptor, ionotropic, NMDA2C (epsilon 3)

decreases expression

Thalidomide results in decreased expression of GRIN2C mRNA

NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069

G

general transcription factor II E, polypeptide 1 (alpha subunit)

decreases expression

Thalidomide results in decreased expression of GTF2E1 mRNA

NCBI chr16:37,330,158...37,360,151
Ensembl chr16:37,330,152...37,360,151

G

GULP, engulfment adaptor PTB domain containing 1

decreases expression

Thalidomide results in decreased expression of GULP1 mRNA

NCBI chr 1:44,590,540...44,835,998
Ensembl chr 1:44,590,671...44,835,998

G

histocompatibility 2, Q region locus 1

increases expression

Thalidomide results in increased expression of H2-Q1 mRNA

NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075

G

histocompatibility 2, T region locus 23

affects expression

Thalidomide affects the expression of HLA-E mRNA

NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747

G

H2A clustered histone 6

decreases expression

Thalidomide results in decreased expression of H2AC15 mRNA

NCBI chr13:23,867,456...23,867,942
Ensembl chr13:23,865,450...23,867,931

G

H2B clustered histone 12

decreases expression

Thalidomide results in decreased expression of H2BC12 mRNA

NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515

G

H2B clustered histone 27

decreases expression

Thalidomide results in decreased expression of H2BC27 mRNA

NCBI chr11:58,839,737...58,840,198
Ensembl chr11:58,839,746...58,840,359

G

H2B clustered histone 4

decreases expression

Thalidomide results in decreased expression of H2BC4 mRNA

NCBI chr13:23,868,182...23,876,805
Ensembl chr13:23,868,182...23,876,891

G

H3 clustered histone 1

decreases expression

Thalidomide results in decreased expression of H3C1 mRNA

NCBI chr13:23,945,868...23,946,369
Ensembl chr13:23,945,836...23,946,369

G

H3 clustered histone 7

decreases expression

Thalidomide results in decreased expression of H3C15 mRNA

NCBI chr13:23,728,222...23,729,124
Ensembl chr13:23,728,222...23,729,482

G

H4 clustered histone 11

decreases expression

Thalidomide results in decreased expression of H4C11 mRNA

NCBI chr13:21,919,204...21,919,626
Ensembl chr13:21,919,234...21,920,007

G

H4 clustered histone 14

decreases expression

Thalidomide results in decreased expression of H4C3 mRNA

NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627

G

H4 clustered histone 2

decreases expression

Thalidomide results in decreased expression of H4C14 mRNA

NCBI chr13:23,940,920...23,941,369
Ensembl chr13:23,940,996...23,941,392

G

H4 clustered histone 4

decreases expression

Thalidomide results in decreased expression of H4C4 mRNA

NCBI chr13:23,765,551...23,765,952
Ensembl chr13:23,765,581...23,766,718

G

hyperpolarization activated cyclic nucleotide gated potassium channel 1

decreases expression

Thalidomide results in decreased expression of HCN1 mRNA

NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954

G

histone deacetylase 6

multiple interactions

HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of NFKBIA protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]]; Thalidomide inhibits the reaction [Paraquat results in increased expression of HDAC6 mRNA]

NCBI chr X:7,796,355...7,814,284
Ensembl chr X:7,796,359...7,814,128

G

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

increases expression

Thalidomide analog results in increased expression of HERPUD1 mRNA

NCBI chr 8:95,113,057...95,121,999
Ensembl chr 8:95,113,066...95,122,005

G

hepatocyte growth factor

affects expression
decreases activity
affects secretion

Thalidomide affects the expression of HGF mRNA; Thalidomide affects the expression of HGF protein
Thalidomide results in decreased activity of HGF protein
Thalidomide affects the secretion of HGF protein

PMID:15939924 PMID:17557286

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

HIRA interacting protein 3

decreases expression

Thalidomide results in decreased expression of HIRIP3 mRNA

NCBI chr 7:126,461,155...126,464,549
Ensembl chr 7:126,461,144...126,464,549

G

high-mobility group nucleosome binding domain 5

decreases expression

Thalidomide results in decreased expression of HMGN5 mRNA

NCBI chr X:108,048,143...108,056,986
Ensembl chr X:108,048,140...108,057,010

G

homeobox B7

increases expression

Thalidomide results in increased expression of HOXB7 mRNA

NCBI chr11:96,176,431...96,180,989
Ensembl chr11:96,177,449...96,180,988

G

homeobox B9

increases expression

Thalidomide results in increased expression of HOXB9 mRNA

NCBI chr11:96,162,156...96,167,421
Ensembl chr11:96,162,283...96,167,421

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

Thalidomide results in decreased expression of HSD11B2 mRNA

NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620

G

heat shock factor 1

decreases expression

Thalidomide results in decreased expression of HSF1 mRNA

PMID:26006729 PMID:26217789

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 1

decreases expression

Thalidomide results in decreased expression of HSPB1 mRNA

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

heat shock 105kDa/110kDa protein 1

increases expression

Thalidomide analog results in increased expression of HSPH1 mRNA

NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841

G

intercellular adhesion molecule 1

increases response to substance
decreases expression

ICAM1 gene SNP results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of ICAM1 mRNA; Thalidomide results in decreased expression of ICAM1 protein

PMID:17174718 PMID:21245421

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

idnK gluconokinase homolog (E. coli)

decreases expression

Thalidomide results in decreased expression of IDNK mRNA

NCBI chr13:58,305,076...58,315,358
Ensembl chr13:58,305,463...58,312,507

G

interferon gamma

multiple interactions
affects expression
increases expression
decreases expression

[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
Thalidomide affects the expression of IFNG mRNA
Thalidomide results in increased expression of IFNG; Thalidomide results in increased expression of IFNG protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IFNG protein]
Thalidomide results in decreased expression of IFNG protein

PMID:15588918 PMID:16078585 PMID:16454849 PMID:16514283 PMID:16815871 More...

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

intraflagellar transport 27

decreases expression

Thalidomide results in decreased expression of IFT27 mRNA

PMID:26006729 PMID:26217789

NCBI chr15:78,043,660...78,058,281
Ensembl chr15:78,043,663...78,058,307

G

intraflagellar transport 70A1

decreases expression

Thalidomide results in decreased expression of IFT70A1 mRNA

NCBI chr 2:75,809,450...75,812,311
Ensembl chr 2:75,808,591...75,812,311

G

intraflagellar transport 74

decreases expression

Thalidomide results in decreased expression of IFT74 mRNA

NCBI chr 4:94,491,503...94,581,470
Ensembl chr 4:94,502,728...94,581,466

G

insulin-like growth factor 1

affects expression

Thalidomide affects the expression of IGF1 mRNA

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor binding protein 3

affects expression
decreases expression

Thalidomide affects the expression of IGFBP3 mRNA
Thalidomide results in decreased expression of IGFBP3 mRNA

PMID:15939924 PMID:26217789

NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923

G

immunoglobulin heavy variable V9-2

increases expression

Thalidomide results in increased expression of IGHV9-2 mRNA

NCBI chr12:114,072,621...114,073,050
Ensembl chr12:114,072,621...114,073,050

G

immunoglobulin kappa chain variable 8-30

decreases expression

Thalidomide results in decreased expression of IGKV8-30 mRNA

NCBI chr 6:70,094,045...70,094,601
Ensembl chr 6:70,094,045...70,094,604

G

interleukin 10

affects expression
decreases expression

Thalidomide affects the expression of IL10 mRNA
Thalidomide results in decreased expression of IL10 protein

PMID:16454849 PMID:16514283

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 12a

multiple interactions

Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]

NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880

G

interleukin 12b

multiple interactions

Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]
Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]

PMID:11788559 PMID:16510725

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 18

increases expression

Thalidomide results in increased expression of IL18

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 beta

decreases expression
multiple interactions

Thalidomide results in decreased expression of IL1B protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IL1B protein]
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]

PMID:15863203 PMID:16815871 PMID:23510834 PMID:25478868

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor, type I

decreases expression

Thalidomide results in decreased expression of IL1R1 mRNA

NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417

G

interleukin 1 receptor antagonist

multiple interactions

Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 2

multiple interactions
decreases expression

[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
Thalidomide results in decreased expression of IL2 protein
Thalidomide inhibits the reaction [irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [irinotecan results in decreased expression of IL2 protein]

PMID:15588918 PMID:16815871

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 4

increases expression

Thalidomide results in increased expression of IL4 protein

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 6

decreases secretion
decreases activity
multiple interactions

Thalidomide analog results in decreased secretion of IL6 protein
Thalidomide results in decreased activity of IL6 protein
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]

