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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of ANGPT2 mRNA | CTD | PMID:15598610 | 17beta-estradiol | multiple interactions | ISO | RGD:730844 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of ANGPT2 mRNA | CTD | PMID:17404688 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ANGPT2 mRNA | CTD | PMID:21570461 | 2,4,6-trinitrotoluene | affects expression | ISO | RGD:621861 | 6480464 | Trinitrotoluene affects the expression of ANGPT2 mRNA | CTD | PMID:21346803 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of ANGPT2 mRNA | CTD | PMID:18648102 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:730844 | 6480464 | decitabine results in increased expression of ANGPT2 mRNA | CTD | PMID:21856257 | 5-fluorouracil | decreases expression | ISO | RGD:730844 | 6480464 | Fluorouracil results in decreased expression of ANGPT2 protein | CTD | PMID:17786339 | 5-fluorouracil | multiple interactions | ISO | RGD:730844 | 6480464 | ANGPT2 protein promotes the reaction [Fluorouracil results in decreased expression of IFNA1 protein] | CTD | PMID:17786339 | all-trans-retinoic acid | increases expression | ISO | RGD:730844 | 6480464 | Tretinoin results in increased expression of ANGPT2 protein | CTD | PMID:18922099 | all-trans-retinoic acid | increases expression | ISO | RGD:730844 | 6480464 | Tretinoin results in increased expression of ANGPT2 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | increases secretion | ISO | RGD:730844 | 6480464 | Tretinoin results in increased secretion of ANGPT2 protein | CTD | PMID:17170094 | ammonium chloride | affects expression | ISO | RGD:621861 | 6480464 | Ammonium Chloride affects the expression of ANGPT2 mRNA | CTD | PMID:16483693 | astemizole | increases expression | ISO | RGD:621861 | 6480464 | Astemizole results in increased expression of ANGPT2 mRNA | CTD | PMID:20221588 | benzo[a]pyrene | increases expression | ISO | RGD:730844 | 6480464 | Benzo(a)pyrene results in increased expression of ANGPT2 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of ANGPT2 mRNA | CTD | PMID:22228805 PMID:22610609 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of ANGPT2 mRNA | CTD | PMID:22228805 | calcitriol | increases expression | ISO | RGD:730844 | 6480464 | Calcitriol results in increased expression of ANGPT2 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:730844 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of ANGPT2 mRNA | CTD | PMID:21592394 | capsaicin | increases expression | ISO | RGD:730844 | 6480464 | Capsaicin results in increased expression of ANGPT2 mRNA | CTD | PMID:21310942 | cobalt dichloride | decreases expression | ISO | RGD:730844 | 6480464 | cobaltous chloride results in decreased expression of ANGPT2 mRNA | CTD | PMID:19320972 | copper atom | decreases expression | ISO | RGD:730844 | 6480464 | Copper results in decreased expression of ANGPT2 mRNA | CTD | PMID:19747488 | copper(0) | decreases expression | ISO | RGD:730844 | 6480464 | Copper results in decreased expression of ANGPT2 mRNA | CTD | PMID:19747488 | copper(2+) sulfate | affects expression | ISO | RGD:730844 | 6480464 | Copper Sulfate affects the expression of ANGPT2 mRNA | CTD | PMID:19549813 | daunorubicin | increases expression | ISO | RGD:621861 | 6480464 | Daunorubicin results in increased expression of ANGPT2 mRNA; more ... | CTD | PMID:16626513 | diarsenic trioxide | increases expression | ISO | RGD:730844 | 6480464 | arsenic trioxide results in increased expression of ANGPT2 mRNA | CTD | PMID:20458559 | diazoxide | increases expression | ISO | RGD:621861 | 6480464 | Isoproterenol results in increased expression of ANGPT2 mRNA | CTD | PMID:22908232 | dioxygen | increases expression | ISO | RGD:730844 | 6480464 | Oxygen deficiency results in increased expression of ANGPT2 mRNA | CTD | PMID:10854229 | dioxygen | increases expression | ISO | RGD:621861 | 6480464 | Oxygen deficiency results in increased expression of ANGPT2 mRNA | CTD | PMID:10854229 | enalapril | multiple interactions | ISO | RGD:621861 | 6480464 | Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] | CTD | PMID:19958114 | furosemide | affects expression | ISO | RGD:621861 | 6480464 | Furosemide affects the expression of ANGPT2 mRNA | CTD | PMID:16526316 | iloprost | increases expression | ISO | RGD:730844 | 6480464 | Iloprost results in increased expression of ANGPT2 mRNA | CTD | PMID:16373414 | iloprost | multiple interactions | ISO | RGD:730844 | 6480464 | tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA] | CTD | PMID:16373414 | isoprenaline | increases expression | ISO | RGD:621861 | 6480464 | Isoproterenol results in increased expression of ANGPT2 mRNA | CTD | PMID:22908232 | mercaptopurine | increases expression | ISO | RGD:621861 | 6480464 | 6-Mercaptopurine results in increased expression of ANGPT2 mRNA | CTD | PMID:23358152 | N-nitrosodiethylamine | increases expression | ISO | RGD:621861 | 6480464 | Diethylnitrosamine results in increased expression of ANGPT2 mRNA | CTD | PMID:17034775 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:621861 | 6480464 | Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT2 mRNA] | CTD | PMID:17034775 | nicotinic acid | decreases expression | EXP | | 6480464 | Niacin results in decreased expression of ANGPT2 mRNA | CTD | PMID:17557352 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of ANGPT2 mRNA | CTD | PMID:17562736 | PD123319 | multiple interactions | ISO | RGD:621861 | 6480464 | PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] | CTD | PMID:14638905 | pioglitazone | multiple interactions | EXP | | 6480464 | [ANGPT2 protein binds to and results in increased activity of AGTR2 protein] promotes the reaction [pioglitazone binds to and results in increased activity of PPARG protein] | CTD | PMID:15992368 | progesterone | multiple interactions | ISO | RGD:730844 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of ANGPT2 mRNA | CTD | PMID:17404688 | purine-6-thiol | increases expression | ISO | RGD:621861 | 6480464 | 6-Mercaptopurine results in increased expression of ANGPT2 mRNA | CTD | PMID:23358152 | simvastatin | multiple interactions | ISO | RGD:621861 | 6480464 | Simvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein] | CTD | PMID:20821229 | streptozocin | increases expression | ISO | RGD:621861 | 6480464 | Streptozocin results in increased expression of ANGPT2 mRNA; more ... | CTD | PMID:15643138 | streptozocin | increases expression | ISO | RGD:621861 | 6480464 | Streptozocin results in increased expression of ANGPT2 mRNA | CTD | PMID:19958114 PMID:15643138 | streptozocin | increases expression | ISO | RGD:621861 | 6480464 | Streptozocin results in increased expression of ANGPT2 protein | CTD | PMID:20821229 PMID:15643138 | streptozocin | increases expression | ISO | RGD:621861 | 6480464 | Streptozocin results in increased expression of ANGPT2 protein | CTD | PMID:15643138 PMID:20821229 | streptozocin | increases expression | ISO | RGD:621861 | 6480464 | Streptozocin results in increased expression of ANGPT2 mRNA | CTD | PMID:15643138 PMID:19958114 | streptozocin | multiple interactions | ISO | RGD:621861 | 6480464 | Simvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein] | CTD | PMID:20821229 | streptozocin | multiple interactions | ISO | RGD:621861 | 6480464 | Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] | CTD | PMID:19958114 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANGPT2 mRNA | CTD | PMID:21641980 | testosterone | multiple interactions | ISO | RGD:730844 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of ANGPT2 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | RGD:730844 | 6480464 | Testosterone results in increased expression of ANGPT2 mRNA | CTD | PMID:21592394 | tetrachloromethane | increases expression | ISO | RGD:621861 | 6480464 | Carbon Tetrachloride results in increased expression of ANGPT2 mRNA; more ... | CTD | PMID:15135347 | tetrathiomolybdate(2-) | increases expression | ISO | RGD:730844 | 6480464 | tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA | CTD | PMID:19323979 | thalidomide | affects expression | ISO | RGD:730844 | 6480464 | Thalidomide affects the expression of ANGPT2 mRNA | CTD | PMID:15939924 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of ANGPT2 mRNA | CTD | PMID:17569031 | troglitazone | multiple interactions | EXP | | 6480464 | [Urethane co-treated with troglitazone] results in increased expression of ANGPT2 mRNA | CTD | PMID:18465119 | urethane | multiple interactions | EXP | | 6480464 | [Urethane co-treated with troglitazone] results in increased expression of ANGPT2 mRNA | CTD | PMID:18465119 | valsartan | multiple interactions | ISO | RGD:621861 | 6480464 | valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] | CTD | PMID:14638905 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | HIF-1 signaling pathway |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling (PID:200079) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | HIF-1 signaling pathway |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling (PID:200079) |
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Rizkalla B, etal., J Hypertens. 2005 Jan;23(1):153-64. |
| 25. |
Ryu JK, etal., Urology. 2006 Jun;67(6):1329-34. |
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Saito M, etal., Pathol Int. 2007 Mar;57(3):140-7. |
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Shyu KG, etal., Clin Sci (Lond). 2003 Sep;105(3):287-94. |
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Tiani C, etal., J Hepatol. 2009 Feb;50(2):296-305. Epub 2008 Dec 4. |
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Tilki D, etal., Cancer. 2007 Nov 15;110(10):2347-62. |
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Tipps RS, etal., J Thorac Cardiovasc Surg. 2008 Aug;136(2):283-9. |
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Wen CY, etal., J Gastroenterol. 2003;38(5):431-5. |
| 34. |
Yuan J, etal., Pediatr Nephrol. 2009 Jan;24(1):163-70. Epub 2008 Aug 28. |
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RGD Disease Portals| Angpt2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Angpt2 (Mus musculus) |
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| ANGPT2 (Homo sapiens) |
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| Angpt2 (Rattus norvegicus) |
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Position Markers| Angpt2 |
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| UniSTS:235845 |
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| D8Ertd51e |
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| PMC314347P1 |
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| Angpt2 |
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| Angpt2 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_007426 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01068287 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01068288 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC122206 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC129567 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF004326 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK019860 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK048622 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK143974 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK156132 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK186615 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC027216 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC138309 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC138313 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466566 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CJ182273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN539462 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_007426 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_031452 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_031452 | (Get FASTA) |
| GenBank Protein | AAB63189 | (Get FASTA) |
| AAH27216 | (Get FASTA) | |
| AAI38310 | (Get FASTA) | |
| AAI38314 | (Get FASTA) | |
| BAB31887 | (Get FASTA) | |
| BAC33396 | (Get FASTA) | |
| BAE33599 | (Get FASTA) | |
| EDL22217 | (Get FASTA) | |
| O35608 | (Get FASTA) |
Promoters| RGD ID: | 6848253 | ||||||||||
| Promoter ID: | MM_ACW:46980 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_0Hour | ||||||||||
| Transcripts: | ANGPT2.BSEP07, ANGPT2.DSEP07-UNSPLICED | ||||||||||
| Position: |
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| RGD ID: | 6842758 | ||||||||||
| Promoter ID: | MM_KWN:53776 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain | ||||||||||
| Transcripts: | ENSMUST00000033846 | ||||||||||
| Position: |
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| RGD ID: | 6881972 | ||||||||||
| Promoter ID: | EPDNEW_M4437 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Angpt2_1 | ||||||||||
| Description: | angiopoietin 2 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000031465 | |
| Entrez Gene | 11601 | ENTREZGENE |
| Gene3D-CATH | Fibrinogen_a/b/g_C_1 | UniProtKB/Swiss-Prot |
| Fibrinogen_a/b/g_C_2 | UniProtKB/Swiss-Prot | |
| Germonline | ENSMUSG00000031465 | |
| HomoloGene Group ID | 22401 | ENTREZGENE |
| InterPro | Fibrinogen_a/b/g_C | UniProtKB/Swiss-Prot |
| Fibrinogen_a/b/g_C_1 | UniProtKB/Swiss-Prot | |
| Fibrinogen_a/b/g_C_2 | UniProtKB/Swiss-Prot | |
| Fibrinogen_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:11601 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1202890 | ENTREZGENE |
| Pfam | Fibrinogen_C | UniProtKB/Swiss-Prot |
| PROSITE | FIBRINOGEN_C_1 | UniProtKB/Swiss-Prot |
| FIBRINOGEN_C_2 | UniProtKB/Swiss-Prot | |
| SMART | FBG | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Fibrinogen_a/b/g_C | UniProtKB/Swiss-Prot |
| UniGene | Mm.439874 | ENTREZGENE |
| UniProt | ANGP2_MOUSE | UniProtKB/Swiss-Prot |
| B9EHQ4_MOUSE | UniProtKB/TrEMBL |
| More on Angpt2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1550503 |
| Created: | 2005-09-30 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.