Top2a (topoisomerase (DNA) II alpha) - Rat Genome Database

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Gene: Top2a (topoisomerase (DNA) II alpha) Mus musculus
Analyze
Symbol: Top2a
Name: topoisomerase (DNA) II alpha
RGD ID: 62340
MGI Page MGI
Description: Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including chromosome organization; embryonic cleavage; and positive regulation of transcription by RNA polymerase II. Located in chromosome and nucleus. Is active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, alpha isozyme; Top; Top-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm5362  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,883,773 - 98,915,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,883,769 - 98,915,015 (-)EnsemblGRCm39 Ensembl
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBIMGSCv36mm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (EXP,ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-diaminotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
9,10-phenanthroquinone  (ISO)
9-hydroxyellipticine  (ISO)
acetamide  (ISO)
acetamiprid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
altenusin  (ISO)
alternariol  (ISO)
Altertoxin I  (ISO)
Altertoxin II  (ISO)
amsacrine  (ISO)
anthracenes  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
aurofusarin  (ISO)
azathioprine  (ISO)
barium sulfate  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Boswellic acid  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captafol  (EXP)
captan  (EXP)
Carbadox  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
cefaloridine  (ISO)
CGP 52608  (ISO)
chlorendic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cryptotanshinone  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
deguelin  (ISO)
delphinidin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
diquat  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
ethylbenzene  (ISO)
etoposide  (EXP,ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (EXP)
Heliotrine  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
hypericin  (ISO)
ifosfamide  (ISO)
indirubin  (ISO)
indole-3-methanol  (ISO)
irinotecan  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (EXP)
lucanthone  (ISO)
Macrosporin  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mycotoxin  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene-1,2-diol  (ISO)
nevadensin  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
Nitidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oleanolic acid  (ISO)
oxaliplatin  (ISO)
oxfendazole  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pectolinarigenin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin B2  (ISO)
progesterone  (ISO)
promethazine  (ISO)
propanal  (ISO)
propiconazole  (EXP)
Pyrenophorol  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
razoxane  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Stemphyltoxin III  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
tremolite asbestos  (EXP)
triacsin C  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (EXP)
ursolic acid  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
Xanthatin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy. Albadine R, etal., J Urol. 2009 Aug;182(2):735-40. Epub 2009 Jun 18.
2. DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity. Berney DM, etal., BJU Int. 2008 Sep;102(8):1040-4. Epub 2008 May 16.
3. Prognostic markers of low-grade squamous intraepithelial lesions: the role of topoisomerase IIalpha and active caspase-3. Coelho RA, etal., Eur J Gynaecol Oncol. 2008;29(5):499-501.
4. Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Faggad A, etal., Mod Pathol. 2009 Apr;22(4):579-88. Epub 2009 Mar 6.
5. Clinical Implications and Prognostic Values of Topoisomerase-II Alpha Expression in Primary Non-Muscle-Invasive Bladder Cancer. Kim EJ, etal., Urology. 2009 Nov 12.
6. Identification of prognostic biomarkers for prostate cancer. Kosari F, etal., Clin Cancer Res. 2008 Mar 15;14(6):1734-43.
7. Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy. Martin CM, etal., Methods Mol Biol. 2009;511:333-59.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D. Nielsen KV, etal., Acta Oncol. 2008;47(4):725-34.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. Rochette L, etal., Trends Pharmacol Sci. 2015 Jun;36(6):326-48. doi: 10.1016/j.tips.2015.03.005. Epub 2015 Apr 17.
16. Topoisomerase IIalpha expression in ductal carcinoma in situ of the breast: a preliminary study. Shpitz B, etal., Hum Pathol. 2000 Oct;31(10):1249-54.
17. Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer. Sparano JA, etal., Clin Cancer Res. 2009 Dec 15;15(24):7693-7700. Epub .
18. Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features. Takahashi M, etal., Cancer Res. 2002 Nov 15;62(22):6598-605.
19. Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression. Tretiakova M, etal., J Clin Pathol. 2006 Dec;59(12):1272-7. Epub 2006 Mar 23.
20. Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts. Usha L, etal., J Hematol Oncol. 2008 Aug 14;1:12.
Additional References at PubMed
PMID:1331984   PMID:1380833   PMID:1683482   PMID:2555055   PMID:7671812   PMID:7842491   PMID:7937150   PMID:8241259   PMID:8261398   PMID:8389625   PMID:8884812   PMID:9020022  
PMID:9040785   PMID:9094096   PMID:9224616   PMID:9714832   PMID:10207078   PMID:10349636   PMID:10922068   PMID:10942766   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11835579  
PMID:11835580   PMID:11940566   PMID:12149265   PMID:12439594   PMID:12477932   PMID:12520002   PMID:12653966   PMID:12859955   PMID:12904583   PMID:14610273   PMID:14681479   PMID:16091739  
PMID:16107646   PMID:16141072   PMID:16141073   PMID:16611985   PMID:17011187   PMID:17362930   PMID:17578914   PMID:17998154   PMID:18032420   PMID:18394993   PMID:18451150   PMID:18799693  
PMID:19521500   PMID:19936747   PMID:20362542   PMID:21327095   PMID:21589869   PMID:21677750   PMID:21795393   PMID:21862448   PMID:21873635   PMID:22111588   PMID:22308494   PMID:23086144  
PMID:23144714   PMID:23466610   PMID:23505375   PMID:23698369   PMID:24013524   PMID:24029230   PMID:24048577   PMID:24072229   PMID:24154525   PMID:24321095   PMID:24586484   PMID:24741061  
PMID:25036735   PMID:25043184   PMID:25451918   PMID:25737280   PMID:25961503   PMID:26167872   PMID:26657567   PMID:26816005   PMID:26919979   PMID:27404349   PMID:27558965   PMID:27750031  
PMID:28250416   PMID:28302748   PMID:28323137   PMID:28378742   PMID:28535371   PMID:28611047   PMID:29445148   PMID:30196744   PMID:30228104   PMID:30457570   PMID:30635555   PMID:31598710  
PMID:31839538   PMID:32060399   PMID:32325033   PMID:32469866   PMID:32640236   PMID:32758484   PMID:34174788   PMID:34851661   PMID:34880220   PMID:35012549   PMID:35449600   PMID:36029179  
PMID:36114006   PMID:36633090   PMID:38060382   PMID:38445610  