PMID:15858615 PMID:16815871 PMID:17557286 PMID:23510834 PMID:25478868 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 signal transducer

decreases expression

Thalidomide results in decreased expression of IL6ST mRNA

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

inhibitor of growth family, member 3

increases expression

Thalidomide analog results in increased expression of ING3 mRNA

NCBI chr 6:21,948,002...21,976,037
Ensembl chr 6:21,949,570...21,976,037

G

IAP promoted placental gene

decreases expression

Thalidomide results in decreased expression of IPP mRNA

NCBI chr 4:116,364,710...116,400,607
Ensembl chr 4:116,364,746...116,395,440

G

jun proto-oncogene

increases expression

Thalidomide analog results in increased expression of JUN mRNA

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

kalirin, RhoGEF kinase

decreases expression

Thalidomide results in decreased expression of KALRN mRNA

NCBI chr16:33,789,443...34,393,647
Ensembl chr16:33,789,443...34,393,902

G

kinase insert domain protein receptor

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

kinesin family member 2C

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNA

NCBI chr 4:117,016,830...117,039,821
Ensembl chr 4:117,016,836...117,039,836

G

kelch-like 4

decreases expression

Thalidomide results in decreased expression of KLHL4 mRNA

NCBI chr X:113,384,030...113,470,826
Ensembl chr X:113,384,030...113,470,526

G

kallikrein 1

decreases expression

Thalidomide results in decreased expression of KLK1 mRNA

NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042

G

killer cell lectin-like receptor subfamily A, member 14, pseudogene

increases expression

Thalidomide results in increased expression of KLRA14-PS mRNA

NCBI chr 6:130,126,069...130,137,711
Ensembl chr 6:130,126,069...130,137,711

G

keratin associated protein 1-4

increases expression

Thalidomide results in increased expression of KRTAP1-4 mRNA

NCBI chr11:99,473,375...99,474,503
Ensembl chr11:99,473,888...99,474,480

G

large tumor suppressor 2

increases expression

Thalidomide analog results in increased expression of LATS2 mRNA

NCBI chr14:57,927,119...57,983,669
Ensembl chr14:57,927,119...57,995,845
Ensembl chr14:57,927,119...57,995,845

G

left-right determination factor 2

decreases expression

Thalidomide results in decreased expression of LEFTY2 mRNA

NCBI chr 1:180,720,673...180,726,672
Ensembl chr 1:180,720,673...180,726,668

G

leucine rich repeat protein 1

decreases expression

Thalidomide results in decreased expression of LRR1 mRNA

NCBI chr12:69,215,588...69,225,786
Ensembl chr12:69,215,588...69,225,783

G

lactotransferrin

multiple interactions

Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein]

NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835

G

lymphocyte antigen 6 family member G

increases expression

Thalidomide results in increased expression of LY6G mRNA

NCBI chr15:75,027,110...75,030,977
Ensembl chr15:75,027,089...75,030,975

G

lymphocyte antigen 96

decreases expression

Thalidomide results in decreased expression of LY96 mRNA

PMID:26006729 PMID:26217789

NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835

G

LYR motif containing 2

decreases expression

Thalidomide results in decreased expression of LYRM2 mRNA

NCBI chr 4:32,800,259...32,802,268
Ensembl chr 4:32,800,253...32,801,559

G

LYR motif containing 4

decreases expression

Thalidomide results in decreased expression of LYRM4 mRNA

NCBI chr13:36,162,778...36,301,543
Ensembl chr13:36,162,378...36,301,509

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Thalidomide promotes the reaction [temozolomide results in increased expression of MAP1LC3B protein]

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

mitogen-activated protein kinase 1

increases phosphorylation

Thalidomide analog results in increased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

increases phosphorylation

Thalidomide analog results in increased phosphorylation of MAPK14 protein

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

increases phosphorylation

Thalidomide analog results in increased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

myeloid cell leukemia sequence 1

decreases expression

Thalidomide analog results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

minichromosome maintenance complex component 5

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA

NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067

G

mast cell protease 8

increases expression

Thalidomide results in increased expression of MCPT8 mRNA

NCBI chr14:56,319,620...56,322,951
Ensembl chr14:56,319,623...56,322,730

G

Meis homeobox 2

multiple interactions

Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]

NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320

G

mesenchyme homeobox 1

decreases expression

Thalidomide results in decreased expression of MEOX1 mRNA

NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200

G

mesoderm posterior 2

decreases expression

Thalidomide results in decreased expression of MESP2 mRNA

NCBI chr 7:79,460,475...79,463,179
Ensembl chr 7:79,460,475...79,463,187

G

methyltransferase 5, N6-adenosine

decreases expression

Thalidomide results in decreased expression of METTL5 mRNA

NCBI chr 2:69,701,539...69,717,961
Ensembl chr 2:69,701,542...69,715,959

G

microRNA 101c

increases expression

Thalidomide results in increased expression of MIR101C mRNA

NCBI chr 9:3,038,669...3,038,743
Ensembl chr 9:3,038,669...3,038,743

G

microRNA 126a

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in decreased expression of MIR126]

NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441

G

microRNA 141

multiple interactions

MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; Thalidomide inhibits the reaction [Paraquat results in decreased expression of MIR141]

NCBI chr 6:124,694,877...124,694,948
Ensembl chr 6:124,694,877...124,694,948

G

microRNA 206

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of MIR206]

NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306

G

microRNA 21a

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in decreased expression of MIR21]

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

microRNA 221

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of MIR221]

NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627

G

microRNA 222

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of MIR222]

NCBI chr X:19,013,132...19,013,210
Ensembl chr X:19,013,132...19,013,210

G

microRNA 301b

increases expression

Thalidomide results in increased expression of MIR301B mRNA

NCBI chr16:16,942,264...16,942,360
Ensembl chr16:16,942,264...16,942,360

G

microRNA 3081

increases expression

Thalidomide results in increased expression of MIR3081 mRNA

NCBI chr16:44,378,409...44,378,492
Ensembl chr16:44,378,409...44,378,492

G

microRNA 3095

decreases expression

Thalidomide results in decreased expression of MIR3095 mRNA

NCBI chr 4:58,441,012...58,441,098
Ensembl chr 4:58,441,012...58,441,098

G

microRNA 30e

decreases expression

Thalidomide results in decreased expression of MIR30E mRNA

NCBI chr 4:120,629,803...120,629,894
Ensembl chr 4:120,629,803...120,629,894

G

microRNA 3102

increases expression

Thalidomide results in increased expression of MIR3102 mRNA

NCBI chr 7:100,531,513...100,531,616
Ensembl chr 7:100,531,513...100,531,616

G

microRNA 3473b

increases expression

Thalidomide results in increased expression of MIR3473B mRNA

NCBI chr10:41,546,735...41,546,789
Ensembl chr10:41,546,735...41,546,789

G

microRNA 3965

decreases expression

Thalidomide results in decreased expression of MIR3965 mRNA

NCBI chr 5:134,355,308...134,355,376
Ensembl chr 5:134,355,308...134,355,376

G

microRNA 449c

increases expression

Thalidomide results in increased expression of MIR449C mRNA

NCBI chr13:113,172,517...113,172,625
Ensembl chr13:113,172,517...113,172,625

G

microRNA 5103

increases expression

Thalidomide results in increased expression of MIR5103 mRNA

NCBI chr 1:34,472,202...34,472,280
Ensembl chr 1:34,472,202...34,472,280

G

Mix paired-like homeobox

decreases expression

Thalidomide results in decreased expression of MIXL1 mRNA

NCBI chr 1:180,520,608...180,524,599
Ensembl chr 1:180,520,608...180,524,599

G

antigen identified by monoclonal antibody Ki 67

multiple interactions
decreases expression

[Azacitidine co-treated with Thalidomide] affects the expression of MKI67 mRNA
Thalidomide results in decreased expression of MKI67 protein

PMID:18720364 PMID:34520751

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

myeloid leukemia factor 2

decreases expression

Thalidomide results in decreased expression of MLF2 mRNA

NCBI chr 6:124,908,351...124,913,112
Ensembl chr 6:124,908,349...124,914,201

G

membrane metallo endopeptidase

decreases expression

Thalidomide results in decreased expression of MME mRNA

NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451

G

matrix metallopeptidase 2

multiple interactions
decreases expression

Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased expression of MMP2 protein

