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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
increases expression |
EXP |
Nifedipine results in increased expression of ABCB1 protein |
CTD |
PMID:8632764 |
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NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ABCB11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
EXP |
Nifedipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Nifedipine results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
Nifedipine results in increased expression of ABCC2 mRNA |
CTD |
PMID:12206135 |
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NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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G |
ABCC3 |
ATP binding cassette subfamily C member 3 |
increases activity multiple interactions increases expression |
EXP |
Nifedipine results in increased activity of ABCC3 protein [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA Nifedipine results in increased expression of ABCC3 mRNA |
CTD |
PMID:14570758 |
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NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
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G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases expression multiple interactions |
EXP |
Nifedipine results in decreased expression of AKT1 protein modified form 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]] |
CTD |
PMID:20530298 PMID:20562903 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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G |
APOA1 |
apolipoprotein A1 |
increases expression |
EXP |
Nifedipine results in increased expression of APOA1 |
CTD |
PMID:1928808 |
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NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
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G |
APOA2 |
apolipoprotein A2 |
increases expression |
EXP |
Nifedipine results in increased expression of APOA2 |
CTD |
PMID:1928808 |
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NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
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G |
AVP |
arginine vasopressin |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium] |
CTD |
PMID:14711191 |
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NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
Nifedipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Nifedipine inhibits the reaction [Iohexol results in increased expression of BAX protein] Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA] |
CTD |
PMID:19698708 PMID:24349043 PMID:36207783 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2 |
BCL2 apoptosis regulator |
decreases expression multiple interactions |
EXP ISO |
Nifedipine results in decreased expression of BCL2 Nifedipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein]; Nifedipine results in increased expression of and affects the localization of BCL2 protein Nifedipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]; Nifedipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein] |
CTD |
PMID:10075388 PMID:10695937 PMID:19698708 PMID:36207783 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BDNF |
brain derived neurotrophic factor |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein] |
CTD |
PMID:11279263 |
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NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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G |
CACNA1C |
calcium voltage-gated channel subunit alpha1 C |
affects response to substance multiple interactions |
ISO EXP |
CACNA1C protein affects the susceptibility to Nifedipine Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:18441296 PMID:20128810 |
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NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950
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G |
CAMK2A |
calcium/calmodulin dependent protein kinase II alpha |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]] Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein] |
CTD |
PMID:19217379 PMID:28194001 |
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NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
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G |
CASP3 |
caspase 3 |
multiple interactions |
ISO EXP |
Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; Nifedipine inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] |
CTD |
PMID:24995437 PMID:26923100 PMID:36207783 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CLU |
clusterin |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein] |
CTD |
PMID:14656996 |
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NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO EXP |
Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] Nifedipine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein] Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:20128810 PMID:21113126 |
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NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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G |
CSN2 |
casein beta |
decreases expression multiple interactions |
ISO |
Nifedipine results in decreased expression of CSN2 mRNA Nifedipine promotes the reaction [Cadmium results in decreased expression of CSN2 mRNA] |
CTD |
PMID:21167921 |
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NCBI chr 4:69,955,256...69,965,728
Ensembl chr 4:69,955,256...69,965,728
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA]; Nifedipine inhibits the reaction [nickel chloride results in increased expression of CXCL8 mRNA] |
CTD |
PMID:18938131 PMID:25045119 |
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NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
decreases activity |
ISO EXP |
Nifedipine results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 PMID:33814510 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
decreases activity multiple interactions |
EXP ISO |
Nifedipine results in decreased activity of CYP1A2 protein Nifedipine inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin] |
CTD |
PMID:10805063 PMID:18420780 PMID:19858067 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP1B1 |
cytochrome P450 family 1 subfamily B member 1 |
decreases activity |
ISO EXP |
Nifedipine results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 PMID:33814510 |
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NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
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G |
CYP2A7 |
cytochrome P450 family 2 subfamily A member 7 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2A4 protein |
CTD |
PMID:18420780 |
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NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2B10 protein |
CTD |
PMID:18420780 |
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NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP2C18 |
cytochrome P450 family 2 subfamily C member 18 |
multiple interactions |
ISO |
Nifedipine promotes the reaction [Cyclosporine results in increased expression of CYP2C11 protein] |
CTD |
PMID:28899749 |
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NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
decreases activity |
EXP ISO |
Nifedipine results in decreased activity of CYP2C8 protein Nifedipine results in decreased activity of CYP2C29 protein |
CTD |
PMID:15601807 PMID:18420780 |
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NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2C9 protein |
CTD |
PMID:18420780 |
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NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2D6 protein |
CTD |
PMID:18420780 |
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NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2E1 protein |
CTD |
PMID:18420780 |
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NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP2J2 |
cytochrome P450 family 2 subfamily J member 2 |
decreases activity |
EXP |
Nifedipine results in decreased activity of CYP2J2 protein |
CTD |
PMID:30965050 |
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NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
affects oxidation multiple interactions increases hydroxylation increases oxidation increases expression affects metabolic processing increases metabolic processing |
EXP ISO |
CYP3A4 protein affects the oxidation of Nifedipine [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine; Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] 6',7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; [Nifedipine binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Nifedipine] Nifedipine results in increased expression of CYP3A4 mRNA; Nifedipine results in increased expression of CYP3A4 protein CYP3A4 protein affects the metabolism of Nifedipine |
CTD |
PMID:2271712 PMID:12851153 PMID:15286053 PMID:15618748 PMID:15634941 PMID:15784650 PMID:15937564 PMID:16712844 PMID:16837568 PMID:17041008 PMID:17954527 PMID:18846481 PMID:19230594 PMID:19299527 PMID:19501153 PMID:19858067 PMID:20863320 PMID:22524704 PMID:23146034 PMID:25069801 More...
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
DDIT3 |
DNA damage inducible transcript 3 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein] |
CTD |
PMID:22226148 |
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NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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G |
DMD |
dystrophin |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [DMD gene mutant form results in increased abundance of Calcium]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate] |
CTD |
PMID:24349043 |
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NCBI chr X:31,119,222...33,339,388
Ensembl chr X:31,097,677...33,339,609
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G |
DRD2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]] |
CTD |
PMID:11124974 |
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NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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G |
DRD3 |
dopamine receptor D3 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]] |
CTD |
PMID:19217379 |
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NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
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G |
EDN1 |
endothelin 1 |
decreases activity increases activity multiple interactions |
ISO |
Nifedipine results in decreased activity of EDN1 protein Nifedipine results in increased activity of EDN1 protein Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter] |
CTD |
PMID:7528292 PMID:11435416 PMID:12628492 |
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NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
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G |
EIF2AK3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] |
CTD |
PMID:22226148 |
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NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
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G |
ELK1 |
ETS transcription factor ELK1 |
multiple interactions |
ISO |
Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:17913375 |
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NCBI chr X:47,635,520...47,650,604
Ensembl chr X:47,635,521...47,650,604
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G |
ESR1 |
estrogen receptor 1 |
increases activity |
EXP |
Nifedipine results in increased activity of ESR1 protein |
CTD |
PMID:25257666 |
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NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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G |
FGF2 |
fibroblast growth factor 2 |
affects response to substance multiple interactions |
EXP |
Nifedipine affects the susceptibility to FGF2 protein Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA] |
CTD |
PMID:15141722 PMID:16188231 |
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NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236
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G |
FGF7 |
fibroblast growth factor 7 |
increases secretion increases expression |
EXP |
Nifedipine results in increased secretion of FGF7 protein Nifedipine results in increased expression of FGF7 mRNA |
CTD |
PMID:11023675 |
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NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression |
EXP ISO |
Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA] Nifedipine results in decreased expression of FOS protein [Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride affects the expression of FOS mRNA]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein] |
CTD |
PMID:7534335 PMID:16188231 PMID:17913375 PMID:20211981 |
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
GFAP |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] |
CTD |
PMID:21863293 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GRIA1 |
glutamate ionotropic receptor AMPA type subunit 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein] |
CTD |
PMID:28194001 |
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NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869
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G |
GSTP1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
HAVCR1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein] |
CTD |
PMID:36207783 |
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NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
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G |
HDAC4 |
histone deacetylase 4 |
affects localization |
ISO |
Nifedipine affects the localization of HDAC4 protein |
CTD |
PMID:20559781 |
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NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654
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G |
HGF |
hepatocyte growth factor |
increases expression |
EXP |
Nifedipine results in increased expression of HGF protein |
CTD |
PMID:15071489 |
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NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438
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G |
HLA-DQB1 |
major histocompatibility complex, class II, DQ beta 1 |
affects expression |
EXP |
Nifedipine affects the expression of HLA-DQB1 mRNA |
CTD |
PMID:25811541 |
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NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
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G |
HMOX1 |
heme oxygenase 1 |
increases expression |
EXP |
Nifedipine results in increased expression of HMOX1 protein |
CTD |
PMID:21525764 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HNMT |
histamine N-methyltransferase |
decreases activity |
ISO |
Nifedipine results in decreased activity of HNMT protein |
CTD |
PMID:2408645 |
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NCBI chr 2:137,964,473...138,016,364
Ensembl chr 2:137,964,020...138,016,364
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G |
HSF1 |
heat shock transcription factor 1 |
increases activity |
EXP |
Nifedipine results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein] |
CTD |
PMID:22226148 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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G |
IGF1 |
insulin like growth factor 1 |
decreases response to substance |
EXP |
Nifedipine results in decreased susceptibility to IGF1 protein |
CTD |
PMID:16485066 |
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NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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G |
IGF2 |
insulin like growth factor 2 |
decreases response to substance |
EXP |
Nifedipine results in decreased susceptibility to IGF2 protein |
CTD |
PMID:16485066 |
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NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391
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G |
IL1B |
interleukin 1 beta |
increases expression |
EXP |
Nifedipine results in increased expression of IL1B mRNA |
CTD |
PMID:28138970 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
INS-IGF2 |
INS-IGF2 readthrough |
multiple interactions decreases expression |
ISO |
Nifedipine inhibits the reaction [Quercetin results in increased secretion of INS1 protein] Nifedipine results in decreased expression of INS1 protein |
CTD |
PMID:7564366 PMID:23530660 |
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NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
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G |
KCNA1 |
potassium voltage-gated channel subfamily A member 1 |
multiple interactions |
ISO |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] promotes the reaction [Potassium Chloride results in increased expression of KCNA1 mRNA] |
CTD |
PMID:20211981 |
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NCBI chr12:4,909,905...4,918,256
Ensembl chr12:4,909,905...4,918,256
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G |
KCNA3 |
potassium voltage-gated channel subfamily A member 3 |
decreases activity |
EXP |
Nifedipine results in decreased activity of KCNA3 protein |
CTD |
PMID:17638537 |
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NCBI chr 1:110,653,560...110,674,940
Ensembl chr 1:110,653,560...110,674,940
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G |
KCNC3 |
potassium voltage-gated channel subfamily C member 3 |
multiple interactions |
ISO |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride results in increased expression of KCNC3 mRNA] |
CTD |
PMID:20211981 |
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NCBI chr19:50,311,937...50,333,536
Ensembl chr19:50,311,937...50,333,515
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G |
LCN2 |
lipocalin 2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein] |
CTD |
PMID:36207783 |
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NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein] Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein] |
CTD |
PMID:15086530 PMID:25045119 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein] Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein] |
CTD |
PMID:15086530 PMID:25045119 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MMP9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
Nifedipine results in decreased expression of and results in decreased activity of MMP9 protein |
CTD |
PMID:18204791 |
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NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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G |
MYC |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
EXP |
Nifedipine results in increased expression of MYC protein |
CTD |
PMID:10695937 |
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NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
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G |
MYH10 |
myosin heavy chain 10 |
decreases expression |
EXP ISO |
Nifedipine results in decreased expression of MYH10 protein |
CTD |
PMID:20530298 |
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NCBI chr17:8,474,212...8,630,725
Ensembl chr17:8,474,207...8,631,376
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G |
MYH11 |
myosin heavy chain 11 |
increases expression |
EXP ISO |
Nifedipine results in increased expression of MYH11 protein |
CTD |
PMID:20530298 |
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NCBI chr16:15,703,135...15,857,028
Ensembl chr16:15,703,135...15,858,438
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G |
MYH7 |
myosin heavy chain 7 |
decreases response to substance |
EXP |
MYH7 gene mutant form results in decreased susceptibility to Nifedipine |
CTD |
PMID:29741611 |
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NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660
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G |
MYL9 |
myosin light chain 9 |
decreases phosphorylation |
ISO |
Nifedipine results in decreased phosphorylation of MYL9 protein |
CTD |
PMID:17272349 |
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NCBI chr20:36,541,519...36,551,447
Ensembl chr20:36,541,497...36,551,447
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G |
NAMPT |
nicotinamide phosphoribosyltransferase |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Glucose results in increased secretion of NAMPT protein] |
CTD |
PMID:23536823 |
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NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966
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G |
NEFL |
neurofilament light chain |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein] |
CTD |
PMID:21863293 |
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NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721
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G |
NEFM |
neurofilament medium chain |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] |
CTD |
PMID:21863293 |
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NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
EXP |
Nifedipine affects the localization of NFE2L2 protein |
CTD |
PMID:21525764 |
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
NFKBIA |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:23583884 |
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NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NGF |
nerve growth factor |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [NGF protein results in increased uptake of Calcium] |
CTD |
PMID:1374475 |
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NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA] |
CTD |
PMID:11245857 PMID:24349043 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOS3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] |
CTD |
PMID:20562903 |
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NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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G |
NPPA |
natriuretic peptide A |
decreases expression |
ISO |
Nifedipine results in decreased expression of NPPA mRNA |
CTD |
PMID:20559781 |
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NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
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G |
NPPB |
natriuretic peptide B |
multiple interactions |
ISO |
[Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA |
CTD |
PMID:17666919 |
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NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
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G |
NR1H4 |
nuclear receptor subfamily 1 group H member 4 |
multiple interactions decreases activity |
EXP |
Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] Nifedipine results in decreased activity of NR1H4 protein |
CTD |
PMID:25257666 |
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NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
multiple interactions |
EXP |
[Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Nifedipine binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:14570758 PMID:17041008 PMID:21291553 PMID:25069801 |
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NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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G |
OLR1 |
oxidized low density lipoprotein receptor 1 |
decreases expression |
EXP |
Nifedipine results in decreased expression of OLR1 mRNA |
CTD |
PMID:12072588 |
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NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138
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G |
PDCD4 |
programmed cell death 4 |
decreases expression |
EXP |
Nifedipine results in decreased expression of PDCD4 mRNA |
CTD |
PMID:21873647 |
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NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
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G |
PLA2G4A |
phospholipase A2 group IVA |
multiple interactions |
EXP ISO |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] |
CTD |
PMID:18938131 PMID:19162293 PMID:23583884 |
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NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
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G |
PPIF |
peptidylprolyl isomerase F |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [Iohexol results in increased expression of PPIF protein] |
CTD |
PMID:36207783 |
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NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334
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G |
PRL |
prolactin |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [bisphenol A results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Coumestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Dieldrin results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Endosulfan results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Estradiol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein] |
CTD |
PMID:15811834 PMID:17174995 |
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NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP ISO |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18388244 PMID:18938131 PMID:19063610 PMID:23583884 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA protein] |
CTD |
PMID:23583884 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
REN |
renin |
multiple interactions increases activity increases expression |
EXP |
[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein; Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein] Nifedipine results in increased expression of REN protein |
CTD |
PMID:3142437 PMID:3313686 PMID:3326920 PMID:6184561 PMID:6354932 |
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NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
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G |
SCN5A |
sodium voltage-gated channel alpha subunit 5 |
decreases activity |
ISO |
Nifedipine results in decreased activity of SCN5A protein |
CTD |
PMID:16331678 PMID:17978865 |
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NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743
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G |
SERPINB2 |
serpin family B member 2 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA] |
CTD |
PMID:18388244 |
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NCBI chr18:63,887,705...63,903,888
Ensembl chr18:63,871,692...63,903,888
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G |
SLC10A1 |
solute carrier family 10 member 1 |
multiple interactions |
EXP |
Nifedipine promotes the reaction [SLC10A1 protein results in increased uptake of Indocyanine Green] |
CTD |
PMID:32209977 |
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NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
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G |
SLC1A2 |
solute carrier family 1 member 2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] |
CTD |
PMID:26988466 |
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NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063
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G |
SLC22A1 |
solute carrier family 22 member 1 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718
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G |
SLC22A3 |
solute carrier family 22 member 3 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577
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G |
SLC22A4 |
solute carrier family 22 member 4 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190
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G |
SLC22A5 |
solute carrier family 22 member 5 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:21641380 |
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NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613
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G |
SLC23A2 |
solute carrier family 23 member 2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA] |
CTD |
PMID:12788230 |
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NCBI chr20:4,852,358...5,010,313
Ensembl chr20:4,852,356...5,010,293
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G |
SOD2 |
superoxide dismutase 2 |
multiple interactions affects response to substance increases expression |
ISO EXP |
[SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine SOD2 protein affects the susceptibility to Nifedipine Nifedipine results in increased expression of SOD2 mRNA; Nifedipine results in increased expression of SOD2 protein |
CTD |
PMID:18327084 PMID:19501153 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SPP1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA] |
CTD |
PMID:12788230 |
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NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
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G |
STAR |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein] Nifedipine promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA] |
CTD |
PMID:19822634 PMID:22226148 |
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NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
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G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions |
ISO |
[Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA |
CTD |
PMID:17666919 |
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NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TNF |
tumor necrosis factor |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein] |
CTD |
PMID:23583884 |
|
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TNFAIP3 |
TNF alpha induced protein 3 |
decreases expression |
EXP |
Nifedipine results in decreased expression of TNFAIP3 mRNA |
CTD |
PMID:21873647 |
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NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314
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G |
TP53 |
tumor protein p53 |
increases activity |
EXP |
Nifedipine results in increased activity of TP53 protein |
CTD |
PMID:12082016 |
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NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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G |
TPD52 |
tumor protein D52 |
increases expression |
EXP |
Nifedipine results in increased expression of TPD52 mRNA |
CTD |
PMID:21873647 |
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NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232
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G |
VEGFA |
vascular endothelial growth factor A |
multiple interactions |
EXP ISO |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]] |
CTD |
PMID:18388244 PMID:18938131 PMID:19063610 PMID:19162293 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
VIM |
vimentin |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] |
CTD |
PMID:21863293 |
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NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
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