Adam4 (a disintegrin and metallopeptidase domain 4) - Rat Genome Database

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Gene: Adam4 (a disintegrin and metallopeptidase domain 4) Mus musculus
Analyze
No known orthologs.
Symbol: Adam4
Name: a disintegrin and metallopeptidase domain 4
RGD ID: 1551977
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Is expressed in glossopharyngeal ganglion and trigeminal ganglion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metalloprotease domain (ADAM) 4; a disintegrin and metalloprotease domain 4; AV274654; tMDC; tMDCV
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Gm5746  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,466,217 - 81,468,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,466,217 - 81,468,720 (-)EnsemblGRCm39 Ensembl
GRCm381281,419,443 - 81,422,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,419,443 - 81,421,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,520,536 - 82,522,865 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,338,397 - 82,340,726 (-)NCBIMGSCv36mm8
Celera1282,884,918 - 82,887,247 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Cho C, etal., Genomics 1996 Jun 15;34(3):413-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7750654   PMID:8163572   PMID:8889548   PMID:9441766   PMID:10349636   PMID:10657254   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11486040   PMID:11842132   PMID:12477932  
PMID:15028286   PMID:16141072   PMID:16141073   PMID:16208538   PMID:19129510   PMID:21267068   PMID:21873635  


Genomics

Variants

.
Variants in Adam4
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSMUST00000085319
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301868Fbgl1_mfasting blood glucose 1 (mouse)Not determined127904016483162211Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
AV274654  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381281,419,535 - 81,419,655UniSTSGRCm38
MGSCv371282,520,522 - 82,520,642UniSTSGRCm37
Celera1282,884,904 - 82,885,024UniSTS
Cytogenetic Map12D1UniSTS
Whitehead/MRC_RH12757.96UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000085319   ⟹   ENSMUSP00000082427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1281,466,217 - 81,468,720 (-)Ensembl
GRCm38.p6 Ensembl1281,419,443 - 81,421,946 (-)Ensembl
RefSeq Acc Id: NM_009620   ⟹   NP_033750
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391281,466,217 - 81,468,813 (-)NCBI
GRCm381281,419,443 - 81,422,039 (-)NCBI
MGSCv371282,520,536 - 82,522,865 (-)RGD
Celera1282,884,918 - 82,887,247 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033750 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA74922 (Get FASTA)   NCBI Sequence Viewer  
  AAI50160 (Get FASTA)   NCBI Sequence Viewer  
  AAI50482 (Get FASTA)   NCBI Sequence Viewer  
  AAN77877 (Get FASTA)   NCBI Sequence Viewer  
  EDL02714 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000082427
  ENSMUSP00000082427.4
Reference Protein Sequences
RefSeq Acc Id: NP_033750   ⟸   NM_009620
- Peptide Label: precursor
- UniProtKB: Q8CGQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000082427   ⟸   ENSMUST00000085319
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGQ2-F1-model_v2 AlphaFold Q8CGQ2 1-763 view protein structure

Promoters
RGD ID:6822663
Promoter ID:MM_KWN:12087
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4
Transcripts:NM_009620
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361282,520,566 - 82,521,066 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104731 AgrOrtholog
Ensembl Genes ENSMUSG00000072972 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085319 ENTREZGENE
  ENSMUST00000085319.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report mmu:11498 UniProtKB/TrEMBL
MGD MGI:104731 ENTREZGENE
NCBI Gene 11498 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF167 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam4 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt Q60815_MOUSE UniProtKB/TrEMBL
  Q8CGQ2 ENTREZGENE, UniProtKB/TrEMBL