PMID:14558594 PMID:15863203

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

decreases expression

Thalidomide results in decreased expression of MMP9 protein

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

monooxygenase, DBH-like 1

decreases expression

Thalidomide results in decreased expression of MOXD1 mRNA

NCBI chr10:24,099,415...24,178,681
Ensembl chr10:24,099,415...24,178,688

G

myeloperoxidase

multiple interactions

Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:15138204 PMID:25478868

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

membrane protein, palmitoylated

decreases expression

Thalidomide results in decreased expression of MPP1 mRNA

NCBI chr X:74,153,339...74,174,622
Ensembl chr X:74,153,339...74,174,622

G

mitochondrial ribosomal protein L32

decreases expression

Thalidomide results in decreased expression of MRPL32 mRNA

NCBI chr13:14,784,886...14,787,622
Ensembl chr13:14,782,769...14,787,750

G

mitochondrial ribosomal protein L34

decreases expression

Thalidomide results in decreased expression of MRPL34 mRNA

NCBI chr 8:71,917,570...71,918,397
Ensembl chr 8:71,917,603...71,918,391

G

mitochondrial ribosomal protein L47

decreases expression

Thalidomide results in decreased expression of MRPL47 mRNA

NCBI chr 3:32,781,646...32,790,904
Ensembl chr 3:32,779,546...32,791,754

G

mitochondrial ribosomal protein L52

decreases expression

Thalidomide results in decreased expression of MRPL52 mRNA

NCBI chr14:54,664,366...54,667,207
Ensembl chr14:54,664,366...54,667,213

G

mitochondrial ribosomal protein S21

decreases expression

Thalidomide results in decreased expression of MRPS21 mRNA

NCBI chr 3:95,769,946...95,778,826
Ensembl chr 3:95,769,946...95,778,831

G

mitochondrial fission regulator 2

decreases expression

Thalidomide results in decreased expression of MTFR2 mRNA

NCBI chr10:20,223,491...20,237,415
Ensembl chr10:20,223,516...20,237,050

G

major urinary protein 6

decreases expression

Thalidomide results in decreased expression of MUP6 mRNA

NCBI chr 4:60,003,481...60,007,274
Ensembl chr 4:59,964,294...60,007,274

G

myeloblastosis oncogene

multiple interactions
decreases activity
decreases phosphorylation

CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]
Thalidomide results in decreased phosphorylation of MYB protein

NCBI chr10:21,000,829...21,036,883
Ensembl chr10:21,000,834...21,036,883

G

myosin binding protein C, cardiac

decreases expression

Thalidomide results in decreased expression of MYBPC3 mRNA

PMID:26006729 PMID:26217789

NCBI chr 2:90,948,459...90,966,862
Ensembl chr 2:90,948,489...90,966,861

G

myeloid differentiation primary response gene 88

decreases expression

Thalidomide results in decreased expression of MYD88 mRNA

PMID:26006729 PMID:26217789

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

myosin, heavy polypeptide 6, cardiac muscle, alpha

affects expression

Thalidomide affects the expression of MYH6 mRNA

PMID:26006729 PMID:26217789

NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384

G

myosin, light polypeptide 3

affects expression
decreases expression

Thalidomide affects the expression of MYL3 mRNA
Thalidomide results in decreased expression of MYL3 mRNA

PMID:26006729 PMID:26217789

NCBI chr 9:110,592,746...110,598,870
Ensembl chr 9:110,570,929...110,598,866

G

myosin, light polypeptide 7, regulatory

decreases expression

Thalidomide results in decreased expression of MYL7 mRNA

NCBI chr11:5,846,637...5,848,782
Ensembl chr11:5,846,637...5,848,782

G

myosin, light polypeptide kinase

increases expression

Thalidomide results in increased expression of MYLK mRNA

NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790

G

myomesin 1

decreases expression

Thalidomide results in decreased expression of MYOM1 mRNA

PMID:26006729 PMID:26217789

NCBI chr17:71,326,455...71,433,851
Ensembl chr17:71,309,628...71,433,851

G

N(alpha)-acetyltransferase 20, NatB catalytic subunit

decreases expression

Thalidomide results in decreased expression of NAA20 mRNA

NCBI chr 2:145,743,454...145,758,345
Ensembl chr 2:145,744,019...145,758,345

G

Nanog homeobox

decreases expression

Thalidomide results in decreased expression of NANOG mRNA

NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592

G

NAD(P)HX epimerase

decreases expression

Thalidomide results in decreased expression of NAXE mRNA

NCBI chr 3:87,963,827...87,965,851
Ensembl chr 3:87,963,827...87,965,802

G

NADH:ubiquinone oxidoreductase subunit B8

decreases expression

Thalidomide results in decreased expression of NDUFB8 mRNA

NCBI chr19:44,537,010...44,543,881
Ensembl chr19:44,537,011...44,543,879

G

nebulette

decreases expression

Thalidomide results in decreased expression of NEBL mRNA

NCBI chr 2:17,347,484...17,740,634
Ensembl chr 2:17,348,720...17,736,275

G

neurogenic differentiation 4

increases expression

Thalidomide results in increased expression of NEUROD4 mRNA

NCBI chr10:130,104,021...130,116,123
Ensembl chr10:130,104,021...130,116,109

G

neurogenin 2

increases expression

Thalidomide results in increased expression of NEUROG2 mRNA

NCBI chr 3:127,426,382...127,429,285
Ensembl chr 3:127,426,784...127,429,280

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 protein]

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions
decreases expression

[resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]
Thalidomide results in decreased expression of NFKB1 protein

PMID:16333628 PMID:17164350

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions
increases expression

Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of NFKBIA protein]]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]; Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Thalidomide results in increased expression of NFKBIA protein

PMID:15687330 PMID:16288038 PMID:16604421 PMID:16943688 PMID:17174718 More...

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nescient helix loop helix 1

increases expression

Thalidomide results in increased expression of NHLH1 mRNA

NCBI chr 1:171,879,859...171,885,163
Ensembl chr 1:171,879,859...171,885,140

G

neuromedin S

increases expression

Thalidomide results in increased expression of NMS mRNA

NCBI chr 1:38,978,230...38,989,357
Ensembl chr 1:38,978,230...38,989,357

G

nitric oxide synthase 2, inducible

multiple interactions

Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of NOS2 mRNA]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

natriuretic peptide type B

multiple interactions

[Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

N-ribosyldihydronicotinamide quinone reductase 2

decreases expression

Thalidomide results in decreased expression of NQO2 mRNA

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

G

nuclear receptor subfamily 1, group H, member 5

decreases expression

Thalidomide results in decreased expression of NR1H5 mRNA

NCBI chr 3:102,846,974...102,871,607
Ensembl chr 3:102,846,974...102,871,449

G

nuclear receptor subfamily 1, group I, member 2

increases expression

Thalidomide results in increased expression of NR1I2 mRNA

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Thalidomide analog results in increased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

nuclear receptor subfamily 4, group A, member 2

increases expression

Thalidomide analog results in increased expression of NR4A2 mRNA

NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015

G

neuropilin 1

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]

NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844

G

neuropilin 2

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA]

NCBI chr 1:62,742,476...62,857,851
Ensembl chr 1:62,742,444...62,857,854

G

neurexin I

decreases expression

Thalidomide results in decreased expression of NRXN1 mRNA

NCBI chr17:90,341,072...91,400,587
Ensembl chr17:90,341,059...91,400,499

G

5'-nucleotidase, cytosolic III

decreases expression

Thalidomide results in decreased expression of NT5C3 mRNA

NCBI chr 6:56,859,385...56,900,993
Ensembl chr 6:56,859,385...56,900,917

G

5' nucleotidase, ecto

decreases expression

Thalidomide results in decreased expression of NT5E mRNA

NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145

G

N-terminal Asn amidase

decreases expression

Thalidomide results in decreased expression of NTAN1 mRNA

NCBI chr16:13,636,629...13,653,314
Ensembl chr16:13,636,709...13,653,315

G

nudix hydrolase 14

decreases expression

Thalidomide results in decreased expression of NUDT14 mRNA

NCBI chr12:112,897,911...112,905,762
Ensembl chr12:112,897,911...112,905,744

G

nudix hydrolase 22

decreases expression

Thalidomide results in decreased expression of NUDT22 mRNA

NCBI chr19:6,970,387...6,973,471
Ensembl chr19:6,970,386...6,973,485

G

nucleoporin 62 C-terminal like

decreases expression

Thalidomide results in decreased expression of NUP62CL mRNA

NCBI chr X:138,907,551...138,963,456
Ensembl chr X:138,907,554...138,963,461

G

nucleolar and spindle associated protein 1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of NUSAP1 mRNA

NCBI chr 2:119,449,205...119,480,646
Ensembl chr 2:119,448,779...119,481,725

G

2'-5' oligoadenylate synthetase 1G

decreases expression

Thalidomide results in decreased expression of OAS1G mRNA

NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676

G

occludin

multiple interactions

Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of OCLN protein]

