Defa3 (defensin, alpha, 3) - Rat Genome Database

Name: Defa3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Defa3 (defensin, alpha, 3) Mus musculus

Analyze

Symbol:

Defa3

Name:

defensin, alpha, 3

RGD ID:

1622404

MGI Page

MGI

Description:

Predicted to enable pore-forming activity and protein homodimerization activity. Acts upstream of or within response to bacterium and response to xenobiotic stimulus. Located in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA5 (defensin alpha 5).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alpha-defensin 3; Defa27; Defcr; Defcr-; Defcr-3; Defcr3; defensin, alpha, 27; defensin-related cryptdin-3

RGD Orthologs

Human

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DEFA3 (defensin alpha 3)	HGNC	Ensembl, OMA, OrthoDB, Panther, Treefam
Other homologs ²
Homo sapiens (human):	DEFA5 (defensin alpha 5)	HGNC	Ensembl, OrthoMCL, Panther
Homo sapiens (human):	DEFA6 (defensin alpha 6)	HGNC	Ensembl, Panther, Treefam
Homo sapiens (human):	DEFA1 (defensin alpha 1)	HGNC	Ensembl, Panther, Treefam
Homo sapiens (human):	DEFA4 (defensin alpha 4)	HGNC	Ensembl, Panther, Treefam
Homo sapiens (human):	DEFA1B (defensin alpha 1B)	HGNC	Ensembl, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Defa24 (defensin alpha 24)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	DEFA6 (defensin alpha 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA3 (defensin alpha 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA5 (defensin alpha 5)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA1 (defensin alpha 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA1B (defensin alpha 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	21,777,425 - 21,778,393 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	21,777,425 - 21,778,393 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	21,287,409 - 21,288,377 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	21,287,409 - 21,288,377 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	22,427,088 - 22,428,056 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	22,782,195 - 22,783,035 (+)	NCBI		MGSCv36	mm8
Celera	8	20,702,827 - 20,703,795 (+)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	10.35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute promyelocytic leukemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

chlorothalonil (EXP)

chromium(6+) (EXP)

ciguatoxin CTX1B (EXP)

diarsenic trioxide (ISO)

disodium selenite (ISO)

enilconazole (EXP)

iron atom (ISO)

iron(0) (ISO)

mifepristone (ISO)

procymidone (EXP)

progesterone (ISO)

thalidomide (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial humoral response (IBA)

antimicrobial humoral immune response mediated by antimicrobial peptide (IBA)

cellular response to lipopolysaccharide (IBA,IGI)

defense response to bacterium (IDA)

defense response to Gram-negative bacterium (IBA,IGI)

defense response to Gram-positive bacterium (IBA,IGI)

disruption of plasma membrane integrity in another organism (IBA)

innate immune response in mucosa (IBA)

intracellular estrogen receptor signaling pathway (ISO)

response to xenobiotic stimulus (IDA)

Cellular Component

extracellular space (IBA,IDA,ISO)

intracellular membrane-bounded organelle (ISO)

midbody (ISO)

secretory granule (ISO)

Molecular Function

pore-forming activity (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1500431	PMID:7927786	PMID:8188287	PMID:10725249	PMID:10922068	PMID:10922379	PMID:11248802	PMID:11733520	PMID:11960772	PMID:12477932	PMID:18186922	PMID:20003482
PMID:21873635	PMID:30718392

Genomics

Comparative Map Data

Defa3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	21,777,425 - 21,778,393 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	21,777,425 - 21,778,393 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	21,287,409 - 21,288,377 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	21,287,409 - 21,288,377 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	22,427,088 - 22,428,056 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	22,782,195 - 22,783,035 (+)	NCBI		MGSCv36	mm8
Celera	8	20,702,827 - 20,703,795 (+)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	10.35	NCBI

DEFA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	7,015,869 - 7,018,297 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	7,015,869 - 7,018,297 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	6,873,391 - 6,875,819 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	6,860,805 - 6,863,226 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	6,860,804 - 6,863,226	NCBI
Cytogenetic Map	8	p23.1	NCBI
HuRef	8	6,614,645 - 6,617,074 (-)	NCBI		HuRef
CHM1_1	8	6,961,928 - 6,964,357 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	6,770,536 - 6,772,968 (-)	NCBI		T2T-CHM13v2.0

