Biological Process
| angiogenesis | | IMP | MGI:MGI:2159357 | 2290270 | MGI:MGI:1315113|PMID:9846489 | MGI | MGI:MGI:1315113 PMID:9846489 |
| angiogenesis | | IMP | | 2290270 | MGI:MGI:74274|PMID:7596437 | UniProtKB | MGI:MGI:74274 PMID:7596437 |
| angiogenesis | | TAS | | 2290270 | MGI:MGI:4943617|PMID:20299672 | DFLAT | MGI:MGI:4943617 PMID:20299672 |
| cell-cell adhesion | | IMP | MGI:MGI:2159358 | 2290270 | MGI:MGI:2387759|PMID:9683559 | MGI | MGI:MGI:2387759 PMID:9683559 |
| cell-matrix adhesion | | IMP | MGI:MGI:2159358 | 2290270 | MGI:MGI:2387759|PMID:9683559 | MGI | MGI:MGI:2387759 PMID:9683559 |
| endothelial cell proliferation | | IMP | | 2290270 | MGI:MGI:68132|PMID:7958865 | UniProtKB | MGI:MGI:68132 PMID:7958865 |
| heart development | | IMP | | 2290270 | MGI:MGI:68132|PMID:7958865 | UniProtKB | MGI:MGI:68132 PMID:7958865 |
| heart trabecula formation | | IMP | | 2290270 | MGI:MGI:68132|PMID:7958865 | UniProtKB | MGI:MGI:68132 PMID:7958865 |
| hemopoiesis | | IMP | | 2290270 | MGI:MGI:3051189|PMID:15260986 | MGI | MGI:MGI:3051189 PMID:15260986 |
| hemopoiesis | | IMP | MGI:MGI:2159357 | 2290270 | MGI:MGI:1315113|PMID:9846489 | MGI | MGI:MGI:1315113 PMID:9846489 |
| intracellular signal transduction | | ISO | NCBI:NP_001099207 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| negative regulation of angiogenesis | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| negative regulation of apoptotic process | | IGI | MGI:MGI:108448 | 2290270 | MGI:MGI:3848848|PMID:19409199 | MGI | MGI:MGI:3848848 PMID:19409199 |
| negative regulation of endothelial cell apoptotic process | | IMP | | 2290270 | MGI:MGI:3691072|PMID:11375937 | UniProtKB | MGI:MGI:3691072 PMID:11375937 |
| patterning of blood vessels | | TAS | | 2290270 | MGI:MGI:4943617|PMID:20299672 | DFLAT | MGI:MGI:4943617 PMID:20299672 |
| peptidyl-tyrosine phosphorylation | | IDA | | 2290270 | MGI:MGI:68132|PMID:7958865 | UniProtKB | MGI:MGI:68132 PMID:7958865 |
| peptidyl-tyrosine phosphorylation | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| phosphorylation | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| positive regulation of actin cytoskeleton reorganization | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of angiogenesis | | ISO | NCBI:NP_001099207 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| positive regulation of angiogenesis | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of cell adhesion | | IMP | | 2290270 | MGI:MGI:3051189|PMID:15260986 | MGI | MGI:MGI:3051189 PMID:15260986 |
| positive regulation of endothelial cell migration | | TAS | | 2290270 | MGI:MGI:4830635|PMID:20406889 | DFLAT | MGI:MGI:4830635 PMID:20406889 |
| positive regulation of endothelial cell migration | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of endothelial cell migration | | TAS | | 2290270 | MGI:MGI:4943617|PMID:20299672 | DFLAT | MGI:MGI:4943617 PMID:20299672 |
| positive regulation of ERK1 and ERK2 cascade | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of focal adhesion assembly | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of intracellular protein kinase cascade | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of peptidyl-serine phosphorylation | | IGI | MGI:MGI:108448 | 2290270 | MGI:MGI:3848848|PMID:19409199 | MGI | MGI:MGI:3848848 PMID:19409199 |
| positive regulation of phosphatidylinositol 3-kinase activity | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of phosphatidylinositol 3-kinase cascade | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of protein kinase B signaling cascade | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of protein phosphorylation | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | | TAS | | 2290270 | MGI:MGI:4830635|PMID:20406889 | DFLAT | MGI:MGI:4830635 PMID:20406889 |
| protein autophosphorylation | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| protein oligomerization | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| protein phosphorylation | | IEA | InterPro:IPR000719|InterPro:IPR001245|InterPro:IPR018941|InterPro:IPR008266|InterPro:IPR020635 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| regulation of angiogenesis | | IMP | MGI:MGI:2159358 | 2290270 | MGI:MGI:2387759|PMID:9683559 | MGI | MGI:MGI:2387759 PMID:9683559 |