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

oligodendrocyte transcription factor 2

increases expression

Thalidomide results in increased expression of OLIG2 mRNA

NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565

G

oligodendrocyte transcription factor 3

increases expression

Thalidomide results in increased expression of OLIG3 mRNA

NCBI chr10:19,232,287...19,234,352
Ensembl chr10:19,232,281...19,234,352

G

olfactory receptor family 10 subfamily Q member 1

increases expression

Thalidomide results in increased expression of OR10Q1 mRNA

NCBI chr19:13,726,472...13,727,419
Ensembl chr19:13,717,092...13,727,843

G

olfactory receptor family 13 subfamily A member 27

increases expression

Thalidomide results in increased expression of OR13A27 mRNA

NCBI chr 7:139,924,965...139,925,900
Ensembl chr 7:139,923,728...139,941,584

G

olfactory receptor family 1 subfamily D member 2

increases expression

Thalidomide results in increased expression of OR1D2 mRNA

NCBI chr11:74,255,497...74,256,435
Ensembl chr11:74,252,895...74,257,044

G

olfactory receptor family 2 subfamily AG member 1

increases expression

Thalidomide results in increased expression of OR2AG1 mRNA

NCBI chr 7:106,472,500...106,473,450
Ensembl chr 7:106,471,077...106,476,098

G

olfactory receptor family 2 subfamily Y member 1

increases expression

Thalidomide results in increased expression of OR2Y1 mRNA

NCBI chr11:49,385,362...49,386,291
Ensembl chr11:49,379,897...49,388,323

G

olfactory receptor family 2 subfamily Y member 15

increases expression

Thalidomide results in increased expression of OR2Y15 mRNA

NCBI chr11:49,350,508...49,351,443
Ensembl chr11:49,346,170...49,354,828

G

olfactory receptor family 51 subfamily Q member 1

increases expression

Thalidomide results in increased expression of OR51Q1 mRNA

NCBI chr 7:103,628,383...103,629,348
Ensembl chr 7:103,620,359...103,636,747

G

olfactory receptor family 51 subfamily Q member 1C

decreases expression

Thalidomide results in decreased expression of OR51Q1C mRNA

NCBI chr 7:103,652,466...103,653,431
Ensembl chr 7:103,647,953...103,653,564

G

olfactory receptor family 52 subfamily S member 1B

increases expression

Thalidomide results in increased expression of OR52S1B mRNA

NCBI chr 7:102,821,898...102,822,842
Ensembl chr 7:102,816,281...102,827,547

G

olfactory receptor family 5 subfamily I member 1

increases expression

Thalidomide results in increased expression of OR5I1 mRNA

NCBI chr 2:87,612,880...87,613,830
Ensembl chr 2:87,609,827...87,614,916

G

olfactory receptor family 5 subfamily P member 80

increases expression

Thalidomide results in increased expression of OR5P80 mRNA

NCBI chr 7:108,229,201...108,230,133
Ensembl chr 7:108,229,201...108,230,835

G

olfactory receptor family 5 subfamily T member 15

increases expression

Thalidomide results in increased expression of OR5T15 mRNA

NCBI chr 2:86,681,114...86,684,664
Ensembl chr 2:86,681,114...86,682,040

G

olfactory receptor family 5 subfamily V member 1B

increases expression

Thalidomide results in increased expression of OR5V1 mRNA

NCBI chr17:37,815,851...37,844,816
Ensembl chr17:37,818,921...37,843,340

G

olfactory receptor family 6 subfamily C member 206

increases expression

Thalidomide results in increased expression of OR6C206 mRNA

NCBI chr10:129,096,832...129,097,770
Ensembl chr10:129,094,996...129,100,167

G

olfactory receptor family 6 subfamily C member 33

decreases expression

Thalidomide results in decreased expression of OR6C33 mRNA

NCBI chr10:129,853,232...129,854,170
Ensembl chr10:129,848,490...129,857,155

G

olfactory receptor family 7 subfamily G member 18

increases expression

Thalidomide results in increased expression of OR7G18 mRNA

NCBI chr 9:18,786,256...18,787,572
Ensembl chr 9:18,785,989...18,789,665

G

olfactory receptor family 8 subfamily A member 1B

decreases expression

Thalidomide results in decreased expression of OR8A1B mRNA

NCBI chr 9:37,622,644...37,623,576
Ensembl chr 9:37,620,260...37,627,546

G

olfactory receptor family 8 subfamily B member 3

increases expression

Thalidomide results in increased expression of OR8B3 mRNA

NCBI chr 9:38,313,007...38,315,125
Ensembl chr 9:38,312,994...38,319,293

G

olfactory receptor family 8 subfamily B member 41

increases expression

Thalidomide results in increased expression of OR8B41 mRNA

NCBI chr 9:38,054,433...38,055,377
Ensembl chr 9:38,053,813...38,059,671

G

olfactory receptor family 8 subfamily G member 18

decreases expression

Thalidomide results in decreased expression of OR8G18 mRNA

NCBI chr 9:39,148,783...39,149,727
Ensembl chr 9:39,145,708...39,161,290

G

olfactory receptor family 9 subfamily K member 2B

increases expression

Thalidomide results in increased expression of OR9K2 mRNA

NCBI chr10:130,015,806...130,016,747
Ensembl chr10:130,014,340...130,020,055

G

osteoclast stimulating factor 1

decreases expression

Thalidomide results in decreased expression of OSTF1 mRNA

NCBI chr19:18,557,728...18,609,177
Ensembl chr19:18,493,501...18,609,187

G

PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

decreases expression

Thalidomide results in decreased expression of PABIR1 mRNA

NCBI chr19:24,451,270...24,454,819
Ensembl chr19:24,453,866...24,454,720

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases cleavage

[Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein
Thalidomide analog results in increased cleavage of PARP1 protein

PMID:15858615 PMID:19372569

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

paired box 3

decreases expression

Thalidomide results in decreased expression of PAX3 mRNA

NCBI chr 1:78,077,904...78,173,773
Ensembl chr 1:78,077,904...78,173,771

G

paired box 6

increases expression

Thalidomide results in increased expression of PAX6 mRNA

NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709

G

programmed cell death 10

decreases expression

Thalidomide results in decreased expression of PDCD10 mRNA

NCBI chr 3:75,423,797...75,464,159
Ensembl chr 3:75,423,797...75,464,163

G

PDZ and LIM domain 3

decreases expression

Thalidomide results in decreased expression of PDLIM3 mRNA

NCBI chr 8:46,338,524...46,372,672
Ensembl chr 8:46,338,498...46,372,585

G

platelet/endothelial cell adhesion molecule 1

decreases expression

Thalidomide results in decreased expression of PECAM1 protein

PMID:18291259 PMID:34520751

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

prefoldin subunit 6

decreases expression

Thalidomide results in decreased expression of PFDN6 mRNA

NCBI chr17:34,157,883...34,159,317
Ensembl chr17:34,157,795...34,159,317

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

multiple interactions

[ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite

NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635

G

paired immunoglobin-like type 2 receptor alpha

decreases expression

Thalidomide results in decreased expression of PILRA mRNA

NCBI chr 5:137,820,214...137,834,540
Ensembl chr 5:137,820,214...137,834,543

G

proviral integration site 1

decreases expression

Thalidomide results in decreased expression of PIM1 protein

NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086

G

plasminogen activator, urokinase

decreases expression

Thalidomide results in decreased expression of PLAU protein

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

plasminogen activator, urokinase receptor

multiple interactions
decreases expression

Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]
Thalidomide results in decreased expression of PLAUR protein

NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393

G

phospholipid transfer protein

decreases expression

Thalidomide results in decreased expression of PLTP mRNA

NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631

G

polymerase (RNA) II (DNA directed) polypeptide K

decreases expression

Thalidomide results in decreased expression of POLR2K mRNA

NCBI chr15:36,174,156...36,177,158
Ensembl chr15:36,174,156...36,177,156

G

popeye domain containing 2

decreases expression

Thalidomide results in decreased expression of POPDC2 mRNA

NCBI chr16:38,182,523...38,198,578
Ensembl chr16:38,182,571...38,198,578

G

peroxisome proliferator activator receptor delta

increases response to substance

PPARD gene SNP results in increased susceptibility to Thalidomide

NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448

G

protein phosphatase 1, regulatory inhibitor subunit 11

decreases expression

Thalidomide results in decreased expression of PPP1R11 mRNA

NCBI chr17:37,259,247...37,262,684
Ensembl chr17:37,259,248...37,262,633

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Thalidomide analog results in increased expression of PPP1R15A mRNA

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein phosphatase 1, regulatory inhibitor subunit 1A

decreases expression

Thalidomide results in decreased expression of PPP1R1A mRNA

NCBI chr15:103,438,706...103,446,465
Ensembl chr15:103,438,706...103,446,430

G

PRELI domain containing 2

decreases expression

Thalidomide results in decreased expression of PRELID2 mRNA

NCBI chr18:42,008,761...42,084,259
Ensembl chr18:42,008,665...42,084,307

G

perforin 1 (pore forming protein)

increases expression

Thalidomide results in increased expression of PRF1

NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459

G

protein kinase C, delta

decreases expression

Thalidomide results in decreased expression of PRKCD mRNA

NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167

G

protein kinase, cGMP-dependent, type I

decreases expression

Thalidomide results in decreased expression of PRKG1 mRNA

NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433

G

proline rich 5 (renal)

decreases expression

Thalidomide results in decreased expression of PRR5 mRNA

NCBI chr15:84,547,407...84,590,610
Ensembl chr15:84,553,821...84,587,874

G

peroxiredoxin like 2A

decreases expression

Thalidomide results in decreased expression of PRXL2A mRNA

NCBI chr14:40,715,692...40,735,790
Ensembl chr14:40,715,697...40,735,745

G

proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

increases expression

Thalidomide results in increased expression of PSME2 mRNA

NCBI chr14:55,824,897...55,828,558
Ensembl chr14:55,824,898...55,828,570

G

phosphatase and tensin homolog

increases expression

Thalidomide results in increased expression of PTEN protein

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 2

increases degradation
decreases expression
multiple interactions
decreases stability