Variants

Variants in Defa3
25 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	135
Count of miRNA genes:	128
Interacting mature miRNAs:	131
Transcripts:	ENSMUST00000098893
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13432571	Scvg1_m	subcutaneous vessel growth QTL 1 (mouse)					8	1	24751082	Mouse
11533914	Mts5_m	mammary tumor susceptibility 5 (mouse)					8	1	30447432	Mouse
4140978	Nilac5_m	nicotine induced locomotor activity 5 (mouse)			Not determined		8	1	31773288	Mouse
27226756	Femd2_m	femur midshaft diameter 2, 5 week (mouse)					8	4950000	35067154	Mouse
1357525	Pnhdlc3_m	plasma non-HDL cholesterol 3 (mouse)			Not determined		8	7212499	23753815	Mouse
1301532	Scc8_m	colon tumor susceptibility 8 (mouse)			Not determined		8	7212499	35110107	Mouse
1300906	Ap8q_m	alcohol preference 8 QTL (mouse)			Not determined		8	7984189	41984342	Mouse
10412209	Cypr7_m	cytokine production 7 (mouse)			Not determined		8	8103201	42103372	Mouse
1301929	Eae24_m	susceptibility to experimental allergic encephalomyelitis 24 (mouse)			Not determined		8	8103201	42103372	Mouse
1301128	Sluc20_m	susceptibility to lung cancer 20 (mouse)			Not determined		8	8103201	42103372	Mouse
11532713	Sluc42_m	susceptibility to lung cancer 42 (mouse)					8	13447210	35321225	Mouse
1558870	Eae36_m	experimental allergic encephalomyelitis susceptibility 36 (mouse)			Not determined		8	14773160	71498244	Mouse
1301088	Alcw6_m	alcohol withdrawal 6 (mouse)			Not determined		8	15506572	49506729	Mouse
1300912	Daq19_m	directional asymmetry QTL 19 (mouse)			Not determined		8	15506572	49506729	Mouse
1301298	Pgia4_m	proteoglycan induced arthritis 4 (mouse)			Not determined		8	16569373	50569697	Mouse
4142199	Poats1_m	post-ovarectomy adrenal tumor susceptibility 1 (mouse)			Not determined			17082626	28849467	Mouse
1301550	Fembrs2_m	femur breaking strength 2 (mouse)			Not determined		8	18321097	52321225	Mouse
1301160	Eae14_m	susceptibility to experimental allergic encephalomyelitis 14 (mouse)			Not determined		8	19455018	53455150	Mouse
1300603	Cd8ts2_m	CD8 T cell subset 2 (mouse)			Not determined		8	19455018	53455150	Mouse

Markers in Region

Defcr3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	8	A2	UniSTS
cM Map	8		UniSTS

Defcr17

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
MGSCv37	8	22,728,705 - 22,729,408	UniSTS	GRCm37
MGSCv37	8	22,389,491 - 22,390,194	UniSTS	GRCm37
Celera	8	21,017,916 - 21,018,626	UniSTS
Cytogenetic Map	8	A2	UniSTS
cM Map	8		UniSTS

AU014719

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	8	A2	UniSTS
Whitehead/MRC_RH	8	238.28	UniSTS

UniSTS:489047

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	21,287,443 - 21,288,283	UniSTS	GRCm38
GRCm38	8	21,655,801 - 21,656,641	UniSTS	GRCm38
MGSCv37	8	22,427,122 - 22,427,962	UniSTS	GRCm37
MGSCv37	8	22,766,273 - 22,767,113	UniSTS	GRCm37
Celera	8	21,076,688 - 21,077,518	UniSTS
Cytogenetic Map	8	A2	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_007850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH005400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S73391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U03030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000098893 ⟹ ENSMUSP00000096492

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	21,777,425 - 21,778,393 (+)	Ensembl
GRCm38.p6 Ensembl	8	21,287,409 - 21,288,377 (+)	Ensembl

RefSeq Acc Id:

NM_007850 ⟹ NP_031876

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	21,777,425 - 21,778,393 (+)	NCBI
GRCm38	8	21,287,409 - 21,288,377 (+)	ENTREZGENE
MGSCv37	8	22,427,088 - 22,428,056 (+)	RGD
Celera	8	20,702,827 - 20,703,795 (+)	NCBI
cM Map	8		ENTREZGENE

Sequence:

show sequence

TCCTGCTCACCAATCCTCCAGGTGACTCCCAGCCATGAAGACACTAGTCCTCCTCTCTGCCCTC
GTCCTGCTGGCCTTCCAGGTCCAGGCTGATCCTATCCAAAACACAGATGAAGAGACTAAAACTG
AGGAGCAGCCAGGGGAAGACGACCAGGCTGTGTCTGTCTCTTTTGGAGACCCAGAAGGCTCTTC
TCTTCAAGAGGAATCGTTGAGAGATCTGGTATGCTATTGTAGAAAAAGAGGCTGCAAAAGAAGA
GAACGCATGAATGGGACCTGCAGAAAGGGTCATTTAATGTACACACTCTGCTGTCGCTGAACAT
GGAGACCACAGAGGACAAGACGAACATGAGTACTGAGGCCACTGATGCTGGTGCCTGATGACTA
CCTCGCAATAAATTGTTCGCAATATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_031876	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA20972	(Get FASTA)	NCBI Sequence Viewer
	AAA57171	(Get FASTA)	NCBI Sequence Viewer
	AAB32271	(Get FASTA)	NCBI Sequence Viewer
	AAB60677	(Get FASTA)	NCBI Sequence Viewer
	AAH99854	(Get FASTA)	NCBI Sequence Viewer
	AAH99855	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000078485.6
	ENSMUSP00000096492
	ENSMUSP00000096492.4
GenBank Protein	P28310	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_031876 ⟸ NM_007850
- Peptide Label:	precursor
- UniProtKB:	P50708 (UniProtKB/Swiss-Prot), P50705 (UniProtKB/Swiss-Prot), Q499K7 (UniProtKB/Swiss-Prot), P28310 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MKTLVLLSALVLLAFQVQADPIQNTDEETKTEEQPGEDDQAVSVSFGDPEGSSLQEESLRDLVC YCRKRGCKRRERMNGTCRKGHLMYTLCCR hide sequence

RefSeq Acc Id:

ENSMUSP00000096492 ⟸ ENSMUST00000098893

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P28310-F1-model_v2	AlphaFold	P28310	1-93	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:94883	AgrOrtholog
Ensembl Genes	ENSMUSG00000060208	UniProtKB/Swiss-Prot
	ENSMUSG00000074440	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000079528.6	UniProtKB/Swiss-Prot
	ENSMUST00000098893	ENTREZGENE
	ENSMUST00000098893.4	UniProtKB/Swiss-Prot
InterPro	Alpha-defensin	UniProtKB/Swiss-Prot
	Alpha-defensin_pro	UniProtKB/Swiss-Prot
	Defensin_beta/alpha	UniProtKB/Swiss-Prot
	Defensin_propep	UniProtKB/Swiss-Prot
KEGG Report	mmu:13237	UniProtKB/Swiss-Prot
	mmu:23855	UniProtKB/Swiss-Prot
MGD	MGI:94883	ENTREZGENE
NCBI Gene	13237	ENTREZGENE
PANTHER	ALPHA-DEFENSIN 1-RELATED	UniProtKB/Swiss-Prot
	PTHR11876	UniProtKB/Swiss-Prot
Pfam	Defensin_1	UniProtKB/Swiss-Prot
	Defensin_propep	UniProtKB/Swiss-Prot
PhenoGen	Defa3	PhenoGen
PIRSF	Alpha-defensin	UniProtKB/Swiss-Prot
PROSITE	DEFENSIN	UniProtKB/Swiss-Prot
SMART	Defensin_propep	UniProtKB/Swiss-Prot
	DEFSN	UniProtKB/Swiss-Prot
Superfamily-SCOP	Defensin-like	UniProtKB/Swiss-Prot
UniProt	DEFA3_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	P50705	ENTREZGENE
	P50708	ENTREZGENE
	Q499K7	ENTREZGENE
UniProt Secondary	Q499K7	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD