Rnase2b (ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)) - Rat Genome Database

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Gene: Rnase2b (ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)) Mus musculus
Analyze
No known orthologs.
Symbol: Rnase2b
Name: ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)
RGD ID: 1617574
MGI Page MGI
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to several human genes including RNASE2 (ribonuclease A family member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ea; Ear5; eosinophil cationic-type ribonuclease 5; eosinophil-associated ribonuclease 5; eosinophil-associated, ribonuclease A family, member 5; MGC143624; mR; MR-5; mR5; murine ribonuclease 5; Raf4; ribonuclease 2B; ribonuclease A f4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,399,717 - 51,400,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,399,717 - 51,400,475 (+)EnsemblGRCm39 Ensembl
GRCm381451,162,260 - 51,163,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,162,260 - 51,163,018 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,781,935 - 51,782,693 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,084,415 - 50,084,882 (+)NCBIMGSCv36mm8
Celera1447,456,274 - 47,457,032 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8901588   PMID:9336452   PMID:10594173   PMID:12466851   PMID:12477932   PMID:15058383   PMID:15676279   PMID:21267068   PMID:21873635   PMID:24005575   PMID:24337645   PMID:27765572  


Genomics

Variants

.
Variants in Rnase2b
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:165
Interacting mature miRNAs:172
Transcripts:ENSMUST00000075648
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142310Carg1_mCandida albicans resistance gene 1 (mouse)Not determined5138245954461655Mouse

Markers in Region
UniSTS:490507  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381451,162,464 - 51,162,931UniSTSGRCm38
MGSCv371451,782,139 - 51,782,606UniSTSGRCm37
Celera1447,456,478 - 47,456,945UniSTS
Cytogenetic Map14C1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000075648   ⟹   ENSMUSP00000075074
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,399,717 - 51,400,475 (+)Ensembl
GRCm38.p6 Ensembl1451,162,260 - 51,163,018 (+)Ensembl
RefSeq Acc Id: NM_019398   ⟹   NP_062271
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,399,717 - 51,400,475 (+)NCBI
GRCm381451,162,260 - 51,163,018 (+)ENTREZGENE
MGSCv371451,781,935 - 51,782,693 (+)RGD
Celera1447,456,274 - 47,457,032 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062271   ⟸   NM_019398
- Peptide Label: precursor
- UniProtKB: Q8K416 (UniProtKB/Swiss-Prot),   O35292 (UniProtKB/Swiss-Prot),   W0UVC5 (UniProtKB/TrEMBL),   Q0VDV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000075074   ⟸   ENSMUST00000075648
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35292-F1-model_v2 AlphaFold O35292 1-155 view protein structure

Promoters
RGD ID:8682154
Promoter ID:EPDNEW_M19108
Type:single initiation site
Name:Rnase2b_1
Description:Mus musculus ribonuclease, RNase A family, 2B (liver, eosinophil-derivedneurotoxin) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381451,162,239 - 51,162,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858598 AgrOrtholog
Ensembl Genes ENSMUSG00000059606 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000075648 ENTREZGENE
  ENSMUST00000075648.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858598 ENTREZGENE
NCBI Gene 54159 ENTREZGENE
PANTHER EOSINOPHIL-ASSOCIATED, RIBONUCLEASE A FAMILY, MEMBER 11-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RNASE3 RGD
PhenoGen Rnase2b PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RNASE_PANCREATIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O35292 ENTREZGENE
  Q0VDV3 ENTREZGENE, UniProtKB/TrEMBL
  Q8K416 ENTREZGENE
  RNS2B_MOUSE UniProtKB/Swiss-Prot
  W0UVC5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8K416 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-22 Rnase2b  ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)  Ear5  eosinophil-associated, ribonuclease A family, member 5  Symbol and/or name change 5135510 APPROVED