Thalidomide results in increased degradation of PTGS2 protein
Thalidomide results in decreased expression of PTGS2 protein
Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Thalidomide results in decreased stability of PTGS2 mRNA

PMID:11705847 PMID:15982930 PMID:17638016

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RAB2B, member RAS oncogene family

decreases expression

Thalidomide results in decreased expression of RAB2B mRNA

PMID:26006729 PMID:26217789

NCBI chr14:52,499,216...52,516,852
Ensembl chr14:52,499,216...52,517,002

G

RAB8A, member RAS oncogene family

decreases expression

Thalidomide results in decreased expression of RAB8A mRNA

NCBI chr 8:72,915,044...72,935,210
Ensembl chr 8:72,915,044...72,937,748

G

RAS related protein 1b

decreases expression

Thalidomide results in decreased expression of RAP1B mRNA

NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940

G

Ras association (RalGDS/AF-6) domain family (N-terminal) member 9

decreases expression

Thalidomide results in decreased expression of RASSF9 mRNA

NCBI chr10:102,348,083...102,385,598
Ensembl chr10:102,348,083...102,385,597

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
decreases expression

[irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [irinotecan co-treated with Thalidomide] results in increased expression of RELA protein; [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
[Thalidomide co-treated with Dimethylnitrosamine] results in decreased transport of RELA protein; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]
Thalidomide results in decreased expression of RELA protein
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat affects the localization of RELA protein]

PMID:15687330 PMID:16078585 PMID:16333628 PMID:16604421 PMID:16685529 More...

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

avian reticuloendotheliosis viral (v-rel) oncogene related B

increases expression

Thalidomide analog results in increased expression of RELB mRNA

NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363

G

replication factor C (activator 1) 3

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNA

NCBI chr 5:151,566,282...151,574,673
Ensembl chr 5:151,566,221...151,574,707

G

ras homolog family member A

affects expression

Thalidomide affects the expression of RHOA mRNA

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

G

ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)

increases expression

Thalidomide results in increased expression of RNASE2B mRNA

NCBI chr14:51,399,717...51,400,475
Ensembl chr14:51,399,717...51,400,475

G

ribonuclease H2, subunit C

decreases expression

Thalidomide results in decreased expression of RNASEH2C mRNA

NCBI chr19:5,651,901...5,652,987
Ensembl chr19:5,651,901...5,657,047

G

ring finger protein 138

decreases expression

Thalidomide results in decreased expression of RNF138 mRNA

NCBI chr18:21,134,202...21,161,281
Ensembl chr18:21,134,398...21,161,281

G

ring finger protein 166

multiple interactions

Thalidomide results in increased degradation of and results in decreased expression of RNF166 protein

NCBI chr 8:123,192,884...123,202,813
Ensembl chr 8:123,192,886...123,202,803

G

ribosomal protein S15

increases expression

Thalidomide results in increased expression of RPS15 mRNA

NCBI chr10:80,128,265...80,129,948
Ensembl chr10:80,128,287...80,129,948

G

ribosomal protein S6 kinase, polypeptide 2

decreases expression

Thalidomide results in decreased expression of RPS6KA2 mRNA

NCBI chr17:7,356,384...7,570,714
Ensembl chr17:7,292,942...7,570,726

G

related RAS viral (r-ras) oncogene

decreases expression

Thalidomide results in decreased expression of RRAS mRNA

PMID:26006729 PMID:26217789

NCBI chr 7:44,665,686...44,671,070
Ensembl chr 7:44,667,385...44,671,071

G

ribonucleotide reductase M2

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA

NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145

G

reticulon 2 (Z-band associated protein)

decreases expression

Thalidomide results in decreased expression of RTN2 mRNA

NCBI chr 7:19,016,549...19,030,089
Ensembl chr 7:19,016,549...19,030,085

G

ryanodine receptor 2, cardiac

decreases expression

Thalidomide results in decreased expression of RYR2 mRNA

PMID:26006729 PMID:26217789

NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831

G

spalt like transcription factor 4

multiple interactions
increases expression
affects binding

Bortezomib inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; pevonedistat inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; TAK-243 inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein
Thalidomide results in increased expression of SALL4 mRNA
Thalidomide binds to [SALL4 protein binds to CRBN protein]

NCBI chr 2:168,590,252...168,609,121
Ensembl chr 2:168,590,252...168,609,863

G

sin3 associated polypeptide

decreases expression

Thalidomide results in decreased expression of SAP30 mRNA

NCBI chr 8:57,935,740...57,940,874
Ensembl chr 8:57,935,741...57,940,894

G

spermidine/spermine N1-acetyl transferase 1

decreases expression

Thalidomide results in decreased expression of SAT1 mRNA

NCBI chr X:153,996,128...153,999,345
Ensembl chr X:153,996,128...153,999,445

G

sodium channel, voltage-gated, type VII, alpha

decreases expression

Thalidomide results in decreased expression of SCN7A mRNA

NCBI chr 2:66,503,770...66,615,254
Ensembl chr 2:66,503,769...66,615,258

G

succinate dehydrogenase complex assembly factor 1

decreases expression

Thalidomide results in decreased expression of SDHAF1 mRNA

NCBI chr 7:30,020,834...30,021,800
Ensembl chr 7:30,020,831...30,023,320

G

succinate dehydrogenase complex, subunit C, integral membrane protein

decreases expression

Thalidomide results in decreased expression of SDHC mRNA

NCBI chr 1:170,956,726...170,978,209
Ensembl chr 1:170,954,734...170,978,172

G

selenoprotein S

decreases expression

Thalidomide results in decreased expression of SELENOS mRNA

NCBI chr 7:65,729,397...65,739,153
Ensembl chr 7:65,729,397...65,739,153

G

selectin, lymphocyte

decreases expression

Thalidomide results in decreased expression of SELL protein

NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750

G

serine (or cysteine) peptidase inhibitor, clade B, member 2

increases response to substance

SERPINB2 gene SNP results in increased susceptibility to Thalidomide

NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208

G

serine (or cysteine) peptidase inhibitor, clade B, member 6c

increases expression

Thalidomide results in increased expression of SERPINB6C mRNA

NCBI chr13:34,063,799...34,089,709
Ensembl chr13:34,063,799...34,089,691

G

secreted frizzled-related protein 2

increases expression

Thalidomide results in increased expression of SFRP2 mRNA

NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623

G

SH3-binding domain glutamic acid-rich protein

decreases expression

Thalidomide results in decreased expression of SH3BGR mRNA

NCBI chr16:96,001,670...96,030,133
Ensembl chr16:96,001,650...96,030,135

G

solute carrier family 12, member 6

increases response to substance

SLC12A6 gene SNP results in increased susceptibility to Thalidomide

NCBI chr 2:112,096,659...112,193,508
Ensembl chr 2:112,096,170...112,193,508

G

solute carrier family 13 (sodium/sulfate symporters), member 4

decreases expression

Thalidomide results in decreased expression of SLC13A4 mRNA

NCBI chr 6:35,244,888...35,285,061
Ensembl chr 6:35,244,892...35,285,066

G

solute carrier family 22 (organic cation transporter), member 2

multiple interactions

Thalidomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

G

solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20

decreases expression

Thalidomide results in decreased expression of SLC25A20 mRNA

NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840

G

solute carrier family 25, member 30

decreases expression

Thalidomide results in decreased expression of SLC25A30 mRNA

NCBI chr14:75,994,986...76,024,477
Ensembl chr14:75,997,557...76,024,477

G

solute carrier family 2 (facilitated glucose transporter), member 3

increases expression

Thalidomide results in increased expression of SLC2A3 mRNA

NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599

G

solute carrier family 44, member 3

decreases expression

Thalidomide results in decreased expression of SLC44A3 mRNA

NCBI chr 3:121,253,177...121,325,993
Ensembl chr 3:121,253,177...121,326,053

G

solute carrier family 8 (sodium/calcium exchanger), member 1

decreases expression

Thalidomide results in decreased expression of SLC8A1 mRNA

PMID:26006729 PMID:26217789

NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806

G

solute carrier organic anion transporter family, member 4C1

decreases expression

Thalidomide results in decreased expression of SLCO4C1 mRNA

NCBI chr 1:96,744,918...96,800,027
Ensembl chr 1:96,743,995...96,799,896

G

sphingomyelin phosphodiesterase 2, neutral

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein]

