PLA2G4A (phospholipase A2 group IVA) - Rat Genome Database

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Gene: PLA2G4A (phospholipase A2 group IVA) Homo sapiens
Analyze
Symbol: PLA2G4A
Name: phospholipase A2 group IVA
RGD ID: 735872
HGNC Page HGNC:9035
Description: Enables several functions, including calcium ion binding activity; phospholipase activity; and phospholipid binding activity. Involved in glycerolipid metabolic process; icosanoid metabolic process; and positive regulation of platelet activation. Located in Golgi membrane; cytosol; and nuclear envelope.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: calcium-dependent phospholipid-binding protein; cPLA2; cPLA2-alpha; cytosolic phospholipase A2; GURDP; lysophospholipase; MGC126350; phosphatidylcholine 2-acylhydrolase; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: GLUCO223_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,828,949 - 186,988,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,828,949 - 186,988,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371186,798,081 - 186,958,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,064,655 - 185,224,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 341183,529,761 - 183,689,770NCBI
Celera1159,908,366 - 160,068,522 (+)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1158,032,476 - 158,192,352 (+)NCBIHuRef
CHM1_11188,219,298 - 188,379,410 (+)NCBICHM1_1
T2T-CHM13v2.01186,183,301 - 186,343,553 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2,3,4-tetrahydroisoquinoline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4',6-tetrachlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
AACOCF3  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium sulfate (anhydrous)  (EXP)
amiodarone  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
arachidonic acid  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
ATP  (ISO)
beclomethasone  (EXP)
belinostat  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (EXP)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
budesonide  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP,ISO)
capsaicin  (EXP)
carbamazepine  (EXP,ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
dioxygen  (EXP)
diphenhydramine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
entinostat  (EXP)
ethanol  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP)
fluticasone  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (EXP)
genistein  (EXP)
gentamycin  (ISO)
histamine  (EXP)
hydrogen peroxide  (ISO)
icosanoid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead nitrate  (EXP)
lead(II) chloride  (EXP)
leukotriene B4  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
melittin  (EXP)
mercury dibromide  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (EXP)
methylseleninic acid  (EXP)
N'-Nitrosonornicotine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nicotine  (ISO)
nifedipine  (EXP,ISO)
nitric oxide  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
omeprazole  (EXP)
orientin  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
prednisolone  (EXP)
procymidone  (ISO)
progesterone  (EXP)
prostaglandin E2  (EXP,ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sulfadimethoxine  (ISO)
sulindac  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP)
terephthalic acid  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
triamcinolone acetonide  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vorinostat  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid metabolic process  (IDA,IEA,ISO)
arachidonic acid secretion  (IEA,ISO)
cellular response to antibiotic  (IEA,ISO)
cellular response to homocysteine  (ISO)
decidualization  (ISO)
establishment of localization in cell  (IEA,ISO)
fatty acid biosynthetic process  (IEA)
fatty acid metabolic process  (IEA)
glycerol metabolic process  (IEA)
glycerophospholipid catabolic process  (IBA,IEA)
glycerophospholipid metabolic process  (IEA)
icosanoid biosynthetic process  (IEA,ISO)
icosanoid metabolic process  (NAS)
leukotriene biosynthetic process  (IEA,IMP)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
luteolysis  (ISO)
monoacylglycerol biosynthetic process  (IDA)
ovulation from ovarian follicle  (ISO)
phosphatidylcholine acyl-chain remodeling  (IDA)
phosphatidylcholine catabolic process  (IDA,IEA)
phosphatidylglycerol catabolic process  (IDA)
phospholipid catabolic process  (IEA)
platelet activating factor biosynthetic process  (IEA,NAS)
positive regulation of apoptotic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of platelet activation  (IMP)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of vesicle fusion  (ISO)
prostaglandin biosynthetic process  (IDA,IEA,IMP)
prostaglandin metabolic process  (IEA)
regulation of cell population proliferation  (IEA,ISO)
response to calcium ion  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (ISO)
response to methylmercury  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to vitamin D  (ISO)
surfactant homeostasis  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease. Aukema HM, etal., FASEB J. 2003 Feb;17(2):298-300. Epub 2002 Dec 17.
2. Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during Wallerian degeneration. De S, etal., Mol Cell Neurosci. 2003 Nov;24(3):753-65.
3. The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. Fevre C, etal., Biochim Biophys Acta. 2011 Jun;1811(6):409-17. Epub 2010 Dec 21.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. Gracia-Sancho J, etal., J Hepatol. 2007 Aug;47(2):220-7. Epub 2007 Apr 5.
6. Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. Lee KL, etal., J Med Chem. 2007 Mar 22;50(6):1380-400. Epub 2007 Feb 17.
7. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Lopez-Vales R, etal., Brain. 2008 Oct;131(Pt 10):2620-31. Epub 2008 Aug 21.
8. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
9. Molecules in focus: cytosolic phospholipase A2-alpha. Niknami M, etal., Int J Biochem Cell Biol. 2009 May;41(5):994-7. doi: 10.1016/j.biocel.2008.07.017. Epub 2008 Aug 8.
10. Negative feedback between secretory and cytosolic phospholipase A2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats. Offer S, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L523-9. Epub 2004 Nov 19.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
18. Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. Shi Y, etal., Prostaglandins Leukot Essent Fatty Acids. 2006 May;74(5):309-15. Epub 2006 Apr 18.
19. Cellular and molecular bases of the initiation of fever. Steiner AA, etal., PLoS Biol. 2006 Sep;4(9):e284.
20. GTP-binding protein mediated phospholipase A2 activation in rat liver during the progression of sepsis. Tong LJ, etal., Mol Cell Biochem. 1998 Dec;189(1-2):55-61.
21. Human cardiac muscle magnesium and potassium concentrations: can skeletal muscle, mononuclear blood cells, erythrocyte and plasma concentrations provide a surrogate measure? Tovey JA, etal., Ann Clin Biochem. 1992 Jul;29 ( Pt 4):461-2.
22. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. Xia P, etal., J Clin Invest. 1995 Aug;96(2):733-40.
23. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. Yaksh TL, etal., J Pharmacol Exp Ther. 2006 Jan;316(1):466-75. Epub 2005 Oct 3.
24. Overexpression of genes in the CA1 hippocampus region of adult rat following episodes of global ischemia. Yakubov E, etal., Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):10-26.
25. Involvement of p38 MAP kinase in burn-induced degradation of membrane phospholipids and upregulation of cPLA2 in cardiac myocytes. Zhang JP, etal., Shock. 2007 Jul;28(1):86-93.
Additional References at PubMed
PMID:1869522   PMID:1904318   PMID:7782073   PMID:7794891   PMID:7800505   PMID:7862535   PMID:7999086   PMID:8083230   PMID:8175726   PMID:8381049   PMID:8612580   PMID:8636128  
PMID:8702602   PMID:8910365   PMID:9239738   PMID:9377118   PMID:9425121   PMID:9430701   PMID:9468497   PMID:9665851   PMID:9745929   PMID:9875225   PMID:10085124   PMID:10319815  
PMID:10625659   PMID:10978317   PMID:11375391   PMID:11416127   PMID:12048163   PMID:12050227   PMID:12124392   PMID:12163506   PMID:12414998   PMID:12477932   PMID:12672805   PMID:12765847  
PMID:12885780   PMID:14599294   PMID:14609334   PMID:14686920   PMID:14709560   PMID:14726390   PMID:14769798   PMID:14963030   PMID:15007070   PMID:15041036   PMID:15118355   PMID:15259375  
PMID:15276701   PMID:15302935   PMID:15305015   PMID:15318030   PMID:15331599   PMID:15358156   PMID:15474031   PMID:15475363   PMID:15489334   PMID:15789617   PMID:15862967   PMID:15975962  
PMID:16181776   PMID:16221889   PMID:16344560   PMID:16407173   PMID:16409471   PMID:16462602   PMID:16585943   PMID:16603549   PMID:16617059   PMID:16710414   PMID:16754327   PMID:16829784  
PMID:16844764   PMID:16963226   PMID:16964243   PMID:17081983   PMID:17178883   PMID:17344094   PMID:17417066   PMID:17460547   PMID:17472963   PMID:17629734   PMID:17672871   PMID:17685590  
PMID:17873281   PMID:17901074   PMID:17932043   PMID:17971499   PMID:17976189   PMID:18065419   PMID:18280113   PMID:18330356   PMID:18388244   PMID:18451993   PMID:18471798   PMID:18502815  
PMID:18562188   PMID:18566601   PMID:18583979   PMID:18632668   PMID:18665843   PMID:18686860   PMID:18765662   PMID:18818748   PMID:18840708   PMID:19019335   PMID:19091957   PMID:19176526  
PMID:19237603   PMID:19280714   PMID:19336370   PMID:19401382   PMID:19450127   PMID:19527514   PMID:19560328   PMID:19625654   PMID:19632995   PMID:19675210   PMID:19717620   PMID:19753100  
PMID:19778898   PMID:19795129   PMID:19913121   PMID:20034614   PMID:20056178   PMID:20066429   PMID:20069553   PMID:20112044   PMID:20140262   PMID:20203101   PMID:20211985   PMID:20227521  
PMID:20351714   PMID:20379614   PMID:20392485   PMID:20435073   PMID:20464283   PMID:20478385   PMID:20628086   PMID:20635443   PMID:20643646   PMID:20705608   PMID:20802406   PMID:20808133  
PMID:21097525   PMID:21127289   PMID:21148506   PMID:21185392   PMID:21198294   PMID:21247147   PMID:21268080   PMID:21315000   PMID:21478406   PMID:21536681   PMID:21771656   PMID:21825068  
PMID:21862584   PMID:21873635   PMID:21896865   PMID:22003202   PMID:22138395   PMID:22274867   PMID:22378731   PMID:22398721   PMID:22456504   PMID:22648535   PMID:22658674   PMID:22728329  
PMID:22863883   PMID:22895089   PMID:22911431   PMID:22939629   PMID:22949513   PMID:23043861   PMID:23219238   PMID:23268370   PMID:23307260   PMID:23549331   PMID:23801329   PMID:23948114  
PMID:24349530   PMID:24366870   PMID:24667918   PMID:24721622   PMID:25102418   PMID:25102815   PMID:25365190   PMID:25609649   PMID:25617738   PMID:25761116   PMID:25904158   PMID:25969996  
PMID:26162318   PMID:26183771   PMID:26303530   PMID:26416244   PMID:26496610   PMID:26525102   PMID:27133131   PMID:27528014   PMID:27554058   PMID:27642067   PMID:28108057   PMID:28383549  
PMID:28649002   PMID:28724385   PMID:28887431   PMID:29117863   PMID:29167338   PMID:29307829   PMID:29342349   PMID:29551681   PMID:29893858   PMID:30021884   PMID:30071514   PMID:30103930  
PMID:30360807   PMID:31003849   PMID:31050338   PMID:31177093   PMID:31474631   PMID:31519766   PMID:32077754   PMID:32807901   PMID:33023184   PMID:33086624   PMID:33397691   PMID:33550612  
PMID:33853093   PMID:34131250   PMID:34255137   PMID:34283812   PMID:34474084   PMID:34502319   PMID:34889025   PMID:34946532   PMID:34969839   PMID:35256949   PMID:35271311   PMID:35705959  
PMID:35831314   PMID:36168628   PMID:36623677   PMID:37774976   PMID:38367927   PMID:38454407  


Genomics

Comparative Map Data
PLA2G4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,828,949 - 186,988,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,828,949 - 186,988,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371186,798,081 - 186,958,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,064,655 - 185,224,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 341183,529,761 - 183,689,770NCBI
Celera1159,908,366 - 160,068,522 (+)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1158,032,476 - 158,192,352 (+)NCBIHuRef
CHM1_11188,219,298 - 188,379,410 (+)NCBICHM1_1
T2T-CHM13v2.01186,183,301 - 186,343,553 (+)NCBIT2T-CHM13v2.0
Pla2g4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,705,369 - 149,837,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,705,369 - 149,837,041 (-)EnsemblGRCm39 Ensembl
GRCm381149,829,618 - 149,961,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,829,618 - 149,961,290 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,676,752 - 151,808,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,591,840 - 151,723,502 (-)NCBIMGSCv36mm8
Celera1152,270,492 - 152,407,425 (-)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.51NCBI
Pla2g4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,427,921 - 64,572,352 (-)NCBIGRCr8
mRatBN7.21361,877,818 - 62,022,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1361,877,813 - 62,022,266 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,503,114 - 64,647,490 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01365,794,043 - 65,938,034 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,055,598 - 63,199,601 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,062,252 - 67,206,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1366,988,937 - 67,206,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,027,801 - 72,172,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,135,729 - 64,280,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,149,803 - 64,294,883 (-)NCBI