| regulation of cell migration | | IMP | MGI:MGI:2159358 | 2290270 | MGI:MGI:2387759|PMID:9683559 | MGI | MGI:MGI:2387759 PMID:9683559 |
| regulation of endothelial cell proliferation | | TAS | | 2290270 | MGI:MGI:4830635|PMID:20406889 | DFLAT | MGI:MGI:4830635 PMID:20406889 |
| regulation of establishment or maintenance of cell polarity | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| response to estrogen stimulus | | ISO | NCBI:NP_001099207 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| response to retinoic acid | | IDA | | 2290270 | MGI:MGI:3799604|PMID:18439490 | BHF-UCL | MGI:MGI:3799604 PMID:18439490 |
| sprouting angiogenesis | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| substrate adhesion-dependent cell spreading | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| Tie signaling pathway | | TAS | | 2290270 | MGI:MGI:4943617|PMID:20299672 | DFLAT | MGI:MGI:4943617 PMID:20299672 |
| Tie signaling pathway | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| transmembrane receptor protein tyrosine kinase signaling pathway | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| vasculogenesis | | IMP | | 2290270 | MGI:MGI:68132|PMID:7958865 | UniProtKB | MGI:MGI:68132 PMID:7958865 |
Cellular Component
| apical plasma membrane | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| basal plasma membrane | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| basolateral plasma membrane | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| cell junction | | IEA | UniProtKB-KW:KW-0965 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| cell surface | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| cell-cell junction | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| cytoplasm | | IEA | UniProtKB-KW:KW-0963 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| cytoskeleton | | IEA | UniProtKB-KW:KW-0206 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| extracellular region | | IEA | UniProtKB-KW:KW-0964 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| integral to membrane | | ISM | | 2290270 | MGI:MGI:63311|PMID:8415706 | MGI | MGI:MGI:63311 PMID:8415706 |
| integral to plasma membrane | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| membrane | | IEA | UniProtKB-KW:KW-0472 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| membrane raft | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| microvillus | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| plasma membrane | | IEA | UniProtKB-KW:KW-1003 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
Molecular Function
| ATP binding | | IEA | InterPro:IPR000719|InterPro:IPR017441|InterPro:IPR018941 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| ATP binding | | IEA | UniProtKB-KW:KW-0067 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| growth factor binding | | ISO | NCBI:NP_001099207 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| kinase activity | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| nucleotide binding | | IEA | UniProtKB-KW:KW-0547 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| protein binding | | IPI | UniProtKB:O35608 | 2290270 | MGI:MGI:1202254|PMID:9204896 | MGI | MGI:MGI:1202254 PMID:9204896 |
| protein binding | | IPI | UniProtKB:B2RU80 | 2290270 | MGI:MGI:4412467|PMID:10557082 | UniProtKB | MGI:MGI:4412467 PMID:10557082 |
| protein kinase activity | | IEA | InterPro:IPR000719|InterPro:IPR001245 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| protein tyrosine kinase activity | | IDA | | 2290270 | MGI:MGI:68132|PMID:7958865 | UniProtKB | MGI:MGI:68132 PMID:7958865 |
| protein tyrosine kinase activity | | ISO | UniProtKB:Q02763 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| receptor activity | | IPI | UniProtKB:O08538 | 2290270 | MGI:MGI:84853|PMID:8980223 | MGI | MGI:MGI:84853 PMID:8980223 |
| transferase activity | | IEA | UniProtKB-KW:KW-0808 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| transferase activity, transferring phosphorus-containing groups | | IEA | InterPro:IPR011009 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| transmembrane receptor protein tyrosine kinase activity | | IEA | EC:2.7.10.1 | 2290270 | MGI:MGI:2152096 | UniProtKB | MGI:MGI:2152096 |
| transmembrane receptor protein tyrosine kinase activity | | IEA | InterPro:IPR018941 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| 1558948 | Ath8_m | atherosclerosis 8 (mouse) | | | Not determined | | 4 | 45671314 | 104972403 | Mouse |
| 1357486 | Bmch2_m | bone mechanical trait 2 (mouse) | | | Not determined | | 4 | 45722797 | 102244445 | Mouse |
| 1357895 | Ctrcts_m | cataract severity (mouse) | | | Not determined | | 4 | 45722797 | 138171357 | Mouse |
| 4141900 | Skts-fp1_m | skin tumor susceptibility in FVB and PWK 1 (mouse) | | | Not determined | | 4 | 53563711 | 123838630 | Mouse |
| 4141746 | Vms3_m | viral myocarditis susceptibility locus 3 (mouse) | | | Not determined | | 4 | 63347193 | 97347352 | Mouse |
| 1357870 | Pfat1_m | predicted fat percentage 1 (mouse) | | | Not determined | | 4 | 63347193 | 97347352 | Mouse |
| 1300697 | Sle2_m | systemic lupus erythmatosus susceptibility 2 (mouse) | | | Not determined | | 4 | 65636691 | 99636827 | Mouse |
| 1301757 | Tlsr4_m | thymic lymphoma suppressor region 4 (mouse) | | | Not determined | | 4 | 66484797 | 100484925 | Mouse |
| 1357561 | Mbsyd_m | metabolic syndrome (mouse) | | | Not determined | | 4 | 66616112 | 100616255 | Mouse |
| 1302057 | Pgia27_m | proteoglycan induced arthritis 27 (mouse) | | | Not determined | | 4 | 69794894 | 103795131 | Mouse |
| 1301739 | Pitm2_m | prion incubation time 2 (mouse) | | | Not determined | | 4 | 71709736 | 105709883 | Mouse |
| 1302044 | Nss1_m | NOD Sjogren's syndrome 1 (mouse) | | | Not determined | | 4 | 71709736 | 105709883 | Mouse |
| 1300966 | Pabr2_m | plasma apolipoprotein B (human) regulator 2 (mouse) | | | Not determined | | 4 | 71709736 | 105709883 | Mouse |
| 1300817 | Orgwq6_m | organ weight QTL 6 (mouse) | | | Not determined | | 4 | 71709736 | 105709883 | Mouse |
| 1302031 | Bulb1_m | bulb size 1 (mouse) | | | Not determined | | 4 | 73812341 | 107812483 | Mouse |
| 1301597 | Anxty_m | anxiety (mouse) | | | Not determined | | 4 | 73865241 | 127792731 | Mouse |
| 1302116 | Bbaa1_m | B.burgdorferi-associated arthritis 1 (mouse) | | | Not determined | | 4 | 77072064 | 111072194 | Mouse |
| 4141716 | Bmgr4_m | bone marrow graft rejection 4 (mouse) | | | Not determined | | 4 | 77072064 | 111072194 | Mouse |
| 1300601 | Tlsr1_m | thymic lymphoma suppressor region 1 (mouse) | | | Not determined | | 4 | 79409453 | 113409664 | Mouse |
| 1302204 | Spm1_m | splenomegaly modifier (mouse) | | | Not determined | | 4 | 82022849 | 116023036 | Mouse |
| 1300548 | Adaz1_m | anti-dsDNA antibody production in NZM 1 (mouse) | | | Not determined | | 4 | 83072102 | 117072212 | Mouse |
| 1357546 | Vtbt3_m | vertebral trabecular bone trait 3 (mouse) | | | Not determined | | 4 | 83423186 | 117423312 | Mouse |
| 4141087 | Chlq4_m | circulating hormone level QTL 4 (mouse) | | | Not determined | | 4 | 85244246 | 119244445 | Mouse |
| 1357491 | Fmgty3_m | femur geometry 3 (mouse) | | | Not determined | | 4 | 85244246 | 119244445 | Mouse |
| 1357726 | Lnopy1_m | lens opacity 1 (mouse) | | | Not determined | | 4 | 85244246 | 119244445 | Mouse |
| 1301556 | Cd4vts1_m | CD4 virgin T cell subset 1 (mouse) | | | Not determined | | 4 | 85244246 | 119244445 | Mouse |
| 1301930 | Papg1_m | pulmonary adenoma progression 1 (mouse) | | | Not determined | | 4 | 85596575 | 119596687 | Mouse |
| 1301118 | Bbaa23_m | B.burgdorferi-associated arthritis 23 (mouse) | | | Not determined | | 4 | 85596575 | 119596687 | Mouse |
| 4141629 | Psds1_m | psoriasis-like skin disease severity 1 (mouse) | | | Not determined | | 4 | 86096047 | 100423312 | Mouse |
| 1301823 | Bmd7_m | bone mineral density 7 (mouse) | | | Not determined | | 4 | 88709736 | 150944202 | Mouse |
| 1357890 | Hpcr1_m | hepatocarcinogen resistance 1 (mouse) | | | Not determined | | 4 | 89785035 | 123785155 | Mouse |
| 1300918 | Stheal4_m | soft tissue heal 4 (mouse) | | | Not determined | | 4 | 89785035 | 123785155 | Mouse |
| 1558833 | Erars2_m | erosive arthritis susceptibility 2 (mouse) | | | Not determined | | 4 | 92473540 | 126473664 | Mouse |