NCBI chr10:41,363,168...41,366,410
Ensembl chr10:41,361,638...41,366,365

G

SET and MYND domain containing 1

decreases expression

Thalidomide results in decreased expression of SMYD1 mRNA

PMID:26006729 PMID:26217789

NCBI chr 6:71,190,924...71,239,265
Ensembl chr 6:71,190,924...71,299,217

G

synaptosomal-associated protein 25

increases expression

Thalidomide results in increased expression of SNAP25 mRNA; Thalidomide results in increased expression of SNAP25 protein

NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348

G

small nucleolar RNA, C/D box 104

increases expression

Thalidomide results in increased expression of SNORD104 mRNA

NCBI chr11:106,391,817...106,391,889
Ensembl chr11:106,391,819...106,391,888

G

small nucleolar RNA, C/D box 111

increases expression

Thalidomide results in increased expression of SNORD111 mRNA

NCBI chr 8:111,565,167...111,565,230
Ensembl chr 8:111,565,160...111,565,248

G

small nucleolar RNA, C/D box 123

increases expression

Thalidomide results in increased expression of SNORD123 mRNA

NCBI chr15:32,241,991...32,242,078
Ensembl chr15:32,241,999...32,242,069

G

small nuclear ribonucleoprotein D1

decreases expression

Thalidomide results in decreased expression of SNRPD1 mRNA

NCBI chr18:10,617,796...10,628,230
Ensembl chr18:10,617,775...10,642,079

G

sorting nexin 16

increases expression

Thalidomide analog results in increased expression of SNX16 mRNA

NCBI chr 3:10,482,877...10,505,194
Ensembl chr 3:10,482,877...10,505,162

G

sorting nexing 24

decreases expression

Thalidomide results in decreased expression of SNX24 mRNA

NCBI chr18:53,376,877...53,523,994
Ensembl chr18:53,378,734...53,523,992

G

superoxide dismutase 1, soluble

multiple interactions

Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]

PMID:16510725 PMID:17030452

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

SRY (sex determining region Y)-box 1

decreases expression

Thalidomide results in decreased expression of SOX1 mRNA

NCBI chr 8:12,445,519...12,449,555
Ensembl chr 8:12,445,295...12,450,126

G

SRY (sex determining region Y)-box 17

decreases localization

Thalidomide results in decreased localization of SOX17 protein

NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577

G

trans-acting transcription factor 1

decreases activity

Thalidomide results in decreased activity of SP1 protein

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

trans-acting transcription factor 5

decreases expression

Thalidomide results in decreased expression of SP5 mRNA

NCBI chr 2:70,305,267...70,308,070
Ensembl chr 2:70,305,267...70,308,073

G

sperm autoantigenic protein 17

decreases expression

Thalidomide results in decreased expression of SPA17 mRNA

NCBI chr 9:37,514,590...37,525,018
Ensembl chr 9:37,514,586...37,525,018

G

sperm associated antigen 5

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNA

NCBI chr11:78,192,412...78,213,283
Ensembl chr11:78,192,355...78,213,283

G

SPHK1 interactor, AKAP domain containing

decreases expression

Thalidomide results in decreased expression of SPHKAP mRNA

NCBI chr 1:83,233,163...83,385,853
Ensembl chr 1:83,231,860...83,385,921

G

SRR1 domain containing

decreases expression

Thalidomide results in decreased expression of SRRD mRNA

NCBI chr 5:112,485,257...112,490,921
Ensembl chr 5:112,485,258...112,490,906

G

signal transducer and activator of transcription 3

decreases phosphorylation
multiple interactions

Thalidomide analog results in decreased phosphorylation of STAT3 protein
[resveratrol co-treated with Thalidomide] results in decreased phosphorylation of STAT3 protein; Thalidomide promotes the reaction [Capsaicin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

PMID:15858615 PMID:17164350 PMID:17505005

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

stathmin-like 2

decreases expression

Thalidomide results in decreased expression of STMN2 mRNA

NCBI chr 3:8,574,587...8,626,664
Ensembl chr 3:8,574,420...8,626,666

G

SWIM type zinc finger 7 associated protein 1

decreases expression

Thalidomide results in decreased expression of SWSAP1 mRNA

NCBI chr 9:21,867,049...21,869,566
Ensembl chr 9:21,867,051...21,869,560

G

synaptojanin 2 binding protein

decreases expression

Thalidomide results in decreased expression of SYNJ2BP mRNA

NCBI chr12:81,538,968...81,579,685
Ensembl chr12:81,544,715...81,579,685

G

synaptotagmin XV

decreases expression

Thalidomide results in decreased expression of SYT15 mRNA

NCBI chr14:33,941,915...33,952,378
Ensembl chr14:33,941,552...33,952,377

G

synaptotagmin IV

increases expression

Thalidomide results in increased expression of SYT4 mRNA

NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459

G

tandem C2 domains, nuclear

decreases expression

Thalidomide results in decreased expression of TC2N mRNA

NCBI chr12:101,611,705...101,685,178
Ensembl chr12:101,611,702...101,684,782

G

transcription factor 15

decreases expression

Thalidomide results in decreased expression of TCF15 mRNA

NCBI chr 2:151,984,973...151,991,017
Ensembl chr 2:151,985,481...151,991,017

G

thymine DNA glycosylase

decreases expression

Thalidomide results in decreased expression of TDG mRNA

NCBI chr10:82,465,649...82,486,633
Ensembl chr10:82,465,662...82,486,633

G

transcription elongation factor, mitochondrial

decreases expression

Thalidomide results in decreased expression of TEFM mRNA

NCBI chr11:80,027,500...80,033,697
Ensembl chr11:80,027,504...80,033,001

G

TEK receptor tyrosine kinase

decreases expression

Thalidomide results in decreased expression of TEK mRNA

NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213

G

testis expressed gene 16

decreases expression

Thalidomide results in decreased expression of TEX16 mRNA

NCBI chr  X:110,804,655...111,159,053
Ensembl chr  X:111,148,746...111,153,549
Ensembl chr  X:111,148,746...111,153,549
Ensembl chr  X:111,148,746...111,153,549

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]
Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
Thalidomide results in decreased expression of TGFB1 mRNA; Thalidomide results in decreased expression of TGFB1 protein

PMID:15464241 PMID:16288038 PMID:16510725 PMID:16549389 PMID:16604421 More...

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor, beta induced

decreases expression

Thalidomide results in decreased expression of TGFBI mRNA

PMID:26006729 PMID:26217789

NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375

G

transforming growth factor, beta receptor I

decreases expression

Thalidomide results in decreased expression of TGFBR1 mRNA; Thalidomide results in decreased expression of TGFBR1 protein

NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931

G

tissue inhibitor of metalloproteinase 1

multiple interactions

Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]

PMID:15464241 PMID:17030452

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

multiple interactions

Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

tubulointerstitial nephritis antigen-like 1

decreases expression

Thalidomide results in decreased expression of TINAGL1 mRNA

NCBI chr 4:130,059,393...130,068,915
Ensembl chr 4:130,058,247...130,068,915

G

tight junction protein 1

multiple interactions

Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein]

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

TM2 domain containing 3

decreases expression

Thalidomide results in decreased expression of TM2D3 mRNA

NCBI chr 7:65,343,204...65,351,650
Ensembl chr 7:65,340,917...65,351,661

G

transmembrane protein 138

decreases expression

Thalidomide results in decreased expression of TMEM138 mRNA

NCBI chr19:10,547,842...10,554,765
Ensembl chr19:10,547,842...10,554,726

G

transmembrane protein 176A

decreases expression

Thalidomide results in decreased expression of TMEM176A mRNA

NCBI chr 6:48,818,417...48,822,298
Ensembl chr 6:48,817,853...48,824,005

G

thymopoietin

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA

NCBI chr10:90,983,433...91,017,614
Ensembl chr10:90,983,433...91,017,177

G

tumor necrosis factor

multiple interactions
increases expression
decreases expression
increases degradation

Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Thalidomide inhibits the reaction [lipophosphonoglycan results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]
Thalidomide results in increased expression of TNF protein
Thalidomide results in decreased expression of TNF mRNA
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF protein]
Thalidomide results in increased expression of TNF mRNA
Thalidomide results in increased degradation of TNF mRNA
Thalidomide results in decreased expression of TNF mRNA; Thalidomide results in decreased expression of TNF protein

PMID:9068814 PMID:9623511 PMID:10496904 PMID:10720640 PMID:11367517 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 10b

decreases expression

Thalidomide results in decreased expression of TNFRSF10A protein

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor receptor superfamily, member 1a

decreases expression

Thalidomide results in decreased expression of TNFRSF1A mRNA; Thalidomide results in decreased expression of TNFRSF1A protein

PMID:15618473 PMID:16344495

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

decreases expression

Thalidomide results in decreased expression of TNFRSF1B mRNA

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

tumor necrosis factor (ligand) superfamily, member 10

decreases expression

Thalidomide results in decreased expression of TNFSF10 protein

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

[Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

troponin C, cardiac/slow skeletal

decreases expression

Thalidomide results in decreased expression of TNNC1 mRNA

PMID:26006729 PMID:26217789

NCBI chr14:30,930,274...30,933,671
Ensembl chr14:30,930,269...30,933,686

G

topoisomerase (DNA) II alpha

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

translocation associated membrane protein 1-like 1

decreases expression

Thalidomide results in decreased expression of TRAM1L1 mRNA

NCBI chr 3:124,114,686...124,116,909
Ensembl chr 3:124,114,504...124,118,392

G

trafficking protein particle complex 2L

decreases expression

Thalidomide results in decreased expression of TRAPPC2L mRNA

NCBI chr 8:123,338,365...123,342,330
Ensembl chr 8:123,338,379...123,343,399

G

T cell receptor alpha variable 7-4

decreases expression

Thalidomide results in decreased expression of TRAV7-4 mRNA

NCBI chr14:53,698,666...53,699,195
Ensembl chr14:53,698,556...53,699,195

G

tribbles pseudokinase 3

increases expression

Thalidomide analog results in increased expression of TRIB3 mRNA

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

G

tripartite motif-containing 55

decreases expression

Thalidomide results in decreased expression of TRIM55 mRNA

NCBI chr 3:19,698,591...19,746,748
Ensembl chr 3:19,698,611...19,746,756

G

transformation related protein 53

increases expression

Thalidomide analog results in increased expression of TP53 mRNA

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

tetraspanin 33

decreases expression

Thalidomide results in decreased expression of TSPAN33 mRNA

NCBI chr 6:29,694,213...29,718,557
Ensembl chr 6:29,694,221...29,718,558

G

tetratricopeptide repeat domain 32

decreases expression

Thalidomide results in decreased expression of TTC32 mRNA

NCBI chr12:9,079,997...9,086,394
Ensembl chr12:9,079,997...9,091,988

G

Ttk protein kinase

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA

NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442

G

titin

decreases expression

Thalidomide results in decreased expression of TTN mRNA

PMID:26006729 PMID:26217789

NCBI chr 2:76,534,324...76,812,901
Ensembl chr 2:76,534,324...76,812,891

G

ubiquitin-conjugating enzyme E2C

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of UBE2C mRNA

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

UBX domain protein 1

decreases expression

Thalidomide results in decreased expression of UBXN1 mRNA

NCBI chr19:8,848,912...8,853,030
Ensembl chr19:8,848,860...8,853,227

G

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

decreases expression

Thalidomide results in decreased expression of UCHL3 mRNA

NCBI chr14:101,891,387...101,933,561
Ensembl chr14:101,891,403...101,933,561

G

ubiquitin carboxyl-terminal esterase L4

decreases expression

Thalidomide results in decreased expression of UCHL4 mRNA

NCBI chr 9:64,142,483...64,143,644
Ensembl chr 9:64,142,483...64,143,644

G

UDP glucuronosyltransferase 2 family, polypeptide B37

increases expression

Thalidomide results in increased expression of UGT2B37 mRNA

NCBI chr 5:87,388,351...87,402,647
Ensembl chr 5:87,388,352...87,402,663

G

UNC homeobox

decreases expression

Thalidomide results in decreased expression of UNCX mRNA

NCBI chr 5:139,529,620...139,533,934
Ensembl chr 5:139,529,249...139,533,934

G

uridine phosphorylase 1

decreases expression

Thalidomide results in decreased expression of UPP1 mRNA

NCBI chr11:9,068,008...9,086,170
Ensembl chr11:9,068,103...9,086,170

G

ubiquinol-cytochrome c reductase complex assembly factor 5

decreases expression

Thalidomide results in decreased expression of UQCC5 mRNA

NCBI chr14:30,810,081...30,850,894
Ensembl chr14:30,810,089...30,850,913

G

ubiquitin specific peptidase 17-like E

increases expression

Thalidomide results in increased expression of USP17LE mRNA

NCBI chr 7:104,417,168...104,426,677
Ensembl chr 7:104,417,256...104,426,677

G

vascular cell adhesion molecule 1

decreases expression

Thalidomide results in decreased expression of VCAM1 mRNA; Thalidomide results in decreased expression of VCAM1 protein

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

vascular endothelial growth factor A

affects expression
affects secretion
decreases secretion
decreases activity
decreases expression
increases expression
multiple interactions

Thalidomide affects the expression of VEGFA mRNA; Thalidomide affects the expression of VEGFA protein
Thalidomide affects the secretion of VEGFA protein
Thalidomide analog results in decreased secretion of VEGFA protein
Thalidomide results in decreased activity of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA; Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in increased expression of VEGFA protein
[Thalidomide co-treated with Paclitaxel] results in decreased expression of VEGFA mRNA
[temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA protein
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFA mRNA; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein]; Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein

PMID:15858615 PMID:15863203 PMID:15939924 PMID:15982930 PMID:16313753 More...

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vascular endothelial growth factor B

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFB mRNA
Thalidomide results in decreased expression of VEGFB mRNA

NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019

G

vascular endothelial growth factor C

affects expression

Thalidomide affects the expression of VEGFC mRNA

NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131

G

vascular endothelial growth factor D

decreases expression
multiple interactions

Thalidomide results in decreased expression of VEGFD mRNA
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFD mRNA

NCBI chr X:163,156,282...163,185,643
Ensembl chr X:163,156,374...163,185,646

G

vomeronasal 1 receptor 27

increases expression

Thalidomide results in increased expression of VMN1R27 mRNA

NCBI chr 6:58,192,091...58,193,002
Ensembl chr 6:58,190,076...58,195,806

G

vomeronasal 1 receptor 80

increases expression

Thalidomide results in increased expression of VMN1R80 mRNA

NCBI chr 7:11,926,892...11,927,818
Ensembl chr 7:11,923,213...11,937,240

G

vomeronasal 2, receptor 20

decreases expression

Thalidomide results in decreased expression of VMN2R20 mRNA

NCBI chr 6:123,362,221...123,395,020
Ensembl chr 6:123,350,472...123,395,075

G

vitronectin

decreases expression

Thalidomide results in decreased expression of VTN mRNA

NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150

G

wingless-type MMTV integration site family, member 5B

decreases expression

Thalidomide results in decreased expression of WNT5B mRNA

NCBI chr 6:119,409,493...119,521,847
Ensembl chr 6:119,409,492...119,521,308

G

wingless-type MMTV integration site family, member 8A

decreases expression

Thalidomide results in decreased expression of WNT8A mRNA

NCBI chr18:34,675,380...34,681,114
Ensembl chr18:34,675,366...34,681,326

G

X-linked inhibitor of apoptosis

decreases expression

Thalidomide analog results in decreased expression of XIAP protein

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

X-linked lymphocyte-regulated 3B

increases expression

Thalidomide results in increased expression of XLR3B mRNA

NCBI chr X:72,235,817...72,246,927
Ensembl chr X:72,235,813...72,246,536

G

YJU2 splicing factor homolog B

decreases expression

Thalidomide results in decreased expression of YJU2B mRNA

NCBI chr 8:84,984,396...84,997,087
Ensembl chr 8:84,984,424...84,997,009

G

zinc finger, CCHC domain containing 17

increases expression

Thalidomide results in increased expression of ZCCHC17 mRNA

NCBI chr 4:130,209,176...130,253,785
Ensembl chr 4:130,209,176...130,253,736

G

zinc finger E-box binding homeobox 1

multiple interactions
decreases expression

FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of ZEB1 protein]

NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467

G

zinc finger protein 119b

decreases expression

Thalidomide results in decreased expression of ZFP119B mRNA

NCBI chr17:56,245,373...56,263,186
Ensembl chr17:56,245,381...56,256,500

G

zinc finger protein 273

decreases expression

Thalidomide results in decreased expression of ZFP273 mRNA

NCBI chr13:67,961,935...67,975,119
Ensembl chr13:67,961,859...67,975,121

G

zinc finger protein 692

multiple interactions

Thalidomide results in increased degradation of and results in decreased expression of ZNF692 protein