Celera1361,840,531 - 61,984,375 (-)NCBICelera
Cytogenetic Map13q21NCBI
Pla2g4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,257,355 - 25,394,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,257,361 - 25,392,079 (+)NCBIChiLan1.0ChiLan1.0
PLA2G4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2162,725,111 - 62,884,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,405,808 - 62,566,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,362,600 - 162,521,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,512,870 - 166,672,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,512,870 - 166,672,101 (+)Ensemblpanpan1.1panPan2
PLA2G4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,804,412 - 19,955,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,832,664 - 19,966,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,327,033 - 19,477,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,541,768 - 19,692,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,570,229 - 19,692,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,447,440 - 19,598,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,556,751 - 19,707,439 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,688,892 - 19,840,168 (+)NCBIUU_Cfam_GSD_1.0
Pla2g4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,712,619 - 85,843,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364813,559,358 - 3,689,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364813,559,377 - 3,689,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,859,051 - 128,162,638 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,853,581 - 128,164,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,386,385 - 140,623,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,443,480 - 42,590,895 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,443,385 - 42,590,431 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605543,569,644 - 43,761,073 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,597,005 - 6,744,286 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248146,597,248 - 6,744,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G4A
126 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_024420.3(PLA2G4A):c.331T>C (p.Ser111Pro) single nucleotide variant Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder [RCV000009647] Chr1:186894164 [GRCh38]
Chr1:186863296 [GRCh37]
Chr1:1q31.1		 pathogenic
NM_024420.3(PLA2G4A):c.1454G>A (p.Arg485His) single nucleotide variant Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder [RCV000009648] Chr1:186956219 [GRCh38]
Chr1:186925351 [GRCh37]
Chr1:1q31.1		 pathogenic|likely pathogenic
NM_024420.2(PLA2G4A):c.-70+11000G>T single nucleotide variant Lung cancer [RCV000090118] Chr1:186840035 [GRCh38]
Chr1:186809167 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.2(PLA2G4A):c.1764+385A>C single nucleotide variant Lung cancer [RCV000090119] Chr1:186965978 [GRCh38]
Chr1:186935110 [GRCh37]
Chr1:1q31.1		 uncertain significance
GRCh38/hg38 1q25.3-31.1(chr1:182137726-186931125)x1 copy number loss See cases [RCV000053949] Chr1:182137726..186931125 [GRCh38]
Chr1:182106861..186900257 [GRCh37]
Chr1:180373484..185166880 [NCBI36]
Chr1:1q25.3-31.1		 pathogenic
GRCh38/hg38 1q25.2-32.1(chr1:179032905-199724897)x1 copy number loss See cases [RCV000053948] Chr1:179032905..199724897 [GRCh38]
Chr1:179002040..199694025 [GRCh37]
Chr1:177268663..197960648 [NCBI36]
Chr1:1q25.2-32.1		 pathogenic
NM_024420.2(PLA2G4A):c.1461G>A (p.Gly487=) single nucleotide variant Malignant melanoma [RCV000064391] Chr1:186956226 [GRCh38]
Chr1:186925358 [GRCh37]
Chr1:185191981 [NCBI36]
Chr1:1q31.1		 not provided
GRCh38/hg38 1q25.2-31.3(chr1:176595962-196301688)x1 copy number loss See cases [RCV000134144] Chr1:176595962..196301688 [GRCh38]
Chr1:176565098..196270818 [GRCh37]
Chr1:174831721..194537441 [NCBI36]
Chr1:1q25.2-31.3		 pathogenic
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1		 pathogenic
GRCh38/hg38 1q31.1(chr1:186792934-187904115)x3 copy number gain See cases [RCV000135527] Chr1:186792934..187904115 [GRCh38]
Chr1:186762066..187873246 [GRCh37]
Chr1:185028689..186139869 [NCBI36]
Chr1:1q31.1		 uncertain significance
GRCh38/hg38 1q31.1(chr1:185959703-187743891)x3 copy number gain See cases [RCV000138114] Chr1:185959703..187743891 [GRCh38]
Chr1:185928835..187713022 [GRCh37]
Chr1:184195458..185979645 [NCBI36]
Chr1:1q31.1		 uncertain significance
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2		 pathogenic
GRCh38/hg38 1q31.1(chr1:185977899-187712734)x3 copy number gain See cases [RCV000142712] Chr1:185977899..187712734 [GRCh38]
Chr1:185947031..187681865 [GRCh37]
Chr1:184213654..185948488 [NCBI36]
Chr1:1q31.1		 uncertain significance
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1		 pathogenic
GRCh37/hg19 1q25.3-31.2(chr1:181572003-191524283)x1 copy number loss See cases [RCV000240242] Chr1:181572003..191524283 [GRCh37]
Chr1:1q25.3-31.2		 pathogenic
NM_024420.3(PLA2G4A):c.1598G>A (p.Arg533Gln) single nucleotide variant not specified [RCV003321071] Chr1:186965427 [GRCh38]
Chr1:186934559 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1723G>C (p.Asp575His) single nucleotide variant Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder [RCV000766189] Chr1:186965552 [GRCh38]
Chr1:186934684 [GRCh37]
Chr1:1q31.1		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265)x1 copy number loss See cases [RCV000448809] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758)x1 copy number loss See cases [RCV000448686] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179011314-199022759)x1 copy number loss See cases [RCV000512128] Chr1:179011314..199022759 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q25.1-31.1(chr1:173131908-187406532)x1 copy number loss not provided [RCV000736735] Chr1:173131908..187406532 [GRCh37]
Chr1:1q25.1-31.1		 pathogenic
GRCh37/hg19 1q31.1(chr1:186307064-186835137)x3 copy number gain not provided [RCV000736772] Chr1:186307064..186835137 [GRCh37]
Chr1:1q31.1		 benign
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
NM_024420.3(PLA2G4A):c.670G>A (p.Val224Ile) single nucleotide variant not provided [RCV000914072] Chr1:186932874 [GRCh38]