Genomics

Comparative Map Data
Top2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,883,773 - 98,915,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,883,769 - 98,915,015 (-)EnsemblGRCm39 Ensembl
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBIMGSCv36mm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.91NCBI
TOP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,388,525 - 40,417,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,388,525 - 40,417,896 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,544,777 - 38,574,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,798,321 - 35,827,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341735,798,320 - 35,827,695NCBI
Celera1735,204,916 - 35,234,352 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,337,633 - 34,367,123 (-)NCBIHuRef
CHM1_11738,780,085 - 38,809,522 (-)NCBICHM1_1
T2T-CHM13v2.01741,252,019 - 41,281,395 (-)NCBIT2T-CHM13v2.0
Top2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,441,954 - 84,473,093 (-)NCBIGRCr8
mRatBN7.21083,945,731 - 83,976,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,889,659 - 88,920,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,387,764 - 88,418,905 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,780,312 - 83,811,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Celera1082,687,594 - 82,716,976 (-)NCBICelera
Cytogenetic Map10q31NCBI
Top2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,929,136 - 14,964,723 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,928,273 - 14,964,855 (-)NCBIChiLan1.0ChiLan1.0
TOP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,537,882 - 24,567,338 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,432,885 - 26,462,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,872,169 - 16,901,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,097,619 - 17,127,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,097,778 - 17,126,207 (+)Ensemblpanpan1.1panPan2
TOP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,207,501 - 22,237,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,207,638 - 22,237,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,679,941 - 21,709,943 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,000,244 - 23,030,254 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,000,269 - 23,029,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,774,298 - 21,804,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,033,150 - 22,063,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,157,897 - 22,187,909 (+)NCBIUU_Cfam_GSD_1.0
Top2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,608,163 - 21,633,139 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,441,575 - 15,466,978 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,441,463 - 15,465,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,001,282 - 22,028,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,001,300 - 22,028,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,310,214 - 22,337,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,761,391 - 65,792,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,761,416 - 65,792,701 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,662,555 - 36,693,082 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Top2a
1029 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:568
Count of miRNA genes:390
Interacting mature miRNAs:454
Transcripts:ENSMUST00000068031, ENSMUST00000129777, ENSMUST00000139460, ENSMUST00000139730, ENSMUST00000144318, ENSMUST00000151997, ENSMUST00000154332
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse

Markers in Region
Top2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1157.0UniSTS
PMC207566P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381199,006,004 - 99,007,011UniSTSGRCm38
MGSCv371198,867,318 - 98,868,325UniSTSGRCm37
Celera11108,671,803 - 108,672,809UniSTS
Cytogenetic Map11DUniSTS
cM Map1157.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006533155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000068031   ⟹   ENSMUSP00000068896
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,883,769 - 98,915,015 (-)Ensembl
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129777
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,912,911 - 98,915,004 (-)Ensembl
GRCm38.p6 Ensembl1199,022,085 - 99,024,178 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139460
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,884,293 - 98,886,196 (-)Ensembl
GRCm38.p6 Ensembl1198,993,467 - 98,995,370 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,907,419 - 98,913,036 (-)Ensembl
GRCm38.p6 Ensembl1199,016,593 - 99,022,210 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,894,451 - 98,897,348 (-)Ensembl
GRCm38.p6 Ensembl1199,003,625 - 99,006,522 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,890,773 - 98,892,086 (-)Ensembl
GRCm38.p6 Ensembl1198,999,947 - 99,001,260 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154332
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,883,897 - 98,886,550 (-)Ensembl
GRCm38.p6 Ensembl1198,993,071 - 98,995,724 (-)Ensembl
RefSeq Acc Id: NM_011623   ⟹   NP_035753
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,883,773 - 98,915,015 (-)NCBI
GRCm381198,992,947 - 99,024,189 (-)NCBI
MGSCv371198,854,261 - 98,885,503 (-)RGD
Celera11108,658,802 - 108,690,006 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006533153   ⟹   XP_006533216
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,883,773 - 98,915,037 (-)NCBI
GRCm381198,992,947 - 99,024,199 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006533154   ⟹   XP_006533217
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,883,776 - 98,915,037 (-)NCBI
GRCm381198,992,947 - 99,024,199 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006533155   ⟹   XP_006533218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,883,773 - 98,915,037 (-)NCBI
GRCm381198,992,947 - 99,024,199 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035753   ⟸   NM_011623
- UniProtKB: E9PX08 (UniProtKB/Swiss-Prot),   Q01320 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006533218   ⟸   XM_006533155
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006533217   ⟸   XM_006533154
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006533216   ⟸   XM_006533153
- Peptide Label: isoform X1
- UniProtKB: E9PX08 (UniProtKB/Swiss-Prot),   Q01320 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000068896   ⟸   ENSMUST00000068031
Protein Domains
DNA topoisomerase type IIA   DNA topoisomerase type IIA subunit B   DTHCT   Histidine kinase/HSP90-like ATPase   Topo IIA-type catalytic   Toprim

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01320-F1-model_v2 AlphaFold Q01320 1-1528 view protein structure

Promoters
RGD ID:6822376
Promoter ID:MM_KWN:9637
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000014727,   OTTMUST00000014729
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,885,196 - 98,885,697 (-)MPROMDB
RGD ID:8676544
Promoter ID:EPDNEW_M16302
Type:initiation region
Name:Top2a_1
Description:Mus musculus topoisomerase II alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381199,024,190 - 99,024,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98790 AgrOrtholog
Ensembl Genes ENSMUSG00000020914 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000068031 ENTREZGENE
  ENSMUST00000068031.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.268.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1360.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.30 UniProtKB/Swiss-Prot
  3.30.230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.199.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DTHCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_A/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_A/C_ab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_A_a_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_bsu_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoII_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoIIA_CS UniProtKB/Swiss-Prot
  TOPRIM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_TopoII UniProtKB/Swiss-Prot
KEGG Report mmu:21973 UniProtKB/Swiss-Prot
MGD MGI:98790 ENTREZGENE
NCBI Gene 21973 ENTREZGENE
PANTHER DNA TOPOISOMERASE 2-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA TOPOISOMERASE/GYRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DNA_gyraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_topoisoIV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTHCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toprim UniProtKB/Swiss-Prot
  TOPRIM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TOP2A RGD
PhenoGen Top2a PhenoGen
PRINTS TOPISMRASEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPI2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TOPO_IIA UniProtKB/Swiss-Prot
  TOPOISOMERASE_II UniProtKB/Swiss-Prot
  TOPRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TOP2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOP4c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PX08 ENTREZGENE
  Q01320 ENTREZGENE
  Q3TTG4_MOUSE UniProtKB/TrEMBL
  Q3UUS6_MOUSE UniProtKB/TrEMBL
  Q52KI5_MOUSE UniProtKB/TrEMBL
  Q6PET9_MOUSE UniProtKB/TrEMBL
  Q8CCE5_MOUSE UniProtKB/TrEMBL
  TOP2A_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9PX08 UniProtKB/Swiss-Prot