NCBI chr11:58,197,883...58,205,971
Ensembl chr11:58,197,895...58,205,453

G

zinc finger protein 747

decreases expression

Thalidomide results in decreased expression of ZFP747 mRNA

NCBI chr 7:126,971,709...126,975,222
Ensembl chr 7:126,971,709...126,975,222

G

zinc finger protein 758

decreases expression

Thalidomide results in decreased expression of ZFP758 mRNA

NCBI chr17:22,580,406...22,612,890
Ensembl chr17:22,580,434...22,596,262

G

zinc finger protein 780B

decreases expression

Thalidomide results in decreased expression of ZFP780B mRNA

NCBI chr 7:27,658,560...27,678,768
Ensembl chr 7:27,658,560...27,678,596

G

zinc finger protein 820

decreases expression

Thalidomide results in decreased expression of ZFP820 mRNA

NCBI chr17:22,035,857...22,064,740
Ensembl chr17:22,035,866...22,064,753

G

zinc finger protein 953

decreases expression

Thalidomide results in decreased expression of ZFP953 mRNA

NCBI chr13:67,487,373...67,508,691
Ensembl chr13:67,487,370...67,508,724

G

zinc finger like protein 1

decreases expression

Thalidomide results in decreased expression of ZFPL1 mRNA

NCBI chr19:6,130,792...6,134,961
Ensembl chr19:6,130,792...6,134,986

G

zinc finger, imprinted 1

decreases expression

Thalidomide results in decreased expression of ZIM1 mRNA

NCBI chr 7:6,677,443...6,699,521
Ensembl chr 7:6,674,268...6,699,449

G

zinc finger with KRAB and SCAN domains 5

decreases expression

Thalidomide results in decreased expression of ZKSCAN5 mRNA

NCBI chr 5:145,141,349...145,158,562
Ensembl chr 5:145,141,372...145,158,560

G

zinc finger, matrin type 5

decreases expression

Thalidomide results in decreased expression of ZMAT5 mRNA

NCBI chr11:4,654,671...4,687,669
Ensembl chr11:4,654,678...4,687,669

G

zinc ribbon domain containing 2

decreases expression

Thalidomide results in decreased expression of ZNRD2 mRNA

NCBI chr19:5,780,334...5,781,760
Ensembl chr19:5,780,331...5,781,760
Ensembl chr19:5,780,331...5,781,760

G

zinc finger and SCAN domain containing 12

decreases expression

Thalidomide results in decreased expression of ZSCAN12 mRNA

NCBI chr13:21,546,982...21,556,472
Ensembl chr13:21,546,990...21,556,459

pomalidomide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bromodomain containing 4

multiple interactions

pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]

NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696

G

caspase 3

multiple interactions

[afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions

[afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

C-C motif chemokine ligand 2

increases secretion

pomalidomide results in increased secretion of CCL2 protein

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

CCAAT/enhancer binding protein alpha

increases expression

pomalidomide results in increased expression of CEBPA mRNA

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

CCAAT/enhancer binding protein delta

increases expression

pomalidomide results in increased expression of CEBPD mRNA

NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895

G

CCAAT/enhancer binding protein epsilon

increases expression

pomalidomide results in increased expression of CEBPE mRNA

NCBI chr14:54,947,823...54,949,604
Ensembl chr14:54,947,817...54,949,631

G

cereblon

multiple interactions
affects binding
increases response to substance

[pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide

PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223

NCBI chr 6:106,755,205...106,777,060
Ensembl chr 6:106,757,162...106,777,038

G

colony stimulating factor 2 (granulocyte-macrophage)

decreases secretion

pomalidomide results in decreased secretion of CSF2 protein

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

colony stimulating factor 3 (granulocyte)

increases secretion

pomalidomide results in increased secretion of CSF3 protein

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

cytochrome P450, family 2, subfamily c, polypeptide 38

increases oxidation

CYP2C19 protein results in increased oxidation of pomalidomide

NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519

G

cytochrome P450, family 2, subfamily j, polypeptide 9

increases oxidation

CYP2J2 protein results in increased oxidation of pomalidomide

NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815

G

DTW domain containing 1

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein

NCBI chr 2:125,993,981...126,007,197
Ensembl chr 2:125,994,061...126,007,199

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702

G

family with sequence similarity 83, member F

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein

NCBI chr15:80,555,829...80,584,626
Ensembl chr15:80,556,048...80,584,626

G

fibroblast growth factor receptor 1

decreases expression

pomalidomide results in decreased expression of FGFR1 mRNA

NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734

G

fibroblast growth factor receptor 3

affects expression

pomalidomide affects the expression of FGFR3 mRNA

NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412

G

forkhead box O1

multiple interactions

[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein]

NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642

G

GATA binding protein 1

decreases expression

pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein

NCBI chr X:7,825,504...7,842,844
Ensembl chr X:7,825,499...7,844,310

G

GATA binding protein 2

decreases expression

pomalidomide results in decreased expression of GATA2 mRNA

NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014

G

growth factor independent 1 transcription repressor

increases expression

pomalidomide results in increased expression of GFI1 mRNA

NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902

G

growth factor independent 1B

decreases expression

pomalidomide results in decreased expression of GFI1B mRNA

NCBI chr 2:28,499,462...28,511,994
Ensembl chr 2:28,499,462...28,511,994

G

inhibitor of DNA binding 1, HLH protein

increases expression

pomalidomide results in increased expression of ID1 mRNA

NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330

G

inhibitor of DNA binding 2

increases expression

pomalidomide results in increased expression of ID2 mRNA

NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139

G

IKAROS family zinc finger 1

multiple interactions

[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein]

NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926

G

IKAROS family zinc finger 3

multiple interactions

[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein]

NCBI chr11:98,355,436...98,437,157
Ensembl chr11:98,355,728...98,436,857

G

interleukin 10

increases secretion

pomalidomide results in increased secretion of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 13

decreases secretion

pomalidomide results in decreased secretion of IL13 protein

NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529

G

interleukin 2

multiple interactions

Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 5

decreases secretion

pomalidomide results in decreased secretion of IL5 protein

NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933

G

interferon regulatory factor 4

multiple interactions

[pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein

NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959

G

jun D proto-oncogene

decreases expression

pomalidomide results in decreased expression of JUND mRNA

NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265

G

Kruppel-like transcription factor 1 (erythroid)

decreases expression

pomalidomide results in decreased expression of KLF1 mRNA

NCBI chr 8:85,628,611...85,631,920
Ensembl chr 8:85,628,557...85,631,924

G

LIM domain only 2

decreases expression

pomalidomide results in decreased expression of LMO2 mRNA

NCBI chr 2:103,788,309...103,812,223
Ensembl chr 2:103,788,331...103,812,223

G

Meis homeobox 2

multiple interactions

pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]

NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320

G

nuclear factor, erythroid derived 2

decreases expression

pomalidomide results in decreased expression of NFE2 mRNA

NCBI chr15:103,156,640...103,166,809
Ensembl chr15:103,156,639...103,166,830

G

protein kinase C, theta

multiple interactions

pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein]

NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033

G

RAB28, member RAS oncogene family

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein

NCBI chr 5:41,782,316...41,865,535
Ensembl chr 5:41,782,319...41,865,500

G

spalt like transcription factor 4

multiple interactions
affects binding

pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein
pomalidomide binds to [SALL4 protein binds to CRBN protein]

NCBI chr 2:168,590,252...168,609,121
Ensembl chr 2:168,590,252...168,609,863

G

Spi-1 proto-oncogene

increases expression
decreases expression

pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein

PMID:15292067 PMID:16373662

NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101

G

widely-interspaced zinc finger motifs

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of WIZ protein

NCBI chr17:32,573,021...32,608,463
Ensembl chr17:32,573,029...32,608,413

G

zinc finger and BTB domain containing 39

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein

NCBI chr10:127,575,399...127,583,218
Ensembl chr10:127,575,407...127,583,218

G

zinc finger protein 653

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein

NCBI chr 9:21,966,705...21,982,707
Ensembl chr 9:21,966,707...21,982,672

G

zinc finger protein 91

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein

NCBI chr19:12,744,303...12,773,487
Ensembl chr19:12,744,384...12,773,490

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22205
role	22190
application	21776
anti-inflammatory agent	17361
anti-inflammatory drug	15224
thalidomide	529
5-(2,2-diferuloylethen-1-yl)thalidomide	0
5-[2-(feruloyl)ethen-1-yl]thalidomide	0
pomalidomide	44
Path 2
Term	Annotations
CHEBI ontology	22205
subatomic particle	22197
composite particle	22197
hadron	22197
baryon	22197
nucleon	22169
atomic nucleus	22197
atom	22197
main group element atom	22131
p-block element atom	22131
carbon group element atom	21928
carbon atom	21854
organic molecular entity	21854
organic molecule	21671
organic cyclic compound	21276
organic heterocyclic compound	20346
organic heteropolycyclic compound	19637
organic heterobicyclic compound	18208
benzopyrrole	9716
isoindoles	1243
phthalimides	1099
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione	529
(R)-thalidomide	529
thalidomide	529
5-(2,2-diferuloylethen-1-yl)thalidomide	0
5-[2-(feruloyl)ethen-1-yl]thalidomide	0
pomalidomide	44

paths to the root