Chr1:186902006 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1758G>A (p.Pro586=) single nucleotide variant PLA2G4A-related condition [RCV003968178]|not provided [RCV000895136] Chr1:186965587 [GRCh38]
Chr1:186934719 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.246T>C (p.Asn82=) single nucleotide variant not provided [RCV000917611] Chr1:186893141 [GRCh38]
Chr1:186862273 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.2247A>G (p.Ala749=) single nucleotide variant not provided [RCV000965578] Chr1:186988505 [GRCh38]
Chr1:186957637 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1995C>T (p.Ile665=) single nucleotide variant not provided [RCV000899153] Chr1:186979349 [GRCh38]
Chr1:186948481 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1519T>C (p.Leu507=) single nucleotide variant not provided [RCV000983665] Chr1:186956284 [GRCh38]
Chr1:186925416 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1962T>G (p.Gly654=) single nucleotide variant Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder [RCV002502888]|not provided [RCV000943517] Chr1:186979316 [GRCh38]
Chr1:186948448 [GRCh37]
Chr1:1q31.1		 benign|likely benign
NM_024420.3(PLA2G4A):c.1765-3T>C single nucleotide variant PLA2G4A-related condition [RCV003928580]|not provided [RCV000974168] Chr1:186977590 [GRCh38]
Chr1:186946722 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1380T>C (p.Asn460=) single nucleotide variant not provided [RCV000946541] Chr1:186956145 [GRCh38]
Chr1:186925277 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1909A>G (p.Ile637Val) single nucleotide variant not provided [RCV000949472] Chr1:186977737 [GRCh38]
Chr1:186946869 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.2118+4_2118+7del deletion Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder [RCV000766190] Chr1:186979473..186979476 [GRCh38]
Chr1:186948605..186948608 [GRCh37]
Chr1:1q31.1		 pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
NM_024420.3(PLA2G4A):c.1011C>T (p.Asp337=) single nucleotide variant not provided [RCV000919423] Chr1:186940072 [GRCh38]
Chr1:186909204 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.494dup (p.Arg166fs) duplication Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder [RCV000995604] Chr1:186911324..186911325 [GRCh38]
Chr1:186880456..186880457 [GRCh37]
Chr1:1q31.1		 pathogenic
NM_024420.3(PLA2G4A):c.703T>A (p.Ser235Thr) single nucleotide variant Inborn genetic diseases [RCV003272765] Chr1:186939015 [GRCh38]
Chr1:186908147 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.355G>A (p.Glu119Lys) single nucleotide variant not provided [RCV000909703] Chr1:186894188 [GRCh38]
Chr1:186863320 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1952= (p.Arg651=) variation not provided [RCV000955154] Chr1:186977780 [GRCh38]
Chr1:186946912 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1537C>A (p.Gln513Lys) single nucleotide variant not provided [RCV000944031] Chr1:186956302 [GRCh38]
Chr1:186925434 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.115+10C>G single nucleotide variant not provided [RCV000940542] Chr1:186870526 [GRCh38]
Chr1:186839658 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1579+7G>T single nucleotide variant not provided [RCV000935065] Chr1:186956351 [GRCh38]
Chr1:186925483 [GRCh37]
Chr1:1q31.1		 likely benign
GRCh37/hg19 1q31.1(chr1:186137950-187028283)x3 copy number gain not provided [RCV002473872] Chr1:186137950..187028283 [GRCh37]
Chr1:1q31.1		 uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:177551193-199599056)x1 copy number loss not provided [RCV001005157] Chr1:177551193..199599056 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q31.1(chr1:186912015-187132574)x3 copy number gain not provided [RCV001258490] Chr1:186912015..187132574 [GRCh37]
Chr1:1q31.1		 likely pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265) copy number loss not specified [RCV002053769] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q25.2-31.1(chr1:178522021-190322133)x1 copy number loss not provided [RCV001836604] Chr1:178522021..190322133 [GRCh37]
Chr1:1q25.2-31.1		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737) copy number loss not specified [RCV002053780] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758) copy number loss not specified [RCV002053736] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3		 pathogenic
NC_000001.10:g.(?_185703912)_(186957640_?)dup duplication not provided [RCV003122652] Chr1:185703912..186957640 [GRCh37]
Chr1:1q25.3-31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1582C>T (p.Pro528Ser) single nucleotide variant Inborn genetic diseases [RCV003263214] Chr1:186965411 [GRCh38]
Chr1:186934543 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1090G>A (p.Ala364Thr) single nucleotide variant Inborn genetic diseases [RCV003284567] Chr1:186946693 [GRCh38]
Chr1:186915825 [GRCh37]
Chr1:1q31.1		 uncertain significance
GRCh37/hg19 1q25.2-31.2(chr1:179727182-192260142)x1 copy number loss not provided [RCV002473949] Chr1:179727182..192260142 [GRCh37]
Chr1:1q25.2-31.2		 pathogenic
NM_024420.3(PLA2G4A):c.637T>C (p.Tyr213His) single nucleotide variant Inborn genetic diseases [RCV002967843]|not provided [RCV002967844] Chr1:186932841 [GRCh38]
Chr1:186901973 [GRCh37]
Chr1:1q31.1		 likely benign|uncertain significance
NM_024420.3(PLA2G4A):c.1091C>T (p.Ala364Val) single nucleotide variant Inborn genetic diseases [RCV002688886] Chr1:186946694 [GRCh38]
Chr1:186915826 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1131C>T (p.Val377=) single nucleotide variant not provided [RCV002756095] Chr1:186946734 [GRCh38]
Chr1:186915866 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.322A>T (p.Thr108Ser) single nucleotide variant not provided [RCV002947252] Chr1:186894155 [GRCh38]
Chr1:186863287 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1960+4A>C single nucleotide variant PLA2G4A-related condition [RCV003916637]|not provided [RCV002947385] Chr1:186977792 [GRCh38]
Chr1:186946924 [GRCh37]
Chr1:1q31.1		 benign
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_024420.3(PLA2G4A):c.2174G>T (p.Arg725Leu) single nucleotide variant Inborn genetic diseases [RCV002902092] Chr1:186988432 [GRCh38]
Chr1:186957564 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.966A>T (p.Ala322=) single nucleotide variant not provided [RCV002842497] Chr1:186940027 [GRCh38]
Chr1:186909159 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.450G>A (p.Leu150=) single nucleotide variant not provided [RCV002996221] Chr1:186911281 [GRCh38]
Chr1:186880413 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.569T>C (p.Val190Ala) single nucleotide variant not provided [RCV003012098] Chr1:186932773 [GRCh38]
Chr1:186901905 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.2118+11C>T single nucleotide variant not provided [RCV002775838] Chr1:186979483 [GRCh38]
Chr1:186948615 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.918+19T>G single nucleotide variant not provided [RCV002662837] Chr1:186939249 [GRCh38]
Chr1:186908381 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1683A>G (p.Ile561Met) single nucleotide variant not provided [RCV002825495] Chr1:186965512 [GRCh38]
Chr1:186934644 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.115+7G>A single nucleotide variant not provided [RCV002913915] Chr1:186870523 [GRCh38]
Chr1:186839655 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.115+13T>A single nucleotide variant not provided [RCV002571679] Chr1:186870529 [GRCh38]
Chr1:186839661 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1295A>G (p.Asn432Ser) single nucleotide variant Inborn genetic diseases [RCV003167754]|not provided [RCV002756981] Chr1:186950687 [GRCh38]
Chr1:186919819 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1531G>A (p.Ala511Thr) single nucleotide variant Inborn genetic diseases [RCV002704832] Chr1:186956296 [GRCh38]
Chr1:186925428 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1034-13A>T single nucleotide variant not provided [RCV002820933] Chr1:186946624 [GRCh38]
Chr1:186915756 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1129G>A (p.Val377Ile) single nucleotide variant not provided [RCV002622379] Chr1:186946732 [GRCh38]
Chr1:186915864 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.417-17T>A single nucleotide variant not provided [RCV002847769] Chr1:186911231 [GRCh38]
Chr1:186880363 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1188C>A (p.Ala396=) single nucleotide variant PLA2G4A-related condition [RCV003936500]|not provided [RCV002999329] Chr1:186946885 [GRCh38]
Chr1:186916017 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.626T>C (p.Met209Thr) single nucleotide variant not provided [RCV002999043] Chr1:186932830 [GRCh38]
Chr1:186901962 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.264+8A>G single nucleotide variant not provided [RCV002913980] Chr1:186893167 [GRCh38]
Chr1:186862299 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1952G>A (p.Arg651Lys) single nucleotide variant not provided [RCV003038580] Chr1:186977780 [GRCh38]
Chr1:186946912 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1840C>T (p.Arg614Trp) single nucleotide variant not provided [RCV002626229] Chr1:186977668 [GRCh38]
Chr1:186946800 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.33+20T>C single nucleotide variant not provided [RCV002576462] Chr1:186854407 [GRCh38]
Chr1:186823539 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.2119-14G>A single nucleotide variant not provided [RCV002667641] Chr1:186988363 [GRCh38]
Chr1:186957495 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.559-17C>T single nucleotide variant not provided [RCV002800646] Chr1:186932746 [GRCh38]
Chr1:186901878 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.303T>C (p.Thr101=) single nucleotide variant not provided [RCV003057841] Chr1:186894136 [GRCh38]
Chr1:186863268 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.720C>T (p.His240=) single nucleotide variant not provided [RCV002594666] Chr1:186939032 [GRCh38]
Chr1:186908164 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.293T>C (p.Met98Thr) single nucleotide variant not provided [RCV002828820] Chr1:186894126 [GRCh38]
Chr1:186863258 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1336+3G>A single nucleotide variant not provided [RCV002852035] Chr1:186950731 [GRCh38]
Chr1:186919863 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.764del (p.Leu255fs) deletion not provided [RCV002594954] Chr1:186939076 [GRCh38]
Chr1:186908208 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1336+11C>T single nucleotide variant not provided [RCV002700203] Chr1:186950739 [GRCh38]
Chr1:186919871 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.2128G>A (p.Glu710Lys) single nucleotide variant not provided [RCV002958429] Chr1:186988386 [GRCh38]
Chr1:186957518 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1264+11G>T single nucleotide variant not provided [RCV002594497] Chr1:186946972 [GRCh38]
Chr1:186916104 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1437C>G (p.Phe479Leu) single nucleotide variant not provided [RCV002941934] Chr1:186956202 [GRCh38]
Chr1:186925334 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.390G>C (p.Met130Ile) single nucleotide variant Inborn genetic diseases [RCV002877833] Chr1:186906976 [GRCh38]
Chr1:186876108 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.419C>T (p.Ser140Leu) single nucleotide variant Inborn genetic diseases [RCV002919990] Chr1:186911250 [GRCh38]
Chr1:186880382 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1337-17C>T single nucleotide variant not provided [RCV002601251] Chr1:186956085 [GRCh38]
Chr1:186925217 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1509A>G (p.Pro503=) single nucleotide variant not provided [RCV002937593] Chr1:186956274 [GRCh38]
Chr1:186925406 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.115+17dup duplication not provided [RCV002597606] Chr1:186870526..186870527 [GRCh38]
Chr1:186839658..186839659 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1585G>A (p.Asp529Asn) single nucleotide variant Inborn genetic diseases [RCV002831401] Chr1:186965414 [GRCh38]
Chr1:186934546 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1336+13G>C single nucleotide variant not provided [RCV002576861] Chr1:186950741 [GRCh38]
Chr1:186919873 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1989A>G (p.Lys663=) single nucleotide variant not provided [RCV002938331] Chr1:186979343 [GRCh38]
Chr1:186948475 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.2241C>T (p.Pro747=) single nucleotide variant not provided [RCV002603762] Chr1:186988499 [GRCh38]
Chr1:186957631 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.77G>A (p.Arg26His) single nucleotide variant not provided [RCV002603450] Chr1:186870478 [GRCh38]
Chr1:186839610 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1799A>G (p.Asn600Ser) single nucleotide variant Inborn genetic diseases [RCV002724381] Chr1:186977627 [GRCh38]
Chr1:186946759 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.506T>A (p.Met169Lys) single nucleotide variant Inborn genetic diseases [RCV002944672] Chr1:186911337 [GRCh38]
Chr1:186880469 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.687C>G (p.Gly229=) single nucleotide variant not provided [RCV002609290] Chr1:186932891 [GRCh38]
Chr1:186902023 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.115+4_115+5dup duplication not provided [RCV002943159] Chr1:186870519..186870520 [GRCh38]
Chr1:186839651..186839652 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.115+16T>A single nucleotide variant not provided [RCV002613092] Chr1:186870532 [GRCh38]
Chr1:186839664 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1291A>C (p.Ser431Arg) single nucleotide variant Inborn genetic diseases [RCV003376989] Chr1:186950683 [GRCh38]
Chr1:186919815 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1496A>G (p.Asn499Ser) single nucleotide variant Inborn genetic diseases [RCV003348479] Chr1:186956261 [GRCh38]
Chr1:186925393 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1497T>C (p.Asn499=) single nucleotide variant not provided [RCV003738708] Chr1:186956262 [GRCh38]
Chr1:186925394 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.759A>G (p.Glu253=) single nucleotide variant not provided [RCV003547239] Chr1:186939071 [GRCh38]
Chr1:186908203 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1579+20T>C single nucleotide variant not provided [RCV003828363] Chr1:186956364 [GRCh38]
Chr1:186925496 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1251G>A (p.Met417Ile) single nucleotide variant not provided [RCV003849065] Chr1:186946948 [GRCh38]
Chr1:186916080 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1258G>C (p.Glu420Gln) single nucleotide variant not provided [RCV003878578] Chr1:186946955 [GRCh38]
Chr1:186916087 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1383del (p.Ala462fs) deletion not provided [RCV003572173] Chr1:186956147 [GRCh38]
Chr1:186925279 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1264+17C>T single nucleotide variant not provided [RCV003824868] Chr1:186946978 [GRCh38]
Chr1:186916110 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1830T>C (p.Tyr610=) single nucleotide variant not provided [RCV003826288] Chr1:186977658 [GRCh38]
Chr1:186946790 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1336+12G>A single nucleotide variant not provided [RCV003713451] Chr1:186950740 [GRCh38]
Chr1:186919872 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1500A>G (p.Thr500=) single nucleotide variant not provided [RCV003831351] Chr1:186956265 [GRCh38]
Chr1:186925397 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1671G>C (p.Pro557=) single nucleotide variant not provided [RCV003695458] Chr1:186965500 [GRCh38]
Chr1:186934632 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.116-7T>C single nucleotide variant not provided [RCV003715196] Chr1:186893004 [GRCh38]
Chr1:186862136 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1416G>A (p.Leu472=) single nucleotide variant not provided [RCV003547826] Chr1:186956181 [GRCh38]
Chr1:186925313 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1261T>C (p.Leu421=) single nucleotide variant not provided [RCV003662105] Chr1:186946958 [GRCh38]
Chr1:186916090 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1128A>T (p.Thr376=) single nucleotide variant not provided [RCV003881066] Chr1:186946731 [GRCh38]
Chr1:186915863 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.696-20G>A single nucleotide variant not provided [RCV003881314] Chr1:186938988 [GRCh38]
Chr1:186908120 [GRCh37]
Chr1:1q31.1		 benign
NM_024420.3(PLA2G4A):c.1033+15T>C single nucleotide variant not provided [RCV003825005] Chr1:186940109 [GRCh38]
Chr1:186909241 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.15T>C (p.Asp5=) single nucleotide variant not provided [RCV003547973] Chr1:186854369 [GRCh38]
Chr1:186823501 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.165C>G (p.Asp55Glu) single nucleotide variant not provided [RCV003665041] Chr1:186893060 [GRCh38]
Chr1:186862192 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.948G>A (p.Lys316=) single nucleotide variant not provided [RCV003852486] Chr1:186940009 [GRCh38]
Chr1:186909141 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1281G>A (p.Lys427=) single nucleotide variant not provided [RCV003855629] Chr1:186950673 [GRCh38]
Chr1:186919805 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1580-11_1580-10del deletion not provided [RCV003855689] Chr1:186965397..186965398 [GRCh38]
Chr1:186934529..186934530 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1224T>C (p.Ser408=) single nucleotide variant not provided [RCV003725371] Chr1:186946921 [GRCh38]
Chr1:186916053 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1148A>G (p.Glu383Gly) single nucleotide variant not provided [RCV003673949] Chr1:186946751 [GRCh38]
Chr1:186915883 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.235T>C (p.Leu79=) single nucleotide variant not provided [RCV003672120] Chr1:186893130 [GRCh38]
Chr1:186862262 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.906A>C (p.Thr302=) single nucleotide variant not provided [RCV003558965] Chr1:186939218 [GRCh38]
Chr1:186908350 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1143T>C (p.Tyr381=) single nucleotide variant not provided [RCV003668421] Chr1:186946746 [GRCh38]
Chr1:186915878 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1961-6A>G single nucleotide variant not provided [RCV003717033] Chr1:186979309 [GRCh38]
Chr1:186948441 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.648A>T (p.Gly216=) single nucleotide variant not provided [RCV003814682] Chr1:186932852 [GRCh38]
Chr1:186901984 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1891G>A (p.Glu631Lys) single nucleotide variant not provided [RCV003666373] Chr1:186977719 [GRCh38]
Chr1:186946851 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.1336+16A>C single nucleotide variant not provided [RCV003667333] Chr1:186950744 [GRCh38]
Chr1:186919876 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.559-12G>A single nucleotide variant not provided [RCV003857860] Chr1:186932751 [GRCh38]
Chr1:186901883 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.115+16T>C single nucleotide variant not provided [RCV003677443] Chr1:186870532 [GRCh38]
Chr1:186839664 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1034-19G>A single nucleotide variant not provided [RCV003846192] Chr1:186946618 [GRCh38]
Chr1:186915750 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.669C>T (p.Tyr223=) single nucleotide variant not provided [RCV003729301] Chr1:186932873 [GRCh38]
Chr1:186902005 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1230A>C (p.Ser410=) single nucleotide variant not provided [RCV003719074] Chr1:186946927 [GRCh38]
Chr1:186916059 [GRCh37]
Chr1:1q31.1		 likely benign
GRCh37/hg19 1q24.2-31.1(chr1:167994071-187711459)x1 copy number loss not specified [RCV003987250] Chr1:167994071..187711459 [GRCh37]
Chr1:1q24.2-31.1		 pathogenic
NM_024420.3(PLA2G4A):c.1337-8T>G single nucleotide variant not provided [RCV003870980] Chr1:186956094 [GRCh38]
Chr1:186925226 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.452G>A (p.Cys151Tyr) single nucleotide variant not provided [RCV003709993] Chr1:186911283 [GRCh38]
Chr1:186880415 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.624G>A (p.Val208=) single nucleotide variant not provided [RCV003704118] Chr1:186932828 [GRCh38]
Chr1:186901960 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.100G>A (p.Ala34Thr) single nucleotide variant not provided [RCV003720486] Chr1:186870501 [GRCh38]
Chr1:186839633 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.919-14T>A single nucleotide variant not provided [RCV003677613] Chr1:186939966 [GRCh38]
Chr1:186909098 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1310_1312del (p.Ser437_Asp438delinsAsn) deletion not provided [RCV003719636] Chr1:186950702..186950704 [GRCh38]
Chr1:186919834..186919836 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.309G>C (p.Gly103=) single nucleotide variant not provided [RCV003866432] Chr1:186894142 [GRCh38]
Chr1:186863274 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1218C>T (p.Gly406=) single nucleotide variant not provided [RCV003719687] Chr1:186946915 [GRCh38]
Chr1:186916047 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1304C>T (p.Ser435Leu) single nucleotide variant not provided [RCV003734213] Chr1:186950696 [GRCh38]
Chr1:186919828 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_024420.3(PLA2G4A):c.651T>C (p.Ile217=) single nucleotide variant not provided [RCV003555555] Chr1:186932855 [GRCh38]
Chr1:186901987 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.645A>G (p.Ser215=) single nucleotide variant not provided [RCV003552621] Chr1:186932849 [GRCh38]
Chr1:186901981 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.1503T>C (p.Ser501=) single nucleotide variant not provided [RCV003861442] Chr1:186956268 [GRCh38]
Chr1:186925400 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.63G>A (p.Thr21=) single nucleotide variant PLA2G4A-related condition [RCV003962034] Chr1:186870464 [GRCh38]
Chr1:186839596 [GRCh37]
Chr1:1q31.1		 likely benign
NM_024420.3(PLA2G4A):c.888G>A (p.Gly296=) single nucleotide variant PLA2G4A-related condition [RCV003923917] Chr1:186939200 [GRCh38]
Chr1:186908332 [GRCh37]
Chr1:1q31.1		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:193
Interacting mature miRNAs:199
Transcripts:ENST00000367466, ENST00000442353, ENST00000466600
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
AL034257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,842,043 - 186,842,217UniSTSGRCh37
Build 361185,108,666 - 185,108,840RGDNCBI36
Celera1159,952,352 - 159,952,526RGD
Cytogenetic Map1q25UniSTS
HuRef1158,076,235 - 158,076,409UniSTS
RH104487  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,796,567 - 186,796,762UniSTSGRCh37
Build 361185,063,190 - 185,063,385RGDNCBI36
Celera1159,906,900 - 159,907,095RGD
Cytogenetic Map1q25UniSTS
HuRef1158,031,019 - 158,031,214UniSTS
GeneMap99-GB4 RH Map1639.22UniSTS
GDB:321239  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,796,726 - 186,796,885UniSTSGRCh37
Build 361185,063,349 - 185,063,508RGDNCBI36
Celera1159,907,059 - 159,907,218RGD
Cytogenetic Map1q25UniSTS
HuRef1158,031,178 - 158,031,328UniSTS
G67877  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,915,812 - 186,916,059UniSTSGRCh37
Build 361185,182,435 - 185,182,682RGDNCBI36
Celera1160,026,194 - 160,026,441RGD
Cytogenetic Map1q25UniSTS
HuRef1158,150,032 - 158,150,279UniSTS
D1S3128  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,851,267 - 186,851,494UniSTSGRCh37
Build 361185,117,890 - 185,118,117RGDNCBI36
Celera1159,961,650 - 159,961,877RGD
Cytogenetic Map1q25UniSTS
HuRef1158,085,533 - 158,085,760UniSTS
D1S3460  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,900,471 - 186,900,721UniSTSGRCh37
Build 361185,167,094 - 185,167,344RGDNCBI36
Celera1160,010,853 - 160,011,103RGD
Cytogenetic Map1q25UniSTS
HuRef1158,134,683 - 158,134,933UniSTS
Marshfield Genetic Map1201.58UniSTS
deCODE Assembly Map1187.23UniSTS
RH17731  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,957,747 - 186,958,011UniSTSGRCh37
Build 361185,224,370 - 185,224,634RGDNCBI36
Celera1160,068,156 - 160,068,420RGD
Cytogenetic Map1q25UniSTS
HuRef1158,191,986 - 158,192,250UniSTS
GeneMap99-GB4 RH Map1639.22UniSTS
SHGC-35515  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,957,727 - 186,957,933UniSTSGRCh37
Build 361185,224,350 - 185,224,556RGDNCBI36
Celera1160,068,136 - 160,068,342RGD
Cytogenetic Map1q25UniSTS
HuRef1158,191,966 - 158,192,172UniSTS
Marshfield Genetic Map12136.82UniSTS
Stanford-G3 RH Map17257.0UniSTS
GeneMap99-GB4 RH Map1640.63UniSTS
GeneMap99-GB4 RH Map1639.22UniSTS
Whitehead-RH Map1797.5UniSTS
NCBI RH Map11573.4UniSTS
GeneMap99-G3 RH Map17213.0UniSTS
D13AT1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,797,781 - 186,797,941UniSTSGRCh37
Build 361185,064,404 - 185,064,564RGDNCBI36
Celera1159,908,115 - 159,908,275RGD
HuRef1158,032,225 - 158,032,385UniSTS
GDB:582583  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q25UniSTS
PLA2G4A  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,908,183 - 186,909,189UniSTSGRCh37
Celera1160,018,568 - 160,019,571UniSTS
HuRef1158,142,406 - 158,143,409UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 849 413 206 73 439 14 1271 86 155 137 658 463 68 459 666 1
Low 1566 2467 1361 405 1313 305 2579 1521 3323 262 779 1071 106 1 744 1615 4 2
Below cutoff 14 104 153 143 98 143 504 584 241 16 17 41 1 504

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001311193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005245267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047422599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK290336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY552098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX118890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA451491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ399336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC888000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M72393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z33877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000367466   ⟹   ENSP00000356436
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,828,949 - 186,988,981 (+)Ensembl
RefSeq Acc Id: ENST00000466600
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,854,286 - 186,939,230 (+)Ensembl
RefSeq Acc Id: NM_001311193   ⟹   NP_001298122
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,828,949 - 186,988,981 (+)NCBI
CHM1_11188,219,298 - 188,379,410 (+)NCBI
T2T-CHM13v2.01186,183,318 - 186,343,553 (+)NCBI
Sequence:
RefSeq Acc Id: NM_024420   ⟹   NP_077734
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,828,949 - 186,988,981 (+)NCBI
GRCh371186,798,032 - 186,958,113 (+)ENTREZGENE
Build 361185,064,655 - 185,224,736 (+)NCBI Archive
HuRef1158,032,476 - 158,192,352 (+)ENTREZGENE
CHM1_11188,219,298 - 188,379,410 (+)NCBI
T2T-CHM13v2.01186,183,318 - 186,343,553 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005245267   ⟹   XP_005245324
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,870,597 - 186,988,981 (+)NCBI
GRCh371186,798,032 - 186,958,113 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509642   ⟹   XP_011507944
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,828,949 - 186,988,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047422599   ⟹   XP_047278555
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,828,949 - 186,965,593 (+)NCBI
RefSeq Acc Id: XM_054337080   ⟹   XP_054193055
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01186,225,052 - 186,343,553 (+)NCBI
RefSeq Acc Id: XM_054337081   ⟹   XP_054193056
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01186,183,301 - 186,343,553 (+)NCBI
RefSeq Acc Id: XM_054337082   ⟹   XP_054193057
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01186,183,318 - 186,320,151 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_077734   ⟸   NM_024420
- Peptide Label: isoform 1
- UniProtKB: P47712 (UniProtKB/Swiss-Prot),   B1AKG4 (UniProtKB/Swiss-Prot),   Q29R80 (UniProtKB/Swiss-Prot),   A8K2S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005245324   ⟸   XM_005245267
- Peptide Label: isoform X1
- UniProtKB: A8K2S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011507944   ⟸   XM_011509642
- Peptide Label: isoform X2
- UniProtKB: B1AKG4 (UniProtKB/Swiss-Prot),   Q29R80 (UniProtKB/Swiss-Prot),   P47712 (UniProtKB/Swiss-Prot),   A8K2S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001298122   ⟸   NM_001311193
- Peptide Label: isoform 2
- UniProtKB: B4DZI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000356436   ⟸   ENST00000367466
RefSeq Acc Id: XP_047278555   ⟸   XM_047422599
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054193056   ⟸   XM_054337081
- Peptide Label: isoform X2
- UniProtKB: A8K2S1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054193057   ⟸   XM_054337082
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054193055   ⟸   XM_054337080
- Peptide Label: isoform X1
- UniProtKB: A8K2S1 (UniProtKB/TrEMBL)
Protein Domains
C2   PLA2c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47712-F1-model_v2 AlphaFold P47712 1-749 view protein structure

Promoters
RGD ID:6786252
Promoter ID:HG_KWN:6590
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:NM_024420
Position:
Human AssemblyChrPosition (strand)Source
Build 361185,064,574 - 185,065,074 (+)MPROMDB
RGD ID:6858412
Promoter ID:EPDNEW_H2371
Type:initiation region
Name:PLA2G4A_1
Description:phospholipase A2 group IVA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,828,990 - 186,829,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9035 AgrOrtholog
COSMIC PLA2G4A COSMIC
Ensembl Genes ENSG00000116711 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367466 ENTREZGENE
  ENST00000367466.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytosolic phospholipase A2 catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000116711 GTEx
HGNC ID HGNC:9035 ENTREZGENE
Human Proteome Map PLA2G4A Human Proteome Map
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_cPLA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LysoPLipase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5321 UniProtKB/Swiss-Prot
NCBI Gene 5321 ENTREZGENE
OMIM 600522 OMIM
PANTHER CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  CYTOSOLIC PHOSPHOLIPASE A2 UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLA2_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA271 PharmGKB, RGD
PROSITE PLA2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLAc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K2S1 ENTREZGENE, UniProtKB/TrEMBL
  B1AKG4 ENTREZGENE
  B4DZI4 ENTREZGENE, UniProtKB/TrEMBL
  P47712 ENTREZGENE, UniProtKB/Swiss-Prot
  Q14064_HUMAN UniProtKB/TrEMBL
  Q29R80 ENTREZGENE
  W0FXB0_HUMAN UniProtKB/TrEMBL
UniProt Secondary B1AKG4 UniProtKB/Swiss-Prot
  Q29R80 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLA2G4A  phospholipase A2 group IVA  PLA2G4A  phospholipase A2, group IVA (cytosolic, calcium-dependent)  Symbol and/or name change 5135510 